A5001880670- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Magnetism in coordination complexes
- Organometallic Compounds Synthesis and Characterization
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Metal-Catalyzed Oxygenation Mechanisms
- Synthesis and biological activity
- Radical Photochemical Reactions
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Mycotoxins in Agriculture and Food
- Metal-Organic Frameworks: Synthesis and Applications
- Carbohydrate Chemistry and Synthesis
- Liver Disease Diagnosis and Treatment
- Lanthanide and Transition Metal Complexes
- Chemical Synthesis and Analysis
- Liver Disease and Transplantation
- Sulfur-Based Synthesis Techniques
- Fungal Plant Pathogen Control
University of Parma
2015-2025
Consorzio Interuniversitario Reattività Chimica e Catalisi
2014-2022
In-Q-Tel
2013-2016
Istituto di Chimica Biomolecolare
2003-2011
Ospedale di Parma
2007-2009
Policlinico Universitario di Catania
2007-2009
Johannes Gutenberg University Mainz
2008
European Union
2007
Université Paris-Saclay
2003-2005
Laboratoire de Chimie
2003
New α-ketoglutaric acid thiosemicarbazone (H3ct) derivatives and their copper complexes were synthesized characterized by analytical spectroscopic (IR NMR) methods. For two of the ligands, Me-H3ct Allyl-H3ct, for a complex, [Cu(Me-Hct)(OH2)]n·2nH2O, X-ray structures also determined. In latter atom shows 4 + 1 pyramidal coordination, water oxygen appears in apical position, three basal positions are occupied SNO tridentate ligand fourth carboxylic an adjacent molecule that gives rise to...
Thiosemicarbazones display a wide antimicrobial activity by targeting bacteria, fungi, and viruses. Here, we report our studies on the antiviral of two thiosemicarbazone metal complexes, [bis(citronellalthiosemicarbazonato)nickel(II)] [aqua(pyridoxalthiosemicarbazonato)copper(II)] chloride monohydrate, against retroviruses HIV-1 HTLV-1/-2. Both compounds exhibit properties HIV but not HTLVs . In particular, copper complex shows most potent anti-HIV acting at post-entry steps viral cycle.
Vinylogy: Advances in asymmetric catalysis using the bifunctional cinchona alkaloid/thioureas enabled an umpolung of classical Cβ reactivity 3-alkylidene oxindoles, thus allowing development first and sole example a direct, organocatalytic vinylogous Michael (AVM) reaction with nitroolefins. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors. Please...
Modulation of the complex reactivity cyclohexenylidene malononitriles using diverse β-aryl-substituted enals and proper organocatalytic modalities resulted in divergent asymmetric reaction patterns to furnish angularly fused or bridged carbabicyclic frameworks. In particular, use remotely enolizable dicyanodienes 1, under one-pot sequential amine/NHC catalysis, led [3 + 2] cycloaddition afford ε,δ-bonded spiro[4.5]decanone structures 5. Alternatively, modifying standard amine catalysis by...
Here, we report a general approach to the synthesis of difluoroalkyl bicycloalkanes (CF2 -BCAs), as structural surrogates aryl ketones and ethers. The chemistry is driven by dihydrobenzoacridine photocatalyst, that engages in catalytic electron-donor acceptor (EDA) complex, or directly reduces fluorinated substrate. These two convergent manifolds lead generation R-CF2 radical, reacts with [1.1.1]- [3.1.1.]-propellane. method extremely general, extendable complex bioactive molecules (30...
Aminocatalysis is a well-established tool that enables the production of enantioenriched compounds under mild conditions. Its versatility underscored by its seamless integration with various synthetic approaches. While combination aminocatalysis metal catalysis, photochemistry, and stoichiometric oxidants has been extensively explored, synergy electrochemical activation remains largely unexplored. Herein, we present successful merger electrochemistry to perform SOMO-type transformations,...
To accelerate the discovery of novel metalloantibiotics we applied combinatorial synthesis to preparation 420 manganese tricarbonyl complexes.
The increasing popularity of four-member rings in drug discovery has prompted the synthetic chemistry community to advance and reinvent old strategies craft these structures. Recently, strain-release concept been used build complex architectures. However, although there are many for accessing small carbocyclic derivatives, synthesis azetidines remains underdeveloped. Here we report a photocatalytic radical strategy densely functionalized from azabicyclo[1.1.0]butanes. protocol operates with...
Two new 5-formyluracil thiosemicarbazone (H3ut) derivatives, Me-H3ut (1) and Me2-H3ut (2), were synthesized by reacting thiosemicarbazides, mono- dimethylated on the aminic nitrogen, with subsequently characterized. These ligands, treated copper chloride nitrate, afforded three complexes: [Cu(Me-H3ut)Cl2]·H2O (3), [Cu(Me2-H3ut)Cl2]·H2O (4), [Cu(Me-H3ut)(NO3)(OH2)2]NO3 (5). The crystal structures of these complexes have been determined single-crystal X-ray diffraction. In 3 4, a similar...
In this paper the syntheses of new pyridoxal thiosemicarbazone copper(II) and cobalt(III) complexes with nitroprusside as a counterion tests on antileukemic activity three these toward human cell lines U937 CEM are reported. Nitroprusside was chosen in order to test if its ability release NO can increase biological already shown by complexes. The compounds were characterized spectroscopic magnetic methods single-crystal X-ray diffraction.
Pt(IV) complexes are usually prepared by oxidation of the corresponding Pt(II) counterparts, typically using hydrogen peroxide or chlorine. A different way to synthesize asymmetrical compounds is oxidative chlorination counterparts with N-chlorosuccinimide. The reaction between cisplatin cis-[PtCl2(NH3)2], carboplatin, cis-[PtCl2(dach)] and cis-[Pt(cbdc)(dach)] (cbdc = cyclobutane-1,1′-dicarboxylato; dach cyclohexane-1R,2R-diamine) N-chlorosuccinimide in ethane-1,2-diol was optimized produce...
Twelve naphthochromenone photocatalysts (PCs) were synthesized on gram scale. They absorb across the UV/Vis range and feature an extremely wide redox window (up to 3.22 eV) that is accessible using simple visible light irradiation sources (CFL or LED). Their excited-state potentials, PC*/PC.- 1.65 V) PC.+ /PC* -1.77 V vs. SCE), are such these novel PCs can engage in both oxidative reductive quenching mechanisms with strong thermodynamic requirements. The potential of bimodal was benchmarked...
A scalable visible-light [2 + 2]-heterocycloaddition process allows the dearomatisation of indoles to complex biorelevant polycycles.
Copper complexes have shown promising anticancer properties, but they are often poorly soluble in aqueous solutions, thus limiting their possible medical developments and applications. We recently isolated some copper(II) with salicylaldehyde thiosemicarbazone ligands exhibiting remarkable nanomolar cytotoxic activity, vivo tests evidenced several difficulties related to poor solubility. To overcome these limitations increase solubility solution, herein we report the synthetic strategy that...