A5081839235- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Chronic Myeloid Leukemia Treatments
- Virus-based gene therapy research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Spondyloarthritis Studies and Treatments
- Polyomavirus and related diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Viral Infectious Diseases and Gene Expression in Insects
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Transplantation: Methods and Outcomes
- Liver Diseases and Immunity
- Histone Deacetylase Inhibitors Research
Krankenhaus der Elisabethinen
2016-2024
Johannes Kepler University of Linz
2021-2024
Paracelsus Medical University
2011-2015
Paracelsus Medizinische Privatuniversität
2013
Innsbruck Medical University
2006-2012
University Hospital Innsbruck
2000-2012
Unfallkrankenhaus Salzburg
2012
Universität Innsbruck
2001
Universität Hamburg
1997-2000
University Medical Center Hamburg-Eppendorf
1997-2000
The broad-spectrum triazole posaconazole showed promising results in preventing invasive fungal infections (IFIs) high-risk patients. Concerns rise over the relevance of breakthrough IFIs (bIFIs) and emergence azole-resistant strains. current retrospective analysis was undertaken to evaluate incidence bIFIs study colonization resistance following exposure.Ninety-five patients who underwent 202 courses primary antifungal prophylaxis with 200 mg three times daily during neutropenia after...
Abstract JAK1/2 inhibitor ruxolitinib (RUX) is approved in patients with myelofibrosis but the impact of pretreatment RUX on outcome after allogeneic hematopoietic stem cell transplantation (HSCT) remains to be determined. We evaluated 551 who received HSCT without ( n = 274) or 277) pretreatment. The overall leukocyte engraftment day 45 was 92% and significantly higher responsive than those had no lost response (94% vs. 85%, p 0.05). 1-year non-relapse mortality 22% significant difference...
Serum levels of vascular endothelial growth factor (VEGF-S) have been reported to correlate with tumor stage and prognosis in various human malignancies. The source soluble VEGF peripheral blood remains obscure. We therefore measured the concentration immunoreactive 241 serum samples 61 plasma (VEGF-P) from 20 subjects undergoing myeloablative chemotherapy 3 normal platelet donors. A significant correlation between count (PC) VEGF-S (r = 0.86) but not VEGF-P was found. were 58.43 +/- 42.50...
Circulating CD8(+) CD28(-) T cells were found to be expanded more in patients with ankylosing spondylitis than an age-matched healthy population (41.2 +/- 17.7% versus 18.6 7.6%). The level of CD8(+)CD28(-) was dependent on the disease status, but independent age. Most produced perforin after stimulation vitro, contrast their CD8(+)CD28(+) counterparts. From clinical perspective, percentage cytotoxic reflected a severe course disease, as it correlated distinct movement restrictions, well...
FOXP3+ regulatory T-cells (Treg) are important regulators of allo-reactivity and may therefore represent an predictor for the risk graft versus-host disease (GVHD) after allogeneic stem cell transplantation.To determine clinical significance Treg-content in grafts, we analyzed 58 human leukocyte antigen (HLA)-identical sibling donors (34 patients received myeloablative 24 reduced intense conditioning regimens) correlated Treg frequency with outcome transplantation (SCT).A mean value 9.1 x...
To define the role of quantitative graft composition and donor killer-cell immunoglobulin-like receptor (KIR) genotype in clinical outcome following unmanipulated peripheral blood stem cell transplantation (PBSCT) from human leucocyte antigen (HLA)-identical siblings, 43 consecutive transplants for haematological malignancies were analysed retrospectively. Twenty-four patients underwent myeloablative conditioning 19 received busulphan/fludarabine-based reduced intensity (RIC). In with acute...
T-prolymphocytic leukemia (T-PLL) is a rare lymphoid neoplasm with particularly poor prognosis. B-prolymphocytic (B-PLL), although no longer recognized as distinct entity by the World Health Organization (WHO), comprises conditions unfavorable outcome well. Both diseases most frequently affect patients in 7th decade of their lives. Allogeneic hematopoietic stem cell transplantation (alloHSCT) significantly improves outcomes for selected PLL cases shown several, mostly retrospective,...
Abstract Background Human metapneumovirus (hMPV) epidemiology, clinical characteristics and risk factors for poor outcome after allogeneic stem cell transplantation (allo-HCT) remain a poorly investigated area. Methods This retrospective multicenter cohort study examined the characteristics, outcomes associated with human infections in recipients of allo-HCT. Results We included 428 allo-HCT who developed 438 hMPV infection episodes between January 2012 2019. Most were adults (93%)....
Human hematopoietic stem cells remain one of the most promising target for gene therapeutic approaches to treat malignant and nonmalignant diseases. To rapidly characterize transduced isolate these from residual nontransduced, but biologically equivalent, cells, we have used a Moloney murine leukemia virus (Mo-MuLV)-based retroviral vector containing intracytoplasmatically truncated human low-affinity nerve growth factor receptor (ΔLNGFR) cDNA as marker gene. Supernatant transduction CD34+...
Elevated serum ferritin levels occur due to iron overload or during inflammation and macrophage activation. A correlation of high with increased mortality after alloSCT has been suggested by several retrospective analyses as well two smaller prospective studies. This multicentric study aimed the association before start conditioning outcome. Patients acute leukaemia, lymphoma MDS receiving a matched sibling for first time were considered inclusion, regardless conditioning. comparison...
We have previously shown that allogeneic bone marrow transplantation (BMT) with cryopreserved donor cells can be used without prolonging the engraftment time or interfering reconstitution of haemopoiesis. In this report we extend our initial observations first 40 patients who underwent from related donors for haematological malignancies, including long‐term follow‐up data reported patients. The outcome these was compared BMT recipients receiving fresh (historic control group). Time until all...
SummaryThe full spectrum of invasive Haemophilus influenzae disease has not been documented previously in Africa. This 1-year prospective study was designed to determine the epidemiology Cape Town children. During this period, 142 children with were hospitalized; 85 (59.9%) presented meningitis, 35 (24.6%) pneumonia and 22 (15.5%) other diseases. No cases epiglottitis seen. Sixty per cent male 40% female. The median age 9 months, a range 1–144 65.5% aged < 12 months. Neurological dysfunction...
Despite effective preemptive and prophylactic therapeutic strategies, cytomegalovirus (CMV) seropositivity of either recipient and/or donor still remains an important parameter for outcome even after reduced-intensity allogeneic stem cell transplantation (SCT). Whether CMV the might have impact on leukemic relapse is unknown.Between June 1999 February 2004 48 patients ineligible conventional allotransplantation underwent transplants at our institution. Twenty-seven (56%) had a...
Allogeneic hematopoietic stem cell transplantation is frequently complicated by syndromes characterized a disruption of the endothelial integrity such as graft-versus-host disease or liver toxicity. Vascular growth factor and activin-A, member transforming beta (TGF-β) superfamily, are important for tissue repair. We retrospectively measured endogenous vascular activin-A serum levels in 70 patients following allogeneic transplantation. were significantly decreased within first 2 weeks after...