A5067118870- Air Quality and Health Impacts
- Advanced Chemical Sensor Technologies
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- Asthma and respiratory diseases
- Toxic Organic Pollutants Impact
- Occupational exposure and asthma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Effects and risks of endocrine disrupting chemicals
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Function and Risk Factors
- Cardiovascular Effects of Exercise
- Inhalation and Respiratory Drug Delivery
- Mercury impact and mitigation studies
- Immunotherapy and Immune Responses
- Nanoparticles: synthesis and applications
- Air Quality Monitoring and Forecasting
- Chromium effects and bioremediation
- Occupational and environmental lung diseases
- Restless Legs Syndrome Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Disease and Adiposity
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Cardiac Valve Diseases and Treatments
University of Parma
2015-2024
Istituto Nazionale per l'Assicurazione Contro gli Infortuni sul Lavoro
2011-2019
University of Cambridge
2017
Lund University
2017
Sechenov University
2017
Whyteman’s Brae Hospital
2017
University of Florence
2016
Accident Compensation Corporation
2011-2016
Cancer Research And Biostatistics
2014
Federal Emergency Management Agency
2014
Abstract Background Non-invasive diagnostic strategies aimed at identifying biomarkers of lung cancer are great interest for early detection. The aim this study was to set up a new method and quantifying volatile organic compounds (VOCs) in exhaled air patients with non-small cells (NSCLC), by comparing the levels those obtained from healthy smokers non-smokers, chronic obstructive pulmonary disease. VOC collection analyses were repeated three weeks after NSCLC underwent surgery. Methods...
Purpose: The success of immune checkpoint inhibitors strengthens the notion that tumor growth and regression are regulated. To determine whether distinct tissue microenvironments differentially affect clinical outcome in non-small cell lung cancer (NSCLC), an extended analysis PD-L1 tumor-infiltrating lymphocytes (TIL) was performed.Experimental Design: Samples from resected adenocarcinoma (ADC 42), squamous carcinoma (SCC 58), 26 advanced diseases (13 ADC 13 SCC) treated with nivolumab were...
Background: Sex differences have been demonstrated in the acute phase of coronavirus disease 2019 (COVID-19). Women (F) were found to be less prone develop a severe than men (M), but few studies assessed sex-differences Long-COVID-19 syndrome. Methods: The aim this prospective/retrospective study was characterize long-term consequences infection based on sex. For purpose, we enrolled 223 patients (89 F and 134 M) who infected by SARS-CoV-2. In illness, reported following symptoms more...
Background— Behçet disease (BD) is a systemic vasculitis with broad range of organ involvement, characterized by multisystemic, immune-inflammatory disorder involving vessels all sizes and often complicated thrombosis. Systemic redox imbalance circulating neutrophil hyperactivation have been observed in BD patients are thought to be responsible for impaired coagulation. We here focused on the pathogenetic mechanisms potentially linking immune cell activation thrombosis, specifically examined...
Chromium is corrosive, cytotoxic, and carcinogenic for humans can induce acute chronic lung tissue toxicity. The aim of this study was to investigate Cr levels in exhaled breath condensate (EBC) workers exposed Cr(VI) assess their relationship with biochemical changes the airways by analyzing EBC biomarkers oxidative stress, namely, hydrogen peroxide (H2O2) malondialdehyde (MDA). samples were collected from 24 chrome-plating employed a plant both before after Friday work shift on following...
The aim of the present study was to compare aldehyde levels resulting from lipid peroxidation in exhaled breath condensate (EBC) and induced sputum (IS) supernatant subjects with asthma chronic obstructive pulmonary disease (COPD). Aldehydes (malondialdehyde (MDA), acrolein, n -hexanal (C6), -heptanal (C7), -nonanal (C9), 4-hydroxynonenal (HNE) 4-hydroxyhexenal (HHE)) both biological fluids were measured by liquid chromatography-tandem mass spectrometry. MDA concentrations 132.5 nM...
In light of recent developments in nanotechnologies, interest is growing to better comprehend the interaction nanoparticles with body tissues, particular within cardiovascular system. Attention has recently focused on link between environmental pollution and diseases. Nanoparticles <50 nm size are known pass alveolar–pulmonary barrier, enter into bloodstream induce inflammation, but direct pathogenic mechanisms still need be evaluated. We thus our attention titanium dioxide (TiO2)...
Objective Adult‐onset IgA vasculitis (Henoch‐Schönlein) (Ig AV ) is a rare systemic characterized by IgA1‐dominant deposits. The treatment of adult‐onset Ig controversial and based on the combination glucocorticoids immunosuppressive agents, but many patients have refractory or relapsing disease despite treatment. Rituximab ( RTX B cell–depleting antibody proven efficacy in antineutrophil cytoplasmic antibody–associated vasculitis. We undertook this study to test safety multicenter cohort...
Traumatic parenchymal mass lesions are common sequelae of traumatic brain injuries (TBIs). They occur in up to 8.2% all TBI cases and 13%-35% severe cases, they account for 20% surgical intracranial lesions. Controversy exists concerning the association between radiological clinical evolution contusions. The aim this study was identify predictors unfavorable outcome, analyze contusions, evaluate specific indications surgery.In a retrospective, multicenter study, patients with contusions were...
Idiopathic retroperitoneal fibrosis (RPF) is a rare disease. Asbestos exposure has been proposed as risk factor for idiopathic RPF.To investigate the role of asbestos and other occupational agents (such silica, metals, organic solvents), well environmental smoking), their interactions potential factors RPF.Case-control study.National referral hospital RPF.90 patients with RPF 270 control participants matched age, sex, region residency.Occupational history was obtained using structured...
Lung cancer is a major cause of death in Western countries. Current screening methods are invasive and still lead to high percentage false positives. There is, therefore, need find biomarkers that increase the probability detecting lung early. MicroRNAs (miRNAs) stable molecules blood plasma exhaled breath condensate (EBC). We quantified miRNA-21 miRNA-486 expression from EBC samples patients with diagnosis non-small-cell (NSCLC) controls. was significantly higher NSCLC lower. This...
The development of innovative nanosystems opens new perspectives for multidisciplinary applications at the frontier between materials science and nanomedicine. Here we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer, tetracarboxyphenyl porphyrin derivative. We show that this is efficient source singlet oxygen cell oxidative stress when irradiated 6 MV X-Rays low doses...
Objective Since Behçet's syndrome (BS) is the prototype of inflammation‐induced thrombosis, immunosuppressants are recommended in place anticoagulants. We undertook this study to assess clinical efficacy and corticosteroid‐sparing effect adalimumab (ADA)–based treatment versus disease‐modifying antirheumatic drug (DMARD) therapy a large retrospective cohort patients with BS‐related venous thrombosis. Methods retrospectively collected data on 70 BS treated DMARDs or ADA‐based regimens (ADA...
Inadequate diet, physical activity, and sleep-related behaviors are potential risk factors for overweight obese, therefore we investigated the relations between body mass index (BMI) behavioral in a sample of Italian adolescents. Four hundred nine secondary school students (46% females, 12.5 ± 0.6 y.o.) were enrolled this cross-sectional study. Anthropometric measures, adherence to Mediterranean Diet (KIDMED), activity level (PAQ-C), sleep duration, daytime sleepiness (PDSS), quality,...