A5059184386- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Crystal structures of chemical compounds
- Protein Interaction Studies and Fluorescence Analysis
- Synthesis and Biological Evaluation
- Magnetism in coordination complexes
- Ferrocene Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- DNA and Nucleic Acid Chemistry
- Click Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Synthesis and biological activity
- Organometallic Compounds Synthesis and Characterization
- Antibiotics Pharmacokinetics and Efficacy
- Inorganic and Organometallic Chemistry
- Drug Transport and Resistance Mechanisms
- Organometallic Complex Synthesis and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Cholinesterase and Neurodegenerative Diseases
- Chemical Reaction Mechanisms
- HIV/AIDS drug development and treatment
- Advanced biosensing and bioanalysis techniques
- Microbial Inactivation Methods
University of Ljubljana
2015-2024
EN-FIST Centre of Excellence (Slovenia)
2011-2015
Imperial College London
1998
Zinc complexes with the third-generation quinolone antibacterial drugs levofloxacin and sparfloxacin have been synthesized characterized. The deprotonated quinolones act as bidentate ligands coordinated to zinc ion through pyridone a carboxylato oxygen atom. crystal structures of [bis(aqua)bis(levofloxacinato)zinc(II)], 1, [bis(sparfloxacinato)(1,10-phenanthroline)zinc(II)], 3, determined by X-ray crystallography. biological activity has evaluated examining their ability bind calf-thymus DNA...
We report that 1-(2-picolyl)-1,2,3-triazole (click triazole) forms stable complexes with transition-metal ions in which the coordination involves triazole N2 nitrogen atom and pendant 2-picolyl group. This is exemplified by model compound 1-(2-picolyl)-4-phenyl-1H-1,2,3-triazole (L(x)) its of Pt(II), Pd(II), Cu(II), Ru(II), Ag(I). The was investigated experimentally theoretically. Ligand L(x) easily reacted at room temperature cis-[PtCl(2)(DMSO)(2)], [Pd(CH(3)CN)(4)](BF(4))(2), CuCl(2),...
Continuing the study of physicochemical and biological properties ruthenium-quinolone adducts, four novel complexes with general formula [Ru([9]aneS3)(dmso-κS)(quinolonato-κ2O,O)](PF6), containing quinolones levofloxacin (1), nalidixic acid (2), oxolinic (3), cinoxacin (4), were prepared characterized in solid state as well solution. Contrary to their organoruthenium analogues, these are generally relatively stable aqueous solution substitution dimethylsulfoxide (dmso) ligand is slow not...
Inspired by the emergence of resistance to currently available antifungal therapy and great potential metal complexes for treatment various diseases, we synthesized three new silver(I) containing clinically used azoles as ligands, [Ag(ecz)
With the aim of exploring anticancer properties organometallic compounds with bioactive ligands, Ru(arene) antibacterial quinolones nalidixic acid (2) and cinoxacin (3) were synthesized, their physicochemical compared to those chlorido(η(6)-p-cymene)(ofloxacinato-κ(2)O,O)ruthenium(II) (1). All undergo a rapid ligand exchange reaction from chlorido aqua species. 2 3 are significantly more stable than 1 minor conversion an unreactive [(cym)Ru(μ-OH)(3)Ru(cym)](+) species (cym = η(6)-p-cymene)....
An organometallic ruthenium complex of quinolone antibacterial agent ofloxacin, [(η6-p-cymene)RuCl(O,O-oflo)]·2.8H2O (1·2.8H2O), was isolated, and its crystal structure determined. In this “piano-stool” complex, is bidentately coordinated to the metal through ring carbonyl one carboxylic oxygen atoms. Interactions title with DNA were studied by spectroscopic methods [electronic, fluorescence, circular dichroism (CD)] atomic force microscopy (AFM). It established that electrostatic attraction...
The organoruthenium clioquinol complex induces copper-independent cell death in leukaemia cells by proteasome-independent inhibition of the NFκB signalling pathway.
Manganese(II) complexes with the non-steroidal anti-inflammatory drug tolfenamic acid (Htolf) nitrogen-donor heterocyclic ligands 1,10-phenanthroline (phen), pyridine (py), or 2,2′-bipyridylamine (bipyam) and/or oxygen-donor H2O N,N-dimethylformamide (DMF) have been synthesized and characterized. The crystal structures of [Mn(tolf-O)(tolf-O,O′)(phen)(H2O)], [Mn2(μ2-tolf-O,O′)2(tolf-O,O′)2(bipyam)2], [Mn2(μ2-H2O)(μ2-tolf-O,O′)2(tolf-O)2(py)4]·1.5MeOH·py, [Mn(μ2-tolf-O,O′)2(DMF)2]n determined...
The 1,4-disubstituted 1,2,3-triazole ligand prepared by click chemistry 1-(2-picolyl)-4-phenyl-1H-1,2,3-triazole (ppt) was investigated as novel chelating for Ru(II) complexes with potential antitumor activity. preparation and structural characterization, mainly NMR spectroscopy in solution X-Ray crystallography the solid state, of four new is reported: two isomeric Ru-dmso compounds, trans,cis-[RuCl2(dmso-S)2(ppt)] (1) cis,cis-[RuCl2(dmso-S)2(ppt)] (2), half-sandwich Ru-[9]aneS3...
With the aim of assessing whether ruthenium(II) compounds with meridional geometry might be utilized as potential antitumor agents, a series new, water-soluble, monofunctional complexes general formula mer-[Ru(L3)(N-N)X][Y]n (where L3 = 2,2′:6′,2″-terpyridine (tpy) or 4′-chloro-2,2′:6′,2″-terpyridine (Cl-tpy), N-N 1,2-diaminoethane (en), 1,2-diaminocyclohexane (dach), 2,2′-bipyridine (bpy); X Cl dmso-S; Y Cl, PF6, CF3SO3; n 1 2, depending on nature X) were synthesized. All fully...
A series of organoruthenium(II) chlorido complexes with fluorinated O,O-ligands [(η(6)-p-cymene)Ru(F3C-acac-Ar)Cl] (1a-6a) and their respective 1,3,5-triaza-7-phosphaadamantane (pta) derivatives [(η(6)-p-cymene)Ru(F3C-acac-Ar)pta]PF6 (1b-6b) were synthesized fully characterized in both solution solid state. All inactive against nonmalignant keratinocytes but displayed variable activity cancer cell models (ovarian, osteosarcoma). Compounds a ligand containing the 4-chlorophenyl substituent...