A5048182002- Hydrogels: synthesis, properties, applications
- Advanced Drug Delivery Systems
- Advanced Polymer Synthesis and Characterization
- Ocular Surface and Contact Lens
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Electrochemical sensors and biosensors
- Porphyrin and Phthalocyanine Chemistry
- Drug Solubulity and Delivery Systems
- Surfactants and Colloidal Systems
- Enzyme Catalysis and Immobilization
- Graphene and Nanomaterials Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Graphene research and applications
- Supramolecular Self-Assembly in Materials
- Conducting polymers and applications
- Electrospun Nanofibers in Biomedical Applications
- Injection Molding Process and Properties
- Advanced Sensor and Energy Harvesting Materials
- Carbohydrate Chemistry and Synthesis
- Advancements in Transdermal Drug Delivery
- Synthesis and properties of polymers
- Rheology and Fluid Dynamics Studies
- Electronic Packaging and Soldering Technologies
Budapest University of Technology and Economics
2015-2024
Institute of Materials and Environmental Chemistry
2013-2018
Hungarian Academy of Sciences
2013
Gedeon Richter (Hungary)
2009
A substantial effort has been made in the last few decades to develop responsive materials that produce a selective answer well-defined environmental stimuli. In our present review, we focus on chemistry of thiol–disulphide equilibrium and its incorporation into polymer-based soft materials. Because several papers extensive reviews have focused reduction-sensitive drug delivery gene transfer, would like especially emphasise importance disulphide formation exploitation reversible...
Synthesis and characterization of a pH- redox-sensitive hydrogel poly(aspartic acid) are reported. Reversible gelation dissolution achieved both in dimethylformamide aqueous medium via thiol-disulphide interconversion the side chain polymers. Structural changes confirmed by Raman microscopy rheological measurements. Injectable solutions thiolated can be converted into mechanically stable gels oxidation, which useful for drug encapsulation targeted delivery. Reduction-facilitated release an...
Synthetic polyaspartamides with various functional side groups including primary, secondary, tertiary amine or carboxyl were designed to explore the effect of chemical composition on polymer-mucin interactions. Since molecular weight polymers and degree modification identical for each derivative, role could be evaluated. Chitosan was used as a control sample due its strong interaction mucin primarily through electrostatic forces. Mucoadhesive interactions aqueous dispersion commercially...
The optical properties of polypropylene (PP) were modified by nine different sorbitol type clarifiers available commercially or synthesized in the study. solubility PP was estimated thermodynamic model calculations. results showed that these additives is small, a few 1000 ppm at most. Solubility determined chemical structure sorbitol, and heat fusion latter changes least one order magnitude. can be reasonably Flory–Huggins lattice theory. morphology most sorbitols transforms temperature much...
Although achieving good activated sludge settleability is a key requirement for meeting effluent quality criteria, wastewater treatment plants often face undesired floc structure changes. Filamentous bulking has widely been studied, however, viscous formation much less investigated so far. Our main goal was to find relationship between and related rheological properties, moreover, estimate pressure loss in pipe networks through hydrodynamic modelling of the non-Newtonian flows case well...
Mucoadhesion testing at macroscopic scale needs a robust, convenient in vitro method as ex vivo methods suffer from poor reproducibility and ethical problems. Here we synthesized mucin-free poly(vinyl alcohol) (PVA) mucin-containing PVA hydrogel substrates (Muc/PVA) to measure adhesion of polymer tablets. Freezing-thawing was used for gelation avoid chemical cross-linking preserve the functionality mucin. The first generation mucoadhesive polymers, poly(acrylic acid) (PAA)...
Abstract The predictive performance of five different p K a prediction tools (ACDpKa, Epik, Marvin pKa, Pallas and VCCpKa) was investigated on the 248‐membered Gold Standard dataset. We found VCC as most predictive, high throughput predictor. However since calculates for acidic or basic group only we concluded that ACD are in fact method choice medicinal chemistry applications. Analyzing common outliers identified guanidines, enolic hydroxyl groups weak NHs problematic moieties from point...
Nanogels loaded with fluorescent dextran as a model drug are synthesized by the oxidation induced cross‐linking of water soluble redox responsive thiolated poly(amino acid) in miniemulsion without introduction any cross‐linker molecule. Two types high energy methods, namely, ultrasonication and pressure homogenization (HPH), compared. Dynamic light scattering transmission electron microscopy measurements confirm that spherical nanogels 100–150 nm diameter range prepared successfully HPH...
Thiolated poly(aspartic acid) is known as a good mucoadhesive polymer in aqueous ophthalmic formulations. In this paper, cyclodextrin-modified thiolated was synthesized for the incorporation of prednisolone, lipophilic drug, an situ gellable solution. This combines advantages cyclodextrins and polymers. The formation cyclodextrin-drug complex gels analyzed by X-ray powder diffraction. ocular applicability characterized means physicochemical, rheological drug diffusion tests. It established...
A redox- and pH-responsive poly(aspartic acid) (PASP) hydrogel is synthesised by cross-linking cysteamine modified polysuccinimide (PSI) with non-cleavable cross-linker 1,4-diaminobutane followed the hydrolysis of resultant PSI gel to a PASP hydrogel. The showed remarkable change in its degree swelling as function external pH because polyelectrolyte character network. In addition pH-dependent swelling, thiolation polymer rendered redox responsive behaviour acid). could be tuned reversible...
A synthetic poly(amino acid), poly(aspartic acid) modified with thioethyl side groups, was studied as an in situ gelling and mucoadhesive dosage form. The chemical structure the controllable, large thiol content of polymer were confirmed using 1H NMR spectroscopy Ellman's assay. In gelation aqueous solutions induced by oxidation monitored oscillation rheometry. strength mucoadhesion towards excised mucosa characterised tensile tests ex vivo experiments. Release kinetics ophthalmic antibiotic...
A convenient procedure was developed for the manufacturing of partially bio-ionic liquids (ILs) from renewable γ-valerolactone (GVL) and cheap readily available tetraalkylphosphonium bromides with excellent (>99%) yields. The novel ionic were characterized by their temperature dependent vapor pressure, density, viscosity, conductivity. We have proven that these ILs can be a useful medium copper-catalyzed Ullmann-type coupling reactions without use any ligand or additive, representing an...
Using long-lifetime fluorophores as protein labels, protein–nanoparticle interactions can be monitored through anisotropy change. Besides gaining thermodynamic and kinetic information on the binding process, competitive assays set up.
Owing to their versatile chemistry, polyaspartamides have recently attracted increased interest in various biomedical uses such as drug delivery systems and scaffolding materials. Solubility of these polymers organic solvents water at certain values pH can be fine-tuned by chemical composition, which was exploited here fabricate fast-dissolving electrospun matrices ethanol with no additives. Various side groups were tested control the solubility well morphology moisture uptake produced....