A5043298138- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Advanced Chemical Sensor Technologies
- Occupational exposure and asthma
- Effects and risks of endocrine disrupting chemicals
- Mercury impact and mitigation studies
- Toxic Organic Pollutants Impact
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Glutathione Transferases and Polymorphisms
- Chromium effects and bioremediation
- Analytical Chemistry and Chromatography
- Health, Environment, Cognitive Aging
- Occupational and environmental lung diseases
- Quality and Safety in Healthcare
- Inhalation and Respiratory Drug Delivery
- Metabolomics and Mass Spectrometry Studies
- Renal Diseases and Glomerulopathies
- Climate Change and Health Impacts
- Chronic Kidney Disease and Diabetes
- Pesticide Exposure and Toxicity
- Immunotoxicology and immune responses
- Trace Elements in Health
- Lung Cancer Treatments and Mutations
Health Affairs
2022
University of Parma
2010-2019
Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro
2015-2019
Istituto Giannina Gaslini
2015
University of Brescia
2014
Federal Emergency Management Agency
2014
University of Aberdeen
2010
University of Trnava
2010
In-Q-Tel
2009
Medica (Italy)
2006
Abstract Background Non-invasive diagnostic strategies aimed at identifying biomarkers of lung cancer are great interest for early detection. The aim this study was to set up a new method and quantifying volatile organic compounds (VOCs) in exhaled air patients with non-small cells (NSCLC), by comparing the levels those obtained from healthy smokers non-smokers, chronic obstructive pulmonary disease. VOC collection analyses were repeated three weeks after NSCLC underwent surgery. Methods...
To investigate the associations between Parkinson's disease and other degenerative parkinsonian syndromes environmental factors in five European countries.A case-control study of 959 prevalent cases parkinsonism (767 with disease) 1989 controls Scotland, Italy, Sweden, Romania Malta was carried out. Cases were defined using United Kingdom Disease Society Brain Bank criteria, those drug-induced or vascular dementia excluded. Subjects completed an interviewer-administered questionnaire about...
Lead, cadmium, mercury, and arsenic are common environmental pollutants in industrialized countries, but their combined impact on children's health is little known. We studied effects two main targets, the renal dopaminergic systems, > 800 children during a cross-sectional European survey. Control exposed were recruited from those living around historical nonferrous smelters France, Czech Republic, Poland. Children provided blood urine samples for determination of metals sensitive or...
The aims of the present study were (1) to evaluate whether individual aldehydes resulting from lipid peroxidation can be measured in exhaled breath condensate, (2) assess influence sampling procedures on aldehyde concentrations, and (3) compare levels patients with stable, moderate severe, chronic obstructive pulmonary disease those smoking nonsmoking control subjects. Aldehydes (malondialdehyde, hexanal, heptanal, nonanal) by liquid chromatography-tandem mass spectrometry all samples...
OBJECTIVES: The goal of this study was to assess long-term neurobehavioral effects associated with low airborne concentrations manganese in a ferroalloy plant. METHODS: During period forced cessation work (1 42 d) performance on tests simple reaction time, finger tapping, digit span, additions, symbol digit, and shapes comparison evaluated for 58 workers exposed from 1 28 (mean 13, SD 7) years manganese. Airborne total dust had been reduced the last 10 70-159 micrograms x m-3 (geometric...
The present study has been carried out in the framework of a collaborative research project on development new markers nephrotoxicity. A battery more than 20 potential indicators renal changes applied to 50 workers exposed lead (Pb) and control subjects. After application selection criteria 41 were eventually retained for final statistical analysis. average blood Pb concentration was 480 micrograms/l their mean duration exposure 14 years. tests included parameters capable detecting...
Abstract A method for the simultaneous determination of several classes aldehydes in exhaled breath condensate (EBC) was developed using liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (LC/APCI‐MS/MS). EBC is a biological matrix obtained by relatively new, simple and noninvasive technique provides an indirect assessment pulmonary status. The measurement represents biomarker effect oxidative stress caused smoke, disease, or strong oxidants like ozone....
Abstract Background Despite the widespread use of fractional exhaled nitric oxide (FE NO ) as a biomarker airways inflammation, there are no published papers describing normal FE values in large group healthy adults. Objective The aim this study was to establish adult reference according international guidelines. Methods measured 204 healthy, non-smoking adults with spirometry using on-line single-breath technique, and results were analysed chemiluminescently. Results main result significant...
Chromium is corrosive, cytotoxic, and carcinogenic for humans can induce acute chronic lung tissue toxicity. The aim of this study was to investigate Cr levels in exhaled breath condensate (EBC) workers exposed Cr(VI) assess their relationship with biochemical changes the airways by analyzing EBC biomarkers oxidative stress, namely, hydrogen peroxide (H2O2) malondialdehyde (MDA). samples were collected from 24 chrome-plating employed a plant both before after Friday work shift on following...
The aim of the present study was to compare aldehyde levels resulting from lipid peroxidation in exhaled breath condensate (EBC) and induced sputum (IS) supernatant subjects with asthma chronic obstructive pulmonary disease (COPD). Aldehydes (malondialdehyde (MDA), acrolein, n -hexanal (C6), -heptanal (C7), -nonanal (C9), 4-hydroxynonenal (HNE) 4-hydroxyhexenal (HHE)) both biological fluids were measured by liquid chromatography-tandem mass spectrometry. MDA concentrations 132.5 nM...
Several markers of renal changes have been measured in a cohort 50 workers exposed to elemental mercury (Hg) and control workers. After application selection criteria 44 49 were retained for the final statistical analysis. Exposed excreted on average 22 micrograms Hg/g creatinine their mean duration exposure was 11 years. Three types studied--namely, functional (creatinine beta 2-microglobulin serum, urinary proteins low or high molecular weight); cytotoxicity (tubular antigens enzymes...
Abstract A neuropsychological test battery was administered to 50 workers exposed styrene and sex‐, intelligence‐, age‐matched controls. The main metabolites, ie, mandelic acid (MA) phenylglyoxylic (PGA), were measured as exposure indices in the urine collected on Saturday mornings, just before testing. Exposure‐response exposure‐effect relationships found between intensity of (as reflected by sum MA PGA) scores tests. Verbal learning skills significantly impaired with a PGA higher than 150...
To investigate associations of Parkinson's disease (PD) and parkinsonian syndromes with polymorphic genes that influence metabolism either foreign chemical substances or dopamine to seek evidence gene-environment interaction effects modify risk.A case-control study 959 prevalent cases parkinsonism (767 PD) 1989 controls across five European centres. Occupational hygienists estimated the average annual intensity exposure solvents, pesticides metals, (iron, copper, manganese), blind status....
A 90-day toxicological study was carried out administering equimolar doses of either 3-MCPD (respectively 29.5, 7.37, and 1.84 mg/kg b.w. per day) or dipalmitate 156.75, 39.19, 9.78 to both male female rats (10 animals group).Urinary mercapturate were used monitor exposure its dipalmitate, assess the bioavailability latter (equimolar gave rise urinary metabolites lower by 30 % as compared administration 3-MCPD).Histopathological examination confirmed that kidney and, in rats, testes are...
In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction nanoparticles with body tissues, particular within cardiovascular system. Attention has recently focused on link between environmental pollution and diseases. Nanoparticles <50 nm size are known pass alveolar–pulmonary barrier, enter into bloodstream induce inflammation, but direct pathogenic mechanisms still need be evaluated. We thus our attention titanium dioxide (TiO2)...