A5022423154- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Advancements in Transdermal Drug Delivery
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Retinal and Optic Conditions
- Connexins and lens biology
- Multiple Myeloma Research and Treatments
- Biomedical Research and Pathophysiology
- Advanced Drug Delivery Systems
- Allergic Rhinitis and Sensitization
- Neonatal Health and Biochemistry
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Nanoparticles: synthesis and applications
- Circadian rhythm and melatonin
- Enzyme Structure and Function
- Antioxidant Activity and Oxidative Stress
- Mitochondrial Function and Pathology
- RNA regulation and disease
- Vitamin C and Antioxidants Research
Semmelweis University
2019-2025
Abstract Ocular surface inflammation due to allergy and blepharitis can lead corneal complications visual impairment. The aim of this study is evaluate the efficacy a cyclosporin 0.1% topical treatment achieving steroid-sparing. Eighty pediatric patients with moderate severe vernal blepharitis-related keratoconjunctivitis were included. Symptoms (photosensitivity, itching, discharge, tearing), signs (corneal fluorescein staining, papillary hypertrophy) patients’ subjective assessment...
Purpose During life up to 70% of aniridia subjects develop aniridia-associated keratopathy (AAK). AAK is characterized by limbal stem cell insufficiency, impaired corneal epithelial differentiation and abnormal adhesion, which leads centripetal spreading vascularization, conjunctivalization, thickening the cornea. Our aim was examine subbasal nerve plexus central stromal microstructure in with congenital aniridia, using vivo confocal laser scanning microscopy CLSM.
Abstract Ascorbic acid (AA) has a pivotal role in corneal wound healing via stimulating the biosynthesis of highly organized extracellular matrix components, but its rapid degradation and low permeability limits therapeutic effects. In this paper, we present pharmacokinetic properties liposomal-based formulation AA terms permeation. Chemical stability, shelf-life, drug release rate lyophilized liposome (AA-LLipo) was determined comparison to free-form solution using high-performance liquid...
The purpose of our study was to analyze abnormal neural regeneration activity in the cornea through means confocal microscopy rheumatoid arthritis patients with concomitant dry eye disease. We examined 40 variable severity and 44 volunteer age- gender-matched healthy control subjects. found that all parameters were significantly lower (p < 0.05) as opposed samples: namely, number fibers, total length nerves, branch points on main fibers nerve-fiber area. further variables, such age, sex...
Our objective in this study was to analyze the aberrant neural regeneration activity cornea by means of vivo confocal microscopy systemic lupus erythematosus patients with concurrent dry eye disease. We examined 29 and age-matched healthy control subjects. Corneal nerve fiber density (CNFD, number fibers/mm2) peripheral Langerhans cell morphology were lower (p < 0.05) compared group. Interestingly, corneal branch density, length, total area showed a negative correlation disease duration. A...
This study aimed at analyzing the corneal neural regeneration in ankylosing spondylitis patients using vivo confocal microscopy correlation with Langerhans cell density, morphology, and dry eye parameters. Approximately 24 subjects 35 age- gender-matched control were enrolled. Data analysis showed that all nerve-fiber descriptives lower group, implicating disrupted regeneration. Peripheral density a negative nerve fiber descriptions. A between tear film break-up time total branch was...
Abstract Based on wavefront sensor images an objective and quantitative method is presented for characterising cataract. By separating direct scattered light in the focal plane of microlenses, new procedure able to make two-dimensional maps spatial variation scattering properties crystalline lens, also provides a single figure descriptive whole eye. The developed evaluation algorithm successfully quantifies cataract, especially that nuclear type. To demonstrate its operation, custom-built...
This study investigated the morphological characteristics of corneal microstructure in quiescent phase vernal keratoconjunctivitis (VKC).Twenty patients with VKC and 25 healthy subjects were included. In vivo confocal microscopy (IVCM) central cornea was performed. Cellular density each layer morphology subbasal nerve plexus (SBNP) analysed. Langerhans cell (LCD), (LCM), field area (LCF) also examined.No differences found either densities nor SBNP (p > 0.05). LCD, LCM LCF significantly...
Presence of corneal cystine crystals is the main ocular manifestation cystinosis, although controversial findings concerning layer with highest density have been reported. The aim this study was analysis characteristics crystal arrangement in different layers and assessment morphological changes age.A cross sectional carried out three children adults who had nephropathic cystinosis depositions. All patients underwent a comprehensive ophthalmological examination including best corrected...
Abstract Background Our aim was to determine associations of pachymetry, keratometry, and their changes with haze formation corneal flattening after collagen cross-linking, analyse the relationship between postoperative visual outcome. Methods Retrospective analysis performed on 47 eyes patients keratoconus using Pentacam HR Scheimpflug camera before 1, 3, 6 12 months cross-linking. Corneal backscattered light values in grey scale unit were recorded anterior, center posterior layers four...
Bevezetés: A congenitalis aniridia ritka betegség, melynek fő jellemzője a szivárványhártya teljes vagy részleges hiánya, azonban szem összes struktúrájában jelen lehetnek elváltozások. Célkitűzés: Társuló szembetegségek előfordulásának meghatározása aniridiában, egy magyarországi centrum betegeinek vizsgálatával. Betegek és módszerek: Munkánkba Semmelweis Egyetem Szemészeti Klinikáján 2005. október 2022. május között diagnózisával vizsgált betegeket válogattunk be. betegek...
Abstract: The prevalence of allergic diseases has been increasing recently. Allergy various symptoms. Allergic eye (seasonal and perennial conjunctivitis, vernal keratoconjunctivitis, atopic giant papillary contact blepharoconjunctivitis) are common in patients. Treatment options for conjunctivitis include local systemic antihistamines, mast cell stabilizers, dual-action agents, vasoconstrictors corticosteroids. seems easy, but inappropriate therapy – extreme cases can lead to vision loss....
Corneal imaging may support an early diagnosis of monoclonal gammopathy. The goal our study was to analyze corneal stromal properties using Pentacam and in vivo confocal cornea microscopy (IVCM) subjects with In cross-sectional study, patients gammopathy (130 eyes 65 (40.0% males; age 67.65 ± 9.74 years)) randomly selected individuals the same group, without hematological disease (100 50 control 60.67 15.06 were included. Using (Pentacam HR; Oculus GmbH, Wetzlar, Germany), light scattering...
Purpose There is abundant evidence on the benefits of physical activity cardiovascular health. However, there are only few data acute effects exercise retina and choroid. Our aim was in vivo examination chorioretinal alterations following short intense by spectral domain optical coherence tomography (SD-OCT). Methods Twenty-one eyes 21 healthy, young subjects (mean age 22.5 ± 4.1 years, 15 males 6 females) were recruited. Macular scanning with a SD-OCT performed before vita maxima-type...
To examine the ocular signs of monoclonal gammopathy and to evaluate comorbidities in subjects with gammopathy. Patients Methods. We analyzed patients from two large referral hematology centers Budapest, diagnosed and/or treated between 1997 2020. As a control group, randomly selected individuals same age without hematological disease, have been included. There were 160 eyes 80 (38.75% males; 67.61 ± 10.48 (range: 38-85) years) 86 43 (32.56% 62.44 11.89 (range 37-86) years). The diagnosis...
Abstract There is only limited information available on the effects of physical exercise posterior pole. Retinal circulation autoregulated similarly to brain vasculature in order provide constant flow and thus nutrition inner retinal structures while choroid mostly controlled by sympathetic nervous system. The data show that may indeed have a positive effect retina visual function. assessment structure could serve as marker sports medicine, whereas activity exert protective against diseases...
In PAX6 syndrome, it is still not clear, whether prenatally, parallel to the iris tissue developmental anomaly, there neural ectodermal, crest, or mesodermal cell deposition at corneal endothelium, affecting endothelial structure and function. addition, because of postnatal inflammation commonly appearing secondary glaucoma, progressive changes are expected. Our purpose was study endothelium in subjects with aniridia, using vivo confocal laser scanning microscopy.
Purpose : Congenital aniridia is a rare disease, with global prevalence of 1 in 40 000 to 100 000. During life up 70% sufferers develop aniridia‐associated keratopathy (AAK) limbal stem cell insufficiency, impaired corneal epithelial differentiation, abnormal adhesion and wound healing. AAK characterized by centripetal spreading vascularization, conjunctivalization, thickening the cornea. We examined sub‐basal nerve plexus central stromal microstructure subjects congenital aniridia, using...
Cystinosis is a low-prevalence lysosomal storage disease. The pathomechanism involves abnormal functioning of the cystinosine cystine transporter (CTNS), causing intraliposomal accumulation amino acid cysteine disulfide, which crystallizes and deposits in several parts body. most common ophthalmic complication cystinosis deposition "gold dust" crystals on cornea, already occurs infancy leads to severe photosensitivity dry eyes as it gradually progresses with age. In specific treatment...
A vernalis keratoconjunctivitis a gyermekkori allergiás kötőhártya-gyulladások egy súlyos formája, amely többségében serdülőkort követően spontán megszűnik. Néhány esetben az alkalmazott terápia mellékhatásaként vagy gyulladásos eltérések következményeként maradandó látásromláshoz vezethet. megbetegedés gyakran szövődik keratoconussal, amelyet szemviszketés és következményes gyakori szemdörzsölés szövődményeként tartanak számon. Esetismertetésünkben szokatlanul elhúzódó lefolyású,...
Bevezetés: A congenitalis aniridia ritka panocularis betegség, amelyben a szem csaknem minden struktúrája érintett, és betegek többségének jelentősen csökkent látóélessége. szemészeti jelei lehetnek az aniridiához társult keratopathia, másodlagos zöld hályog, szürke macula- opticus-hypoplasia, nystagmus. Noha keratopathia kifejezés régóta elterjedt irodalomban, sokféle stádiumbeosztási javaslata került már leírásra. Célkitűzés: Az egyes stádiumainak vizsgálata irodalomban elérhető...