A5002853101- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Kruppel-like factors research
- Eosinophilic Disorders and Syndromes
- Multiple Myeloma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Complement system in diseases
- Ferrocene Chemistry and Applications
- RNA Interference and Gene Delivery
- COVID-19 and healthcare impacts
- Click Chemistry and Applications
- Peptidase Inhibition and Analysis
- Geological and Geochemical Analysis
- DNA and Nucleic Acid Chemistry
- Peripheral Neuropathies and Disorders
- Geochemistry and Geologic Mapping
- Amyloidosis: Diagnosis, Treatment, Outcomes
First Pavlov State Medical University of St. Petersburg
2016-2025
Singapore General Hospital
2023
Duke-NUS Medical School
2023
Versiti Blood Center of Wisconsin
2023
Moffitt Cancer Center
2023
Premier Research Group
2023
Health Outcomes Solutions (United States)
2023
Mayo Clinic
2023
WinnMed
2023
University of Zagreb
2023
Abstract JAK1/2 inhibitor ruxolitinib (RUX) is approved in patients with myelofibrosis but the impact of pretreatment RUX on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) remains to be determined. We evaluated 551 who received HSCT without ( n = 274) or 277) pretreatment. The overall leukocyte engraftment day 45 was 92% and significantly higher responsive than those had no lost response (94% vs. 85%, p 0.05). 1-year non-relapse mortality 22% significant difference...
An organometallic ruthenium complex of quinolone antibacterial agent ofloxacin, [(η6-p-cymene)RuCl(O,O-oflo)]·2.8H2O (1·2.8H2O), was isolated, and its crystal structure determined. In this “piano-stool” complex, is bidentately coordinated to the metal through ring carbonyl one carboxylic oxygen atoms. Interactions title with DNA were studied by spectroscopic methods [electronic, fluorescence, circular dichroism (CD)] atomic force microscopy (AFM). It established that electrostatic attraction...
The active use of telemedicine technologies is relevant both in foreign and domestic medicine. Objective: to assess the demand for services outpatient practice using example polyclinics Krasnogorsk Hospital Moscow Region. Materials. Analysis data from state information system “Unified Medical Information Analytical System Region” State Budgetary Healthcare Institution Region “Krasnogorsk Hospital”, as well medical organizations providing primary health care Telemedicine consultations...
Background Hematopoietic stem cell transplantation (HSCT) offers a potential cure for various hematologic malignancies and non-malignant disorders but is often accompanied by severe complications, one of the most challenging being transplant-associated thrombotic microangiopathy (TA-TMA). Eculizumab, complement inhibitor, has emerged as an effective therapeutic option TA-TMA. Methods This single-center retrospective study was conducted at Pavlov University, St. Petersburg, to evaluate...
We report on the interaction of cationic azobenzene-containing surfactant with DNA investigated by absorption and fluorescence spectroscopy, dynamic light scattering, atomic force microscopy. The properties can be controlled reversible switching azobenzene unit, incorporated into tail, between a hydrophobic trans (visible irradiation) hydrophilic cis (UV configuration. influence trans-cis isomerization compaction process molecules role both isomers in formation colloidal stability...
<b><i>Introduction:</i></b> This prospective study evaluated a calcineurin inhibitor-free graft-versus-host disease (GVHD) prophylaxis regimen of ruxolitinib in combination with post-transplant cyclophosphamide (PTCy). <b><i>Patents and Methods:</i></b> Twenty patients primary or secondary myelofibrosis were prospectively enrolled. Reduced intensity conditioning was performed, followed by allogeneic stem cell transplantation from related...
The development of National clinical guidelines on diagnosis and treatment Ph-negative myeloproliferative neoplasms comes in response to the need standardize approach treatment. availability can facilitate choice adequate strategy, provides practicing physicians with exhaustive up-to-date information advantages shortcomings different methods as well lets health professionals better assess expected extents required by patients. In 2013 a working group was formed develop formulate neoplasms....
This article is the 4th edition of recommendations for diagnosis and treatment chronic myeloid leukemia. The group authors reviewed discussed relevant new publications, included significant remarks comments experts. Particular attention was paid to control risk factors development arterial vascular events their prevention, adverse effects longterm therapy with tyrosine kinase inhibitors, which were being increasingly reported in recent years.
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is the only treatment option with curative potential in patients myelofibrosis (MF). The aim of our study was to evaluate safety splenectomy before alloHSCT MF who failed achieve significant spleen response after ruxolitinib therapy.Splenectomy performed 12 for myelofibrosis-primary (6 patients), post-polycythemia vera (3 patients). or postessential thrombocythemia patients) between 2016 and 2018. were prospectively included if...
Summary Allogeneic haematopoietic cell transplantation (allo‐HCT) remains an option for tyrosine kinase inhibitor‐resistant chronic myeloid leukaemia (CML) in first phase (CP1) and high‐risk patients with advanced disease phases. In this European Society Blood Marrow Transplantation (EBMT) registry‐based study of 1686 CML undergoing allo‐HCT between 2012 2019, outcomes were evaluated according to donor type, particularly focusing on mismatched related donors (MMRDs). Median age at was 46...
Background . The T315I mutation in BCR::ABL1 kinase domain determines the resistance of leukemia cells to tyrosine inhibitors (TKIs) – imatinib and secondgeneration TKIs patients with chronic myeloid (CML). impact new T315I-targeted approaches on treatment outcomes is being actively studied. Aim To evaluate clinical characteristics therapy chronic-phase CML practice. An additional objective overall survival (OS) by considering provided. Materials methods non-interventional retrospective...
Chronic myeloproliferative neoplasms are characterized by clonal hematopoiesis and persistent inflammatory reaction. In this study, the clinical significance prognostic impact of several markers were evaluated in patients with BCR/ABL-negative malignancies.Serum levels interleukin-8 (IL-8) lymphoid-associated activation - soluble interleukin-2 receptor (sIL-2R) immunoglobulin-free light chains (FLC) primary myelofibrosis (MF), post-polycythemia vera MF, post-essential thrombocythemia...
Immune checkpoint inhibitors (ICIs) are rather efficient in classical Hodgkin's lymphoma (cHL).Pembrolizumab (pembro) is approved children and demonstrates high response rates with acceptable toxicity.The role of nivolumab (nivo) pediatric cHL only to be elucidated.The aim the presented study was assess safety efficiency nivo this age group relapsed or refractory (R-R) cHL.Twenty-one heavily pre-treated patients 9-18 years old received nivo-based therapy.Overall registered 86% (complete -57%...
In this single-center analysis, we evaluated the trends in 5185 hematopoietic cell transplantations performed between 1990 and 2022. The study group comprised 3237 allogeneic (alloHCT) 1948 autologous (autoHCT) transplantations. multivariate there was an improvement event-free-survival (EFS) after autoHCT (HR 0.6, 95% CI 0.4-0.7, p < 0.0001) due to reduced cumulative incidence of relapse last five years (56% 2010-2014 vs. 38% 2015-2022). An EFS alloHCT over time observed 0.33, 0.23-0.48,...
Aim. Using strict criteria, to assess incidence, pretransplant risk factors, and outcomes of severe "poor graft function" (sPGF), following allogeneic hematopoietic stem cell transplantation (allo-HSCT) in adults. Materials & Methods. The study included 710 adult patients (median age was 31 years, range 18-70 years; 55 % male 45 female patients) with different hematological diseases documented transplant engraftment after allo-HSCT from matched sibling (20 %), unrelated (67 %)...
Posttransplant cytopenias due to poor graft function (PGF) are a severe complication of allogeneic transplantation hematopoietic stem cells (allo-HSCT).Conventional therapeutic options for limited infusions CD34-selected cells.However, having shown encouraging results in idiopathic thrombocytopenia and aplastic anemia, thrombopoietin receptor agonists (TPO-RA) romiplostim eltrombopag might be possible alternative treatment strategy PGF after allo-HSCT.Current study aims summarize...
Transplant-associated thrombotic microangiopathy (TA-TMA) is a specific complication of allogeneic hematopoietic cell transplantation with multifactorial etiology. There little evidence published regarding the efficacy and factors influencing outcome substitution calcineurin inhibitors (CNIs) other agentsas widely accepted practice in this disorder; however, there are limited data on options for immunosuppression manipulation (ISM). In our study, we retrospectively analyzed outcomes 45...
A number of sequencing studies identified the prognostic impact somatic mutations in myelodysplastic syndrome (MDS). However majority them focused on methylation regulation, apoptosis and proliferation genes. Despite experimental published role micro-RNA processing checkpoint genes development MDS, clinical data about mutational landscape these is limited. We performed a pilot study which evaluated burden their association with common MDS mutations. High prevalence was observed studied: 54%...
Classical Ph-negative myeloproliferative neoplasms (MPN) constitute a group of diseases including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Over the past decade, approaches to understanding MPN pathogenesis therapy have considerably changed. At same time, etiological factors pathophysiological mechanisms disease progress are being thoroughly studied. The improvement diagnosis methods new can reduce complications mortality risks. review outlines current methods,...
Primary immunodefi ciency syndromes are relatively rare medical conditions that oft en misdiagnosed because of unspecifi c clinical presentation mimics other more common diseases.Incidence combined variable (CVID) is ca. 1 case per 30.000European population.Usually, a delay several years observed between onset and diagnosis.CVID the most frequent primary aft er 4 life.Th e key symptom to establish disorder hypogammaglobulinemia.Th aim this article demonstrate current trends in diagnostics...
Background. The national observational program MPN-QoL-2020 was focused on quality of life (QoL) and symptoms in patients with classical Ph-negative myeloproliferative neoplasms (MPNs) the Russian Federation, as well perception disease treatment from patient's physician's perspective. Aim. To evaluate QoL different MPNs using new standardized questionnaires, to assess most common their impact myelofibrosis (MF), polycythemia vera (PV) essential throm-bocythemia (ET), characterize concerns...
The role of prophylactic TKIs after allogeneic stem cell transplantation in Ph-positive acute lymphoblastic leukemia (ALL) remains controversial.We performed a retrospective study 106 adult patients subjected to hematopoietic (allo-HSCT) from matched related donors (MRD, 26%), unrelated (MUD/MMUD, 60%), and haploidentical (14%) complete remission (CR1, 59%), CR2 (14%), advanced disease (27%).Among them, 60 (57%), received 1 st -or 2 nd -generation as prophylaxis allo-HSCT.In multivariate...