A5016841820- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Cerebral Venous Sinus Thrombosis
- Bacterial Identification and Susceptibility Testing
- Intraoperative Neuromonitoring and Anesthetic Effects
- Ophthalmology and Eye Disorders
- Traumatic Ocular and Foreign Body Injuries
- Obstructive Sleep Apnea Research
- Herpesvirus Infections and Treatments
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Yersinia bacterium, plague, ectoparasites research
- Circadian rhythm and melatonin
- Toxoplasma gondii Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Visual perception and processing mechanisms
- Syphilis Diagnosis and Treatment
Centre Hospitalier Universitaire de Grenoble
2016-2025
Université Grenoble Alpes
2015-2024
Inserm
2015-2024
Centre Hospitalier Universitaire de Toulouse
2023
Hôpital Albert Michallon
2006-2023
Université de Toulouse
2023
Grenoble Institute of Neurosciences
2022
CHU Dijon Bourgogne
2012-2021
Hôpital Saint-Antoine
2020
Sorbonne Université
2020
Nonophthalmologist physicians do not confidently perform direct ophthalmoscopy. The use of artificial intelligence to detect papilledema and other optic-disk abnormalities from fundus photographs has been well studied.We trained, validated, externally tested a deep-learning system classify optic disks as being normal or having 15,846 retrospectively collected ocular that had obtained with pharmacologic pupillary dilation various digital cameras in persons multiple ethnic populations. Of...
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
To evaluate newly diagnosed non-arteritic anterior ischaemic optic neuropathy (NAION) patients for the existence of an associated sleep apnoea syndrome.
Purpose.: To evaluate the regional structure-function relationship between visual field sensitivity and retinal nerve fiber layer (RNFL) thickness optic head (ONH) measurements using spectral-domain optical coherence tomography (SD-OCT). Methods.: Prospective cross-sectional study conducted on patients with glaucoma, suspected healthy subjects. Eyes were tested Cirrus OCT standard achromatic perimetry. RNFL of 12 peripapillary 30° sectors, neuroretinal rim extracted from 36 scans, Bruch...
The deterioration of sleep in the older population is a prevalent feature that contributes to decrease quality life. Inappropriate entrainment circadian clock by light considered contribute alteration structure and rhythms elderly. present study investigates effects aging on non-visual spectral sensitivity tests hypothesis disturbances are related decreased transmittance. In within-subject design, eight aged five young subjects were exposed at night 60 minute monochromatic stimulations 9...
Previous studies on animal models suggested that visual areas involved in motion processing could undergo important cortical reorganizations following retinal damages. This have major implications for patients suffering from macular degeneration (MD), the leading cause of vision loss older adults. Here, we performed fMRI recordings a group maculopathy (including individuals age-related or Stargardt's Disease) and control to characterize network MD determine whether this undergoes significant...
To evaluate eubacterial PCR compared with conventional cultures for detection and identification of bacterial agents in ocular samples from patients acute postcataract endophthalmitis.Broad-range amplification was used, followed by direct DNA sequencing (aqueous humor, vitreous tap or vitrectomy) 100 consecutive presenting endophthalmitis. Bacterial were performed on the same using traditional methods (brain-heart infusion broth).At time admission, rate not significantly different between...
Glaucoma is a widespread ocular disease and major cause of blindness characterized by progressive, irreversible damage the optic nerve. Although degenerative loss retinal ganglion cells (RGC) visual deficits associated with glaucoma have been extensively studied, we hypothesize that will also lead to alteration circadian timing system. Circadian non-visual responses light are mediated specialized subset melanopsin expressing RGCs provide photic input mammalian endogenous clock in...
To characterize the nyctohemeral rhythm of intraocular pressure (IOP) and ocular perfusion (OPP) in patients with newly diagnosed, untreated normal tension glaucoma (NTG).Twenty-seven suspected NTG were prospectively included underwent 24-hour monitoring IOP blood (BP), polysomnography, nailfold capillaropathy. The rhythms IOP, BP, OPP modeled a nonlinear least-squares, dual-harmonic regression procedure, studying mean value, acrophase, nadir amplitude each rhythm. Nonparametric tests used...
This study evaluates a new device that has been proposed to continuously monitor intraocular pressure (IOP) over 24 hours.To evaluate 24-hour IOP rhythm reproducibility during repeated continuous monitoring with noncontact tonometry (NCT) and contact lens sensor (CLS) in healthy participants.Cross-sectional of 12 young volunteers at referral center chronobiology.Participants were housed sleep laboratory underwent four sessions measurements 6-month period. After initial randomized...
<h3>Importance</h3> The prevalence of obstructive sleep apnea syndrome (OSAS) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) and its influence on second eye involvement is not well known. <h3>Objective</h3> To evaluate the OSAS NAION risk factors involvement. <h3>Design, Setting, Participants</h3> In this cohort study, we examined 118 referred to a tertiary care center from January 1, 2003, through December 31, 2010. <h3>Exposures</h3> Patients underwent...
Objective To evaluate the performance of a deep learning system (DLS) in classifying severity papilledema associated with increased intracranial pressure on standard retinal fundus photographs. Methods A DLS was trained to automatically classify 965 patients (2,103 mydriatic photographs), representing multiethnic cohort confirmed elevated pressure. Training performed 1,052 photographs mild/moderate (MP) and 1,051 severe (SP) classified by panel experts. The that 3 independent...
Purpose.: We evaluated changes in anterior chamber (AC) morphology and iris volume induced by physiological mydriasis fellow eyes of acute angle-closure patients, age-, sex-, central AC depth-matched primary suspects (PACS). Methods.: In our study, 21 patients with angle closure; 40 PACS eyes; age- sex-matched normal open-angle were imaged using a Pentacam segment optical coherence tomography (AS-OCT) under light conditions, after 5 minutes darkness AS-OCT. Iris was estimated AS-OCT...
<h3>Importance</h3> Although rare, postoperative endophthalmitis in patients undergoing cataract surgery can lead to anatomical or functional loss of the eye. Therapeutic strategies such as antibiotic prophylaxis and microbiological diagnosis are more effective with a target patient population. New prospective data needed identify prognostic factors. <h3>Objective</h3> To baseline factors visual prognosis acute bacterial after surgery. <h3>Design</h3> Prospective study consecutive surgery,...
•The Brain and Optic Nerve Study Artificial Intelligence (BONSAI) deep learning system was able to reliably identify papilledema normal optic discs on photographs obtained in the Fundus photography vs Ophthalmoscopy Trial Outcomes Emergency Department (FOTO-ED) studies.•This previously trained high-quality mydriatic fundus performed very well nonmydriatic ocular photographs.•Our has excellent potential as a diagnostic aid emergency departments nonophthalmology clinics equipped with cameras....
To determine the change in intraocular pressure (IOP) due to postural changes young healthy volunteers.Intraocular was measured using a calibrated Pulsair noncontact tonometer both eyes of 25 female volunteers sitting position and after 1, 3, 10 minutes supine position. In second part experiment (a 7-day -6 degrees head-down tilt [HDT]), IOP (at 8 am, 12 am 6 pm) corneal thickness (12 am) were monitored before, during, HDT period. Blood pressure, hematocrit, plasma volume osmolality,...