A5038967140- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Cytomegalovirus and herpesvirus research
- HIV Research and Treatment
- Immune Response and Inflammation
- Syphilis Diagnosis and Treatment
- Inflammasome and immune disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Yersinia bacterium, plague, ectoparasites research
- Occupational Health and Safety Research
- Dermatology and Skin Diseases
- Aging and Gerontology Research
- Pharmaceutical studies and practices
- Assisted Reproductive Technology and Twin Pregnancy
- Interprofessional Education and Collaboration
- Inflammatory Bowel Disease
- Cerebral Venous Sinus Thrombosis
- Cultural Competency in Health Care
- Medicine and Dermatology Studies History
- Palliative Care and End-of-Life Issues
- Ocular Oncology and Treatments
- Health and Wellbeing Research
Université de Sherbrooke
2025
Université de Montréal
1993-2023
Hôpital Maisonneuve-Rosemont
2009-2023
St. Mary's College
2018
Saint Mary's College of California
2009
National Eye Institute
1998-2003
National Cancer Institute
1998-1999
National Institutes of Health
1998-1999
Mount Sinai Hospital
1998
University Hospital Ayr
1998
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis.Phase 3, open-label, multicenter clinical trial extension (VISUAL III).Adults meeting treatment failure (TF) criteria who completed VISUAL I II (phase randomized, double-masked, placebo-controlled) without TF.Patients received 40 mg every other week. Interim follow-up data were described from III weeks 0 through 78.Disease quiescence, steroid-free active inflammatory...
To evaluate the safety and potential therapeutic activity of humanized anti-IL-2 receptor mAb (Daclizumab) therapy in treatment patients with severe, sight-threatening, intermediate posterior noninfectious uveitis, a nonrandomized, open-label, pilot study was performed. Patients uveitis were treated minimum 20 mg prednisone, cyclosporine, antimetabolites, or any combination these agents eligible. weaned off their systemic immunosuppressive according to standardized schedule, while ultimately...
PurposeTo evaluate long-term efficacy and safety of extended treatment with adalimumab in patients noninfectious intermediate, posterior, or panuveitis.DesignOpen-label, multicenter, phase 3 extension study (VISUAL III).ParticipantsAdults who had completed a randomized, placebo-controlled parent trial I II) without failure (inactive uveitis) discontinued the after meeting criteria (active uveitis).MethodsPatients received subcutaneous 40 mg every other week. Data were collected for ≤ 362...
Abstract Background Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by continuous colonic inflammation. In Canada, ~160,000 people suffer from its symptoms, such as diarrhea, blood in the stool and abdominal pain, which can highly impact their quality of life. For moderate to severe forms disease, molecular targeted therapies (MTT) are used control symptoms achieve remission. There large variability treatment response MTT. Indeed, ~20-50% MTT users don’t improve...
To evaluate the efficacy and safety of trabeculotomy in treatment pediatric uveitic glaucoma (UG).We retrospectively reviewed all cases that underwent for UG at our center between 2008 2014. Up to 2 trabeculotomies per eye were performed patients with medically controlled uveitis. Surgical success was defined as final intraocular pressure <22 mm Hg ≥6 after 1 or trabeculotomies, without medications. Kaplan-Meier survival analyses done.A total 33 28 eyes 22 patients. Diagnoses included...
To develop Canadian recommendations for the screening, monitoring, and treatment of uveitis associated with juvenile idiopathic arthritis (JIA). Recommendations were developed using Grading Assessment, Development, Evaluation (GRADE)-ADOLOPMENT approach. A working group 14 pediatric rheumatologists, 6 ophthalmologists, 2 methodologists, 3 caregiver/patient representatives reviewed recent American College Rheumatology (ACR)/Arthritis Foundation (AF) worked in pairs to evidence-to-decision...
Purpose: To assess efficacy of adalimumab versus placebo in patients with active or inactive noninfectious intermediate, posterior, panuveitis across different etiologies.Methods: VISUAL I (V–I) and II (V–II) clinical trials included adults uveitis, respectively, randomized to receive placebo. In a post hoc subgroup analysis, time treatment failure (TTF) starting at week 6 2 was analyzed using the Kaplan–Meier method. Hazard ratios (HR) for TTF 95% CI were calculated Cox proportional hazards...
Lens-associated uveitis (LAU), a severe inflammatory eye disease, is thought to be mediated by autoimmunity against lens crystallins. Previously described animal models for this disease are antibody-mediated, since no cellular response self crystallins could induced in experimental animals. Here, we describe new model LAU, which lymphocytes from knockout mice deficient alphaB-crystallin sensitized the deleted protein and induce ocular inflammation when adoptively transferred into wild type...
De façon générale, les enquêtes statistiques disponibles au Québec examinent conditions de travail indépendamment des caractéristiques travailleurs aux plans la santé et lésions professionnelles. L’Étude québécoise travail, d’emploi sécurité du (EQCOTESST) vise à corriger cette lacune. La première phase ce projet d’enquête quinquennale auprès 5 000 est prévue pour 2007. À l’aide ces données, il sera possible d’analyser liens existants entre un ensemble l’état risques d’accidents travail.