A5009635395- Ocular Diseases and Behçet’s Syndrome
- Bone health and treatments
- Vasculitis and related conditions
- Cytomegalovirus and herpesvirus research
- Oral and Maxillofacial Pathology
- Retinal and Optic Conditions
- Clusterin in disease pathology
- Bone Tumor Diagnosis and Treatments
- Cancer, Lipids, and Metabolism
- Parathyroid Disorders and Treatments
- Nuclear Structure and Function
- Otitis Media and Relapsing Polychondritis
- Cardiac Imaging and Diagnostics
- Adrenal Hormones and Disorders
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Medical and Biological Sciences
- Cardiac, Anesthesia and Surgical Outcomes
- Systemic Lupus Erythematosus Research
- Acute Myocardial Infarction Research
- Hormonal Regulation and Hypertension
- Atrial Fibrillation Management and Outcomes
- Liver Diseases and Immunity
- Digestive system and related health
- Erythrocyte Function and Pathophysiology
Azienda Sanitaria Unità Locale di Reggio Emilia
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
Ospedale Santa Maria
2017-2023
Ospedale Sant'Anna
2018
Azienda Ospedaliera S.Maria
2017
Santa Maria Nuova Hospital
2010-2011
Istituto Nazionale Biostrutture e Biosistemi
2008-2009
University of Parma
2005-2009
Naples Anesthesia & Physician Associates
2006
University of Bologna
2005
Coronavirus disease 2019 (COVID-19) vaccines can cause transient local and systemic post-vaccination reactions. The aim of this study was to report uveitis other ocular complications following COVID-19 vaccination. included 42 eyes 34 patients (20 females, 14 males), with a mean age 49.8 years (range 18-83 years). cases reported were three herpetic keratitis, two anterior scleritis, five (AU), toxoplasma retinochoroiditis, Vogt-Koyanagi-Harada (VKH) reactivations, pars planitis, retinal...
Abstract In accordance with all the most recent international guidelines, variation of circulating levels cardiac troponins I and T, measured high-sensitivity methods (hs-cTnI hs-cTnT), should be used for detection acute myocardial injury. Recent experimental clinical evidences have demonstrated that evaluation hs-cTnI hs-cTnT variations is particularly relevant: a) differential diagnosis Acute Coronary Syndromes (ACS) in patients admitted to Emergency Department (ED); b) cardiovascular risk...
Non-infectious uveitis are intraocular inflammatory conditions caused by dysregulated activation of the immune response without any detectable infectious agents. The aim this study was to explore potential markers and therapeutic targets for two distinct types non-infectious associated with Behcet's disease (BD) Vogt Koyanagi Harada (VKH) disease. Concentrations 27 cytokines were investigated in aqueous humor (AH) samples from patients active versus healthy controls (HC) (n = 10...
A subset of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) developed a condition hyper-inflammation, which can cause multi-organ damage and the more forms disease 2019 (COVID-19). Mesenchymal stem cells (MSCs) promote tissue regeneration modulate immune responses and, thus, have rational requirements to be used counteract SARS-CoV-2-induced pneumonia hyper-inflammation. The aim present study was gain insight into possible mechanisms action MSCs obtained...
Abstract The Clusterin (CLU) gene produces different forms of protein products, which vary in their biological properties and distribution within the cell. Both extra‐ intracellular CLU regulate cell proliferation apoptosis. Dis‐regulation expression occurs many cancer types, including prostate cancer. role that plays tumorigenesis is still unclear. We found over‐expression inhibited induced apoptosis cells. Here we show depletion affects growth PC‐3 Following siRNA targeting all mRNA...
Adrenal venous sampling (AVS) is the gold standard for identification of unilateral primary aldosteronism (PA), but technically difficult. The aim our study was to assess whether intraprocedural cortisol measurement (IPCM) increases AVS success rate. Twenty-five consecutive PA patients underwent cosyntropin-stimulated AVS. Cortisol measured immediately in a first set samples drawn from adrenal veins and inferior vena cava. selectivity criterion an vein-to-inferior cava ratio ≥5. If bilateral...
The Italian Society of Clinical Biochemistry (SIBioC) and the Section European Ligand Assay (ELAS) have recently promoted a multicenter study (Italian hs-cTnI Study) with aim to accurately evaluate analytical performances reference values most popular cTnI methods commercially available in Italy. this article is report results Study concerning evaluation 99th percentile URL change (RCV) around Access method.Heparinized plasma samples were collected from 1306 healthy adult volunteers by 8...
Background Prostate cancer (CaP) is one of the most relevant causes death in Western Countries. Although detection CaP at early curable stage highly desirable, actual screening methods present limitations and new molecular approaches are needed. Gene expression analysis increases our knowledge about biology may render novel tools, but identification accurate biomarkers for reliable diagnosis a real challenge. We describe here diagnostic power 8-genes signature: ornithine decarboxylase (ODC),...
Serial measurements of cardiac troponin are recommended by international guidelines to diagnose myocardial infarction (MI) since 2000. However, some relevant differences exist between the three different published 2020 and 2021 for management patients with chest pain no ST-segment elevation. In particular, there is agreement on cut-offs or absolute change values non-ST-segment elevation MI (NSTEMI). Other controversial issues concern diagnostic accuracy cost-effectiveness cut-off most rapid...
Abstract Clusterin (CLU), whose role is still debated, differentially regulated in several patho‐physiological processes and invariably induced during apoptosis. In heat shock response, CLU considered a stress‐inducible, pro‐survival/cyto‐protective factor via an HSE element present his promoter. both human prostate PNT1A PC‐3 epithelial cells we found that apoptotic stimuli nuclear localization of (nCLU), overexpression nCLU pro‐apoptotic. We show here time‐course accumulation kinetic...
We previously found that human prostate cancer (CaP) progression is accompanied by differential expression of a panel 8 informative genes, some which are metabolically related. Gene profiling focused on this 8-gene pack northern blot analysis in combination with standard clinical information provided reliable prognostic prediction CaP. For better insight into the potential signature tumor detection/classification and therapeutic response, we determined, qPCR, these genes TRAMP mice model CaP...
GCA is characterized by arterial remodelling driven inflammation. IL-22 an attractive cytokine which acts at the crosstalk between immune and stromal cells. We hypothesized that might be induced in involved disease pathogenesis.Patients subjected to temporal artery biopsies (TABs) naïve from therapy were enrolled: 27 biopsy-proven GCA, 8 biopsy-negative 21 non-GCA patients. Expression of was determined TABs immunohystochemistry, plasma ELISA, peripheral blood mononuclear cells real-time PCR...
Abstract It is well known that the results of immunoassay methods can be affected by specific or non-specific interferences, ranging from 0.4% to 4.0%. The presence interference may greatly compromise accuracy analyses causing an error in measurement, producing false-positive false-negative results. From a clinical point view, these analytical errors have serious implications for patient care because they cause misdiagnosis inappropriate treatment. Unfortunately, it very difficult task...
Anterior segment optical coherence tomography (AS-OCT) allows the explore not only anterior chamber but also front part of vitreous cavity. Our cross-sectional single-centre study investigated whether AS-OCT can distinguish between involvement due to vitreoretinal lymphoma (VRL) and vitritis in uveitis. We studied images from 28 patients (11 with biopsy-proven VRL 17 differential diagnosis uveitis) using publicly available radiomics software written MATLAB. Patients were divided into two...