Luca Cimino
A5084166303- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Vasculitis and related conditions
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- Glaucoma and retinal disorders
- Cell Adhesion Molecules Research
- Infectious Diseases and Tuberculosis
- Ocular Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune and Inflammatory Disorders Research
- Sarcoidosis and Beryllium Toxicity Research
- Psychiatry, Mental Health, Neuroscience
- Ophthalmology and Eye Disorders
- Inflammasome and immune disorders
- Herpesvirus Infections and Treatments
- Educational and Social Studies
- Intraocular Surgery and Lenses
- Spondyloarthritis Studies and Treatments
- IgG4-Related and Inflammatory Diseases
University of Modena and Reggio Emilia
2018-2025
Azienda Sanitaria Unità Locale di Reggio Emilia
2005-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Collaborative Group (United States)
2024
Ospedale Santa Maria
2004-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023
Universitat de Barcelona
2023
Azienda USL di Bologna
2021
University of the Republic of San Marino
2021
University of Bologna
2011-2019
An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in era biologics.The availability biologic agents human eye disease has altered practice patterns management uveitis. Current guidelines are insufficient assure optimal use noncorticosteroid systemic immunomodulatory agents.An international expert steering committee comprising 9 specialists (including both ophthalmologists and rheumatologists)...
To evaluate safety and efficacy of adalimumab in patients with noninfectious intermediate, posterior, or panuveitis.Phase 3, open-label, multicenter clinical trial extension (VISUAL III).Adults meeting treatment failure (TF) criteria who completed VISUAL I II (phase randomized, double-masked, placebo-controlled) without TF.Patients received 40 mg every other week. Interim follow-up data were described from III weeks 0 through 78.Disease quiescence, steroid-free active inflammatory...
Coronavirus disease 2019 (COVID-19) vaccines can cause transient local and systemic post-vaccination reactions. The aim of this study was to report uveitis other ocular complications following COVID-19 vaccination. included 42 eyes 34 patients (20 females, 14 males), with a mean age 49.8 years (range 18-83 years). cases reported were three herpetic keratitis, two anterior scleritis, five (AU), toxoplasma retinochoroiditis, Vogt-Koyanagi-Harada (VKH) reactivations, pars planitis, retinal...
Inflammatory adverse events following COVID-19 vaccination are being reported amidst the growing concerns regarding vaccine's immunogenicity and safety, especially in patients with pre-existing inflammatory conditions.Multinational case series of diagnosed an ocular event within 14 days collected from 40 centres over a 3 month period 2021.Seventy presented vaccination. The mean age was 51 years (range, 19-84 years). most common were anterior uveitis (n = 41, 58.6%), followed by posterior 9,...
To evaluate the frequency of visual manifestations at presentation in an Italian population-based cohort patients with biopsy-proven giant cell arteritis (GCA), and to investigate predictors for development permanent loss.We identified 136 Reggio Emilia (Italy) residents GCA diagnosed between 1986 2002. Medical records these were reviewed, demographic, clinical, laboratory data collected.Multivariate analysis multiple logistic regression models was performed identify best loss.Visual...
To evaluate the safety and efficacy of abatacept in patients with severe juvenile idiopathic arthritis (JIA)-related uveitis refractory or intolerant to immunosuppressive anti-tumor necrosis factor alpha (anti-TNFalpha) agents.Patients JIA-related anti-TNFalpha agents were treated intravenous (10 mg/kg monthly). Side effects, frequency flares, ocular complications before after treatment reported.Seven (6 females 1 male) a mean duration 11.6 years entered study. All had failed previous...
To evaluate the long-term efficacy and safety of infliximab in patients with Behçet's disease (BD) refractory bilateral posterior uveitis, to assess proportion relapse-free subjects through months 12 24.Open-label, multicentre, 24-month, prospective, follow up study on consecutive BD uveitis who had failed at least one immunosuppressive drug. At baseline received prednisolone 1 mg/Kg/day rapid tapering nine infusions (5 mg/kg) over a 12-month period. Non-responders after third infusion...
To evaluate the impact of traditional cardiovascular risk factors, carotid atherosclerosis and effect anti-platelet/anti-coagulant therapy on occurrence severe cranial ischaemic events (CIEs) in GCA.We identified 180 Reggio Emilia (Italy) residents with biopsy-proven GCA diagnosed between 1986 2005. We evaluated data demographics, clinical features, laboratory investigations, use atherosclerosis.Systemic signs/symptoms were significantly less frequent (P = 0.004) ESR C-reactive protein (CRP)...
To assess the visualization of choroidal granulomas (CG) by enhanced depth imaging optical coherence tomography (EDI-OCT) and to describe their EDI-OCT characteristics.Combined indocyanine green (ICG) angiography images 44 CG (sarcoid, tubercular, or Vogt-Koyanagi-Harada related) were reviewed. By ICG angiography, classified as full thickness partial small large. Two independent operators evaluated scans over record characteristics (full thickness/partial thickness, shape, reflectivity,...
This study evaluated the frequency, timing, and characteristics of flares in a large cohort Italian patients with biopsy-proven giant cell arteritis (GCA) to identify factors at diagnosis able predict occurrence flares. We 157 transmural GCA diagnosed followed Rheumatology Unit Reggio Emilia Hospital (Italy) for whom sufficient information was available from time until least 4 years follow-up. Fifty-seven (36.5%) experienced ≥1 Fifty-one (46.4%) 110 total (88 relapses 22 recurrences) were...
Purpose To provide recommendations for diagnosis of vitreoretinal lymphoma (VRL).Methods Literature was reviewed reports supporting the VRL. A questionnaire (Delphi 1 round) distributed to 28 participants. In second round 2), items not reaching consensus (75% agreement) were discussed finalize recommendations.Results Presenting symptoms include floaters and painless loss vision, vitreous cells organized into sheets or clumps. Retinal lesions are usually multifocal creamy/white in outer...
To investigate the epidemiology and clinical course of Behçet's disease (BD) over a 17-year period in defined area northern Italy.All patients with incident BD diagnosed (from January 1, 1988 to December 31, 2004) living Reggio Emilia were identified through following sources: physicians at Hospital, medical practitioners, community-based specialists. We all registered centralized index district database for rare diseases. Patients followed up from time diagnosis until either their death or...
Purpose: To standardize a nomenclature system for defining clinical phenotypes, and outcome measures reporting research data in patients with ocular tuberculosis (OTB).Methods: Uveitis experts initially administered further deliberated the survey an open meeting to determine propose preferred terms related OTB, describing phenotypes treatment outcomes.Results: The group of reached consensus on terming uveitis attributable (TB) as tubercular uveitis. working introduced SUN-compatible that...
Purpose: To analyze the role of polymerase chain reaction (PCR) ocular fluids in management tubercular (TB) anterior, intermediate, posterior, and panuveitis.Methods: In Collaborative Ocular Tuberculosis Study (COTS)-1 (25 centers, n = 962), patients with TB-related uveitis were included. 59 undergoing PCR intraocular (18 females; 53 Asian Indians) included.Results: (6.13%) COTS-1 underwent analysis. was positive for Mycobacterium TB 33 (23 males; all Indians). 26 negative males). Eight had...
Objective. The aim of this study was to assess the usefulness colour duplex sonography (CDS)-guided temporal artery biopsy (TAB) for diagnosis GCA in patients with suspected GCA.
Overreactivity and defensive behaviors in response to tactile stimuli are common symptoms autism spectrum disorder (ASD) patients. Similarly, somatosensory hypersensitivity has also been described mice lacking ASD-associated genes such as