A5019534523- Metal-Catalyzed Oxygenation Mechanisms
- Cancer therapeutics and mechanisms
- Cardiac Imaging and Diagnostics
- Metal complexes synthesis and properties
- Hemoglobin structure and function
- Electrochemical Analysis and Applications
- DNA and Nucleic Acid Chemistry
- Protein Structure and Dynamics
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Electron Spin Resonance Studies
- Cardiovascular Function and Risk Factors
- Trace Elements in Health
- Lung Cancer Research Studies
- Bioactive Compounds and Antitumor Agents
- Environmental Toxicology and Ecotoxicology
- CO2 Reduction Techniques and Catalysts
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Photosynthetic Processes and Mechanisms
- Spectroscopy and Quantum Chemical Studies
- Antibiotics Pharmacokinetics and Efficacy
- Enzyme-mediated dye degradation
- Cardiac electrophysiology and arrhythmias
- Synthesis and biological activity
University of Rome Tor Vergata
2015-2024
Istituto Nazionale Biostrutture e Biosistemi
2011-2021
Universidade Federal de São Carlos
2019
Ospedale Castelfranco Veneto
2000-2018
Ospedale San Giacomo Apostolo
2002-2017
European University of Rome
2017
Azienda Sanitaria Locale Viterbo
2015
HTG Molecular Diagnostics (United States)
2014
National Research Council
1981-2012
Consortium GARR
2012
Through contemporary literature, the optimal strategy to manage coronary chronic total occlusions (CTOs) remains under debate. The aim of Italian Registry Chronic Total Occlusions (IRCTO) was provide data on prevalence, characteristics, and outcome CTO patients according management strategy. IRCTO is a prospective real world multicentre registry enrolling showing at least one CTO. Clinical angiographic were collected independently from therapeutic [optimal medical therapy (MT), percutaneous...
ObjectivesThis article aims to describe the various approaches in multivariable modelling of healthcare costs data and synthesize respective criticisms as proposed literature.
We demonstrate temperature-controlled encapsulation and release of the enzyme horseradish peroxidase using a preassembled covalently closed three-dimensional DNA cage structure as controllable device. The utilized was composed 12 double-stranded B-DNA helices that constituted edges structure. double stranded were interrupted by short single-stranded thymidine linkers constituting corners except for one, which four 32 nucleotide long stretches with sequence allowed them to fold into hairpin...
DNA offers excellent programming properties for the generation of nanometer-scaled polyhedral structures with a broad variety potential applications. Translation to biomedical applications requires improving stability in biological fluids, efficient and selective cell binding, and/or internalization assembled nanostructures. Here, we report an investigation on mechanism cellular uptake pristine nanocages cells expressing receptor "oxidized low-density lipoprotein receptor-1" (LOX-1),...
Intestinal dysbiosis has been widely documented in inflammatory bowel diseases (IBDs) and is thought to influence the onset perpetuation of gut inflammation. However, it remains unclear whether such bacterial changes rely part on modification an IBD-associated lifestyle (e.g., smoking physical activity) diet rich dairy products, cereals, meat vegetables). In this study, we investigated impact these habits, which defined as confounders covariates, modulation intestinal taxa abundance...
The reconstitution of Cu,Zn-superoxide dismutase from the copper-free protein by Cu(I).GSH complex was monitored by: (a) EPR and optical spectroscopy upon reoxidation enzyme-bound copper; (b) NMR following broadening resonances after addition Cu-free,Zn-superoxide dismutase; (c) Cu-free,Co(II) enzyme appearance isotropically shifted Cu(I), Co enzyme, found to be a very stable in presence oxygen more efficient copper donor than other low molecular weight Cu(II) complexes. In particular, 100%...
Background: Left ventricular systolic abnormalities have been reported in liver cirrhosis (LC). Diastolic function cirrhotics, on the contrary, does not seem to studied so far. Methods: was evaluated 42 cirrhotic patients and 16 controls by means of Doppler echocardiography. Results: Compared with controls, cirrhotics had increased left end-diastolic atrial volume, stroke late diastolic flow velocity (peak A) (71 ± 17 cm/sec versus 56 18; p < 0.01), time from onset mitral inflow early peak...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalcium ion independent membrane leakage induced by phospholipase-like myotoxinsS. Rufini, P. Cesaroni, A. Desideri, R. Farias, F. Gubensek, J. M. Gutierrez, Luly, Massoud, Morero, and Z. PedersenCite this: Biochemistry 1992, 31, 49, 12424–12430Publication Date (Print):December 15, 1992Publication History Published online1 May 2002Published inissue 15 December...
Abstract The topoisomerase-I (topo-I) inhibitor topotecan, derivative of camptothecin, is the only registered drug for relapsed small cell lung cancer (SCLC). histone deacetylase vorinostat has shown preclinical and clinical antitumor activities in hematologic malignancies solid tumors, including SCLC, recently been approved treatment cutaneous T-cell lymphomas. In this study, we analyzed effect combined with topotecan or camptothecin topo-I inhibitor-sensitive H209 inhibitor-resistant H526...
We present an attractive new system for the specific and sensitive detection of malaria-causing Plasmodium parasites. The relies on isothermal conversion single DNA cleavage-ligation events catalyzed specifically by enzyme topoisomerase I to micrometer-sized products detectable at single-molecule level. Combined with a droplet microfluidics lab-on-a-chip platform, this design allowed sensitive, specific, quantitative all human-malaria-causing species in drops unprocessed blood limit less...
The ability to control the charge-potential landscape at solid-liquid interfaces is pivotal engineer novel devices for applications in sensing, catalysis and energy conversion. isoelectric point (pI)/point of zero charge (pzc) graphene plays a key role number physico-chemical phenomena occurring graphene-liquid interface. Supported by theory, we present here methodology identify pI/pzc (functionalized) graphene, which also allows estimating nature extent ion adsorption. pI bare (as-prepared,...
The Trp53 gene is the most frequently mutated in all human cancers. Its protein product p53 a very powerful transcription factor that can activate different biochemical pathways and affect regulation of metabolism, senescence, DNA damage response, cell cycle death. understanding its function at molecular level could be pivotal relevance for therapy. Investigation long-range intra- interdomain communications tetramer–DNA complex was performed by means an atomistic model included...
Monolayer graphene field-effect sensors operating in liquid have been widely deployed for detecting a range of analyte species often under equilibrium conditions. Here we report on the real-time detection binding kinetics essential human enzyme, topoisomerase I interacting with substrate molecules (DNA probes) that are immobilized electrochemically to monolayer strips. By monitoring characteristics biosensor during enzyme–substrate interactions, able decipher surface constant cleavage...
DNA nanostructures of different sizes and forms are internalized in cells through the LOX-1 receptor with intracellular fate lifetime.
Over the past decades, Salmonella 4,[5],12:i:- has rapidly emerged and it is isolated with high frequency in swine food chain. Although many studies have documented epidemiological success of this serovar, few investigations tried to explain phenomenon from a genetic perspective. Here comparative whole-genome analysis 50 epidemiologically unrelated S. 4,[5],12:i:-, Italy 2010-2016 was performed, characterizing them terms elements potentially conferring resistance, tolerance persistence...