A5074188047- Polyamine Metabolism and Applications
- Amino Acid Enzymes and Metabolism
- Clusterin in disease pathology
- Cannabis and Cannabinoid Research
- Cancer, Lipids, and Metabolism
- Biomarkers in Disease Mechanisms
- Tea Polyphenols and Effects
- Parathyroid Disorders and Treatments
- Trace Elements in Health
- Nuclear Structure and Function
- Aquaculture Nutrition and Growth
- Magnesium in Health and Disease
- Muscle metabolism and nutrition
- Microtubule and mitosis dynamics
- Telomeres, Telomerase, and Senescence
- Aldose Reductase and Taurine
- RNA and protein synthesis mechanisms
- Phytoestrogen effects and research
- Cell death mechanisms and regulation
- Medicinal Plants and Bioactive Compounds
- TGF-β signaling in diseases
- Estrogen and related hormone effects
- Pancreatic function and diabetes
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
University of Modena and Reggio Emilia
2011-2023
Istituto Nazionale Biostrutture e Biosistemi
2010-2012
University of Parma
1983-2006
University of Bologna
1979-2005
Sigma Tau (Italy)
1979
Sigma-Tau (Switzerland)
1979
Magnesium (Mg) is crucial for bone health. Low concentrations of Mg inhibit the activity osteoblasts while promoting that osteoclasts, with final result inducing osteopenia. Conversely, little known about effects high extracellular on osteoclasts and osteoblasts. Since differentiation activation these cells coordinated by vitamin D₃ (VD3), we investigated Mg, as well its impact VD3 activity, in cells. U937 were induced to osteoclastic presence supra-physiological (>1 mM) Mg. The effect was...
Among endocrine disruptors, the xenoestrogen bisphenol A (BPA) deserves particular attention due to widespread human exposure. Besides hormonal effects, BPA has been suspected be involved in breast and prostate carcinogenesis, which share similar estrogen-related mechanisms. We previously demonstrated that administration of female mice results formation DNA adducts proteome alterations mammary tissue. Here, we evaluated ability BPA, given with drinking water, induce a variety biomarker male...
In human dermal fibroblasts, brought to quiescence (G 0 ) by serum starvation, the S phase peaked 24 h and G 2 /M phases 36 after re‐addition. Under same conditions, ornithine decarboxylase mRNA at 12 h, decreased markedly in remained low until 48 h. Conversely, antizyme transcript dropped its lowest level while reaching highest values between Ornithine activity followed essentially pattern of mRNA, but relative changes were much greater. ‐Adenosylmethionine enzyme also around decreasing...
Abstract Partial hemitransection at the mesodiencephalic junction in rat increased striatal and nigral putrescine concentrations on lesioned side for least 168 h, with maximal increases between 24 48 h. Spermidine spermine levels declined h striatum, rising above control values further In substantia nigra, they remained unchanged first then by Cadaverine striatum also On intact but to a much lesser extent (at nigra). Ornithine decarboxylase diamine oxidase activities showed of side, whereas...
Rationale: Cigarette smoke causes injury to lung fibroblasts, partly by means of oxidative stress, and stress can lead various diseases, such as chronic obstructive pulmonary disease. Clusterin is a widely distributed protein with many functions, including cellular protection in response stress.Objectives: To determine whether clusterin involved the defense against cigarette smoke, we investigated effects extract on expression its protective effect, if any, stress.Methods: Fibroblasts were...
We previously found that human prostate cancer (CaP) progression is accompanied by differential expression of a panel 8 informative genes, some which are metabolically related. Gene profiling focused on this 8-gene pack northern blot analysis in combination with standard clinical information provided reliable prognostic prediction CaP. For better insight into the potential signature tumor detection/classification and therapeutic response, we determined, qPCR, these genes TRAMP mice model CaP...
We have previously reported that cyclical phases of accumulation and depletion polyamines occur during cell-cycle progression. Regulatory ornithine decarboxylase (ODC) catalyses the first step polyamine biosynthesis. Ornithine antizyme (OAZ), induced by high levels, inhibits ODC activity prevents extracellular uptake. Spermidine/spermine N1-acetyltransferase (SSAT) regulates degradation/excretion pathway. Here we show 24 h transient transfection immortalized human prostatic epithelial cells...
The effects of a partial hemitransection at the meso‐diencephalic level, with or without chronic ganglioside GM1 treatment, have been evaulated on striatal polyamine levels, 7, 14 and 21 days after lesion, as well ability synthesis inhibitor alpha‐difluoromethylornithine (α‐DFMO) to modulate protective treatment against retrograde degeneration nigral dopamine (DA) nerve cell bodies (14 day time interval). levels were measured by high pressure liquid chromatography dansylation polyamines. DA...
We have previously reported that cyclical phases of accumulation and depletion polyamines occur during cell-cycle progression. Regulatory ornithine decarboxylase (ODC) catalyses the first step polyamine biosynthesis. Ornithine antizyme (OAZ), induced by high levels, inhibits ODC activity prevents extracellular uptake. Spermidine/spermine N1-acetyltransferase (SSAT) regulates degradation/excretion pathway. Here we show 24h transient transfection immortalized human prostatic epithelial cells...
Mitotic perturbations frequently lead to chromosome mis-segregation that generates genome instability, thereby triggering tumor onset and/or progression. Error-free mitosis depends on fidelity-monitoring systems ensure the temporal and spatial coordination of segregation. Recent investigations are focused mitotic DNA damage response (DDR) mis-segregations with aim developing more efficient anti-cancer therapies. We previously demonstrated trichoplein keratin filament binding protein (TpMs)...
In the ventral prostate of intact rat, clusterin mRNA is expressed in a small population cuboidal epithelial cells undergoing apoptosis, but not columnar comprising vast majority glandular epithelium. Upon castration, expression and apoptotic activity are turned off on ones. We show here that progressive enhancements abundance mRNA, occurring rat upon aging, based increases at expense DNA fragmentation, typical sign assayed both by agarose gel electrophoresis situ staining, was undetectable...
Clusterin (CLU) is a stress-activated glycoprotein, whose expression altered both in inflammation and cancer. Previously, we showed that abrogation of CLU cancer-prone mice (TRAMP) results the enhancement tumor spreading homing, concomitant with an enhanced NF- κ B. In present paper, carried out extensive experimental work by utilizing microarray gene data, as well vitro vivo models prostate cancer (PCa). Our demonstrated (i) significantly downregulated human PCa inversely correlates p65...