A5066659437- Vasculitis and related conditions
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Cell Adhesion Molecules Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Rheumatoid Arthritis Research and Therapies
- Ocular Diseases and Behçet’s Syndrome
- Systemic Sclerosis and Related Diseases
- Spondyloarthritis Studies and Treatments
- Atherosclerosis and Cardiovascular Diseases
- IgG4-Related and Inflammatory Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Eosinophilic Disorders and Syndromes
- Retinal and Optic Conditions
- Renal Diseases and Glomerulopathies
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Psoriasis: Treatment and Pathogenesis
- Immunodeficiency and Autoimmune Disorders
- Skin Diseases and Diabetes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Chemokine receptors and signaling
- Cerebrovascular and Carotid Artery Diseases
Azienda Sanitaria Unità Locale di Reggio Emilia
2015-2024
University of Modena and Reggio Emilia
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2024
Medizinische Hochschule Brandenburg Theodor Fontane
2024
Azienda Ospedaliera S.Maria
2011-2023
Santa Maria Nuova Hospital
2006-2023
Center for Rheumatology
2007-2020
ASM International
2014-2018
Ospedale Santa Maria
2007-2017
Villa Maria Hospital
2017
Abstract Objective Behçet's disease ( BD ) is a chronic, relapsing, inflammatory vascular with no pathognomonic test. Low sensitivity of the currently applied International Study Group ISG clinical diagnostic criteria led to their reassessment. Methods An Team for Revision Criteria (from 27 countries) submitted data from 2556 clinically diagnosed patients and 1163 controls ‐mimicking diseases or presenting at least one major sign. These were randomly divided into training validation sets....
The objective of this study was to develop EULAR/ACR classification criteria for polymyalgia rheumatica (PMR). Candidate were evaluated in a 6-month prospective cohort 125 patients with new onset PMR and 169 non-PMR comparison subjects conditions mimicking PMR. A scoring algorithm developed based on morning stiffness >45 minutes (2 points), hip pain/limited range motion (1 point), absence RF and/or ACPA peripheral joint pain point). score ≥4 had 68% sensitivity 78% specificity discriminating...
Abstract The objective of this study was to develop European League Against Rheumatism/American College Rheumatology classification criteria for polymyalgia rheumatica (PMR). Candidate were evaluated in a 6‐month prospective cohort 125 patients with new‐onset PMR and 169 non‐PMR comparison subjects conditions mimicking PMR. A scoring algorithm developed based on morning stiffness >45 minutes (2 points), hip pain/limited range motion (1 point), absence rheumatoid factor and/or...
Aims The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled data. Methods Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. Results Of 3067 cases, 69% female. most common subtype dermatomyositis (DM) (31%). Smoking more frequent in connective...
Antisynthetase syndrome (ASSD) is a rare clinical condition that characterized by the occurrence of classic triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether presence ARS might affect presentation, evolution, outcome ASSD. In this study, we retrospectively recorded time onset, characteristics, clustering triad findings, survival...
To evaluate the frequency of visual manifestations at presentation in an Italian population-based cohort patients with biopsy-proven giant cell arteritis (GCA), and to investigate predictors for development permanent loss.We identified 136 Reggio Emilia (Italy) residents GCA diagnosed between 1986 2002. Medical records these were reviewed, demographic, clinical, laboratory data collected.Multivariate analysis multiple logistic regression models was performed identify best loss.Visual...
<b>BACKGROUND AND PURPOSE:</b> Wernicke encephalopathy (WE) is a severe neurologic disorder resulting from dietary vitamin B<sub>1</sub> deficiency. This study was undertaken to analyze and compare MR imaging findings manifestations at clinical presentations of patients with WE without history alcohol abuse. <b>MATERIALS METHODS:</b> were identified using diagnostic data bases. Fifty-six (29 females, 27 males) diagnosed between 1999 2008 who improved within 1 month the onset thiamine...
We reviewed 888 temporal artery biopsies (TAB) performed in 871 patients a single institution from January 1986 to December 2013. Forty-four (4.9%) were inadequate, 490 (55.2%) devoid of inflammation and considered negative, 354 (39.9%) showed positive. On the basis localization inflammation, positive TABs further classified into 4 categories: small vessel vasculitis (SVV), which was limited periadventitial vessels muscular coat, with sparing (32 cases, 9% biopsies); vasa vasorum (VVV),...
To evaluate the impact of traditional cardiovascular risk factors, carotid atherosclerosis and effect anti-platelet/anti-coagulant therapy on occurrence severe cranial ischaemic events (CIEs) in GCA.We identified 180 Reggio Emilia (Italy) residents with biopsy-proven GCA diagnosed between 1986 2005. We evaluated data demographics, clinical features, laboratory investigations, use atherosclerosis.Systemic signs/symptoms were significantly less frequent (P = 0.004) ESR C-reactive protein (CRP)...
This study evaluated the frequency, timing, and characteristics of flares in a large cohort Italian patients with biopsy-proven giant cell arteritis (GCA) to identify factors at diagnosis able predict occurrence flares. We 157 transmural GCA diagnosed followed Rheumatology Unit Reggio Emilia Hospital (Italy) for whom sufficient information was available from time until least 4 years follow-up. Fifty-seven (36.5%) experienced ≥1 Fifty-one (46.4%) 110 total (88 relapses 22 recurrences) were...
To characterize the 10 year relationship between anti-transcriptional intermediary factor 1 antibody (anti-TIF1-Ab) positivity and cancer onset in a large UK-based adult DM cohort.Data from anti-TIF1-Ab-positive/-negative adults with verified diagnoses of UK Myositis Network register were analysed. Each patient was followed up until they developed cancer. Kaplan-Meier methods Cox proportional hazard modelling employed to estimate cumulative incidence.Data 263 cases analysed, total 3252...
To identify patients with VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome) from a single-center cohort of Italian vasculitis, using clinically oriented phenotype-first approach.We retrospectively reviewed the clinical records 147 consecutive male followed up in our vasculitis clinic 2013 to date. All diagnosis and treatment-resistant manifestations inflammation, persistently elevated inflammation markers, hematologic abnormalities were identified. Bone...
To evaluate the presence and extent of large-vessel inflammation in patients with chronic periaortitis (CP) using (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET).A consecutive case series consisting 7 CP seen over a 3-year period control group 14 malignancy were evaluated FDG-PET. For every we selected 2 age- sex-matched controls who underwent PET imaging for malignancy. The diagnosis was made by means computed tomography. performed at before therapy started. Measurement...
Abstract Objective To test the hypothesis that oral creatine supplements with exercise are more effective than alone in improving muscle function patients established dermatomyositis or polymyositis receiving chronic medical therapies who clinically weak yet stable. Methods In a 6‐month, 2‐center, double‐blind, randomized controlled trial, were to receive (8 days, 20 gm/day then 3 gm/day) placebo. All followed home program. The primary outcome was aggregate functional performance time...
To evaluate the inflammatory involvement of cervical interspinous bursae in patients with polymyalgia rheumatica (PMR) using MRI.In all, 12 consecutive, untreated new PMR were investigated. Five fibromyalgia, two osteoarthritis and six spondyloarthritis neck pain served as controls. MRI spine was performed all case 13 control patients. Two four pelvic girdle also had lumbar spine.MRI evidence bursitis found PMR, three psoriatic spondylitis one osteoarthritis. A moderate to marked (grade...
To investigate the epidemiology and clinical course of Behçet's disease (BD) over a 17-year period in defined area northern Italy.All patients with incident BD diagnosed (from January 1, 1988 to December 31, 2004) living Reggio Emilia were identified through following sources: physicians at Hospital, medical practitioners, community-based specialists. We all registered centralized index district database for rare diseases. Patients followed up from time diagnosis until either their death or...