A5011266026- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Angiogenesis and VEGF in Cancer
- Retinal and Optic Conditions
- Multiple Sclerosis Research Studies
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Ocular Diseases and Behçet’s Syndrome
- Cerebral Venous Sinus Thrombosis
- Inflammatory mediators and NSAID effects
- Systemic Lupus Erythematosus Research
- Retinal and Macular Surgery
- Connexins and lens biology
- interferon and immune responses
- Traumatic Brain Injury and Neurovascular Disturbances
- Ocular Oncology and Treatments
- NF-κB Signaling Pathways
- Parvovirus B19 Infection Studies
- Ocular Infections and Treatments
- Histiocytic Disorders and Treatments
- Flavonoids in Medical Research
- Cholesterol and Lipid Metabolism
- Optical Coherence Tomography Applications
- Neurosurgical Procedures and Complications
Linköping University
2013-2023
Linköping University Hospital
2021
University of Padua
2005-2016
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
Corneal neovascularization is a sight-threatening condition caused by angiogenesis in the normally avascular cornea. Neovascularization of cornea often associated with an inflammatory response, thus targeting VEGF-A alone yields only limited efficacy. The NF-κB signaling pathway plays important roles inflammation and angiogenesis. Here, we study consequences inhibition activation through selective blockade IKK complex IκB kinase β (IKK2) using compound IMD0354, focusing on effects...
Background and Purpose The connexin 43 (Cx43) mimetic peptide Gap27 was designed to transiently block the function of this gap junction. This study undertaken investigate effect on corneal healing, inflammation neovascularization. Experimental Approach wound vascularization assessed in primary human epithelial cells (HCEC) vitro whole corneas ex vivo , an rat healing model. Key Results enhanced closure HCEC accelerated stratification epithelium but did not suppress release inflammatory...
Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and activated time-dependent manner. Effective resolution of inflammation associated angiogenesis requires knowledge these pathways their time dependence, which has, to date, remained largely unexplored. Here, using model endogenous inflammation-induced angiogenesis, we investigate...
Rosai-Dorfman disease (RDD) is a rare non-neoplastic histiocytic proliferative disorder characterized by painless lymphadenopathy. Extranodal lesions frequently occur in the head and neck regions. We report clinical histological features of extranodal RDD 43-year-old man with previously unreported combination multiple gross anterior epibulbar nodules right eye, submucosal masses nasal septum trachea, no lymphadenopathy during 12-year follow-up. The patient underwent ophthalmological,...
Purpose: Treatment of corneal neovascularization can lead to vessel regression and recovery transparency. Here, we examined the response cornea a repeated stimulus after initial comparing second wave with first. Methods: Corneal was induced by surgical suture placement in rat for 7 days, followed removal 30-day period. Corneas were then re-sutured an additional 4 days. Longitudinal slit-lamp imaging, vivo confocal microscopy, microarray analysis global gene expression conducted assess...
Inhibiting pathologic angiogenesis can halt disease progression, but such inhibition may offer only a temporary benefit, followed by tissue revascularization after treatment stoppage. This revascularization, however, occurs largely unknown phenotypic changes in vessels. To investigate the dynamics of vessel reconfiguration during we developed model reversible murine corneal permitting longitudinal examination same vasculature. Following 30 days inhibition, two types vascular structure were...
Angiogenesis as a pathological process in the eye can lead to blindness. In cornea, suppression of angiogenesis by anti-VEGF treatment is only partially effective while steroids, although treating inflammation and angiogenesis, have broad activity leading undesirable side effects. this study, genome-wide expression was investigated suture-induced corneal neovascularization model rats, investigate factors differentially targeted dexamethasone anti-Vegf. Topical with either rat-specific...
Background Nutritional visual defects are apparently uncommon nowadays in developed nations. Retinal change-related caused by hypovitaminoses may be underdiagnosed. Aim of the study To investigate retinal structural and functional changes a patient with multivitamin deficiency before during vitamin supplementation. Methods A 51-year-old female had been on vegetarian diet as child, restrict vegan last 2 years, developing severe bilateral deterioration function polyneuropathy. Blood test...
Abstract Therapeutics against pathologic new blood vessel growth, particularly those targeting vascular endothelial growth factor (VEGF) are of enormous clinical interest. In the eye, where anti-VEGF agents in widespread use for treating retinal and corneal blindness, only partial or transient efficacy resistance to among major drawbacks. Conversely, corticosteroids have long been used ophthalmology their potency suppressing inflammation angiogenesis, but broad biological activity can give...
To report on the outcome of conventional therapy in patients with Coats' disease.Retrospective analysis charts thirteen disease.Mean age 9 male (70%) and 4 female (30%) was 17.7 (range, 5-33) years; one had bilateral disease. Eleven eyes retinal telangiectasia exudation were treated argon laser photocoagulation alone or associated cryotherapy; mean follow up 32.5 (range,17-41) years. In four without foveal involvement (stage 2a) presenting visual acuity (VA) remained at 0.8 improved, whereas...
Background. Different disease-modifying therapies (DMT) for multiple sclerosis (MS) have disparate effects on disability outcomes. Sweden has a leading position globally in initiating high-efficacy DMT instead of escalating from 1st-line to DMT. With optical coherence tomography (OCT), retinal changes can be measured at few micrometer level. OCT been increasingly applied diagnosing MS and monitoring disease course therapeutic effect. Objective. We investigate the versus brain atrophy...
To present real-life data of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO) treated bevacizumab (BVZ); determine the possible influence epiretinal membrane (ERM) on treatment efficacy; and compare outcomes in a treat-and-extend regimen (TER) versus pro re nata (PRN).We carried out retrospective analysis 58 eyes (56 patients) new-onset CRVO only intravitreal according TER or PRN. Outcome measures were best-corrected visual acuity (BCVA) thickness (CRT) at...
Objective: We report that lumbar puncture (LP) with removal of cerebrospinal fluid (CSF) induced rebound intracranial hypertension increased papilledema as monitored by optical coherence tomography (OCT). Background: Severe causes visual field loss and central vision damage if untreated. Fundoscopy is a key to diagnose papilledema, but not sensitive enough monitor therapeutic effects. Methods: OCT was applied follow 24-year-old woman headache, dysfunction, severe bilateral elevated CSF...
Summary Purpose To identify prospective inhibitors of inflammatory angiogenesis that operate largely independent the VEGF pathway. Methods Inflammatory was induced in murine cornea using surgical sutures. Thereafter separate experiments were conducted to (i) prevent neovascularization an early phase by steroid (dexamethasone) or anti‐VEGFA therapy, and (ii) regress existing neovessels removal initial stimulus. Phenotypic changes examined vivo corneal imaging, whole‐transcriptome expression...
Background: Optic neuritis (ON) is an inflammatory condition of the optic nerve. ON associated with development demyelinating diseases central nervous system (CNS). CNS lesions visualized by magnetic resonance imaging (MRI) and finding oligoclonal IgG bands (OB) in cerebrospinal fluid (CSF) are used to stratify risk MS after a "first" episode ON. However, diagnosis absence typical clinical manifestations can be challenging. Methods Materials: Here we present three cases changes nerve...