A5020678694- Metal complexes synthesis and properties
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Vanadium and Halogenation Chemistry
- Metal-Catalyzed Oxygenation Mechanisms
- Ferrocene Chemistry and Applications
- Magnetism in coordination complexes
- Organometallic Compounds Synthesis and Characterization
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- Crystal structures of chemical compounds
- Polyoxometalates: Synthesis and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Polysaccharides and Plant Cell Walls
- Protein Interaction Studies and Fluorescence Analysis
- Crystallography and molecular interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Click Chemistry and Applications
- Lipid Membrane Structure and Behavior
- Enzyme function and inhibition
- Drug Transport and Resistance Mechanisms
- Advanced Drug Delivery Systems
- Cell Adhesion Molecules Research
Universidad Nacional de La Plata
2016-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2016-2025
Hospital Universitario Fundación Jiménez Díaz
2024
Brooklyn College
2023
City University of New York
2023
Centro Científico Tecnológico - La Plata
2018-2022
Rede de Química e Tecnologia
2017-2021
Centro Científico Tecnológico - Tucumán
2017
Pontificia Universidad Católica de Chile
2002
Osteosarcoma cancers are becoming more common in children and young adults, existing treatments have low efficacy a very high mortality rate, making it pressing to search for new chemotherapies with selectivity index. Copper complexes shown promise the treatment of osteosarcoma. Here, we report synthesis, characterization, anticancer activity [Cu(N–N–Fur)(NO3)(H2O)] complex where N–N–Fur is (E)-N′-(2-hydroxy-3-methoxybenzylidene)furan-2-carbohydrazide. The was characterized via X-ray...
Flavonoids, a polyphenolic compound family, and the vanadium compounds have interesting biological, pharmacological, medicinal properties. We report herein antitumor actions of complex [VO(chrysin)2EtOH]2 (VOchrys) on MG-63 human osteosarcoma cell line. Oxovanadium(IV), chrysin VOchrys caused concentration-dependent inhibition viability. The was strongest antiproliferative agent (p < 0.05). Cytotoxicity genotoxicity studies also showed concentration effect. Reactive oxygen species (ROS)...
We report here the synthesis, crystal structure, characterization and anticancer activity of a copper(ii)-hydrazone complex, [Cu(MeBHoVa)(H2O)2](NO3) (for short, CuHL), against human breast cancer cells on monolayer (2D) spheroids/mammospheres (3D). The solid-state molecular structure complex has been determined by X-ray diffraction methods. conformational space was searched geometries were optimized both in gas phase including solvent effects computational methods based DFT. compound...
Vanadium is an ultratrace element present in higher plants, animals, algae, and bacteria. In recent years, vanadium complexes have been studied to be considered as a representative of new class nonplatinum metal anticancer drugs. Nevertheless, the study cell signaling pathways related compounds has scarcely reported on reviewed thus far; this information highly critical for identifying novel targets that play key role activity these compounds. Here, we perform review over cancer cells...
Abstract The purpose of this work was to screen the antitumor actions two metal organoruthenium-8-hydroxyquinolinato (Ru-hq) complexes find a potential novel agent for bone, lung and breast chemotherapies. We showed that ruthenium compounds (1 2) impaired cell viability human bone (MG-63), (A549) (MCF7) cancer cells with greater selectivity specificity than cisplatin. Besides, 1 2 decreased proliferation, migration invasion on monolayers at lower concentrations (2.5–10 μM). In addition, both...
[Cu(dmp)<sub>2</sub>(CH<sub>3</sub>CN)]<sup>2+</sup> can be reduced in acetonitrile containing water due to steric constraints of the ligands. Hydroxyl radicals are produced from oxidation. We take advantage this reaction evaluate anticancer activity complex.
Breast cancer is the most common in women, with a high incidence estimated to reach 2.3 million by 2030. Triple-Negative Cancer (TNBC) greatest invasive class of breast poor prognosis, due side-effects exerted chemotherapy used and low effectivity novel treatments. In this sense, copper compounds have shown be potentially effective as antitumor agents, attracting increasing interest alternatives usually employed platinum-derived drugs. Therefore, aim work identify differentially expressed...
Pd(<sc>ii</sc>) and P(<sc>ii</sc>) thiosemicarbazone complexes with high selectivity towards cancer cells a novel biological interaction profile.
Vanadium complexes were studied during recent years and considered as a representative of new class non-platinum metal antitumor agents in combination with their low toxicity. However, few challenges still remain the discovery molecular targets for these novel metal-based drugs. The study cell signaling pathways related to vanadium drugs, which is highly critical identifying specific that play an important role activity compounds, scarce. This research deals alterations intracellular...