A5086577784- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Antifungal resistance and susceptibility
- HIV/AIDS drug development and treatment
- Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Cancer Treatment and Pharmacology
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- Protein Degradation and Inhibitors
- Infectious Diseases and Mycology
- Viral-associated cancers and disorders
- Histone Deacetylase Inhibitors Research
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Mycobacterium research and diagnosis
Azienda Sanitaria Ospedaliera S.Croce e Carle Cuneo
2016-2025
Carle Foundation Hospital
2007-2024
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2020
University of Milan
2020
University of Modena and Reggio Emilia
2015
Gruppo Italiano per il Trapianto di Midollo Osseo
2004
University of Genoa
1998-2001
Ospedale Policlinico San Martino
1997-2000
Istituto di Ematologia di Bologna
1997
In this trial of the treatment newly diagnosed multiple myeloma, we compared a protocol that entailed hematopoietic stem-cell autograft followed by an allograft from HLA-identical sibling with tandem autografts.We enrolled 162 consecutive patients myeloma who were 65 years age or younger and had at least one sibling. All initially treated vincristine, doxorubicin, dexamethasone, melphalan autologous rescue. Patients then received nonmyeloablative total-body irradiation stem cells without two...
Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that inclusion antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia would result significant reduction chronic GVHD 2 years peripheral-blood transplantation from an HLA-identical sibling.We conducted prospective, multicenter, open-label, randomized phase 3 study ATG...
Epidemiologic investigation of invasive fungal diseases (IFDs) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) may be useful to identify subpopulations who might benefit from targeted treatment strategies. The Gruppo Italiano Trapianto Midollo Osseo (GITMO) prospectively registered data on 1858 consecutive patients undergoing allo-HSCT between 2008 and 2010. Logistic regression analysis was performed risk factors for proven/probable IFD (PP-IFD) during the early (days 0...
The number of long‐term survivors after allogeneic bone marrow transplantation (BMT) has been increasing over the past years, and quality life (QOL) become an important end‐point. We studied 244 patients undergoing BMT to identify factors events influencing psychosocial outcome. Patients enrolled received Psychosocial Adjustment Illness Scale (PAIS) questionnaire assessing psychological social adjustment chronic illness or its sequelae. Eighty‐two per cent had a haematological disease....
Positive Platelia Aspergillus test results were observed in consecutive serum samples from an immunocompromised host during amoxicillin-clavulanic acid treatment, and a correlation between plasmatic amoxicillin concentration galactomannan optical density index was observed. Amoxicillin-clavulanic vials tested positive for but negative DNA.
Highlights•Favorable outcome of a modified PT-CY regimen, with cyclosporin given before PT-CY.•It is associated very low rate relapse in remission patients.•We have seen incidence GVHD, despite the use cyclosporine PT-CY.•These results may not translate automatically to unmanipulated peripheral blood.AbstractWe report post-transplant cyclophosphamide (PT-CY) for haploidentical marrow transplants, 150 patients acute myeloid leukemia (AML). All received myeloablative A (CsA) on day 0,...
Despite effective treatments, cytomegalovirus (CMV) continues to have a significant impact on morbidity and mortality in allogeneic stem cell transplant (allo-SCT) recipients. This multicenter, retrospective, cohort study aimed evaluate the reproducibility of safety efficacy commercially available letermovir for CMV prophylaxis real-world setting. Endpoints were rates clinically infection (CSCI), defined as disease or viremia reactivation within day +100-+168. 204 adult CMV-seropositive...
Post-transplant high-dose cyclophosphamide (PTCy) is effective in overcoming the negative impact of HLA disparity haploidentical setting. In light these results, we investigated efficacy and safety PTCy, with a calcineurine inhibitor mycophenolate mofetil, improving clinical outcomes haematopoietic cell transplantation (HCT) from mismatched unrelated donor (MMUD) patients acute myeloid malignancies by reducing aGvHD incidence severity. A prospective single arm, phase II study (PHYLOS -...
Antibodies directed against donor-specific HLA allele(s)/antigen(s) (DSAs) represent a known risk factor for hematopoietic stem cell transplantation (HSCT) engraftment. Still, the overall management needs to be standardized. GITMO and AIBT ran survey on DSAs in Italian Transplant Programs including mismatched HSCT performed between January 2014 June 2017. One-thousand-thirty-three patients were proposed study, 804 evaluable. Overall, 355 (44%) screened: 91/355 (25.6%) showed anti-HLA...
Abstract: This report describes the diagnosis and management of a 16‐year‐old boy who developed neurological signs symptoms suggestive cerebral aspergillosis following haploidentical bone marrow transplant. A new sandwich enzyme‐linked immunosorbent assay (ELISA) for detection Aspergillus galactomannan circulating antigens (Platelia , Sanofi Diagnostic Pasteur, France) was used on serum cerebrospinal fluid to obtain presumptive monitor course disease. Having failed conventional therapy with...
Infections are a major cause of morbidity and mortality during neutropenia after hematopoietic stem cell transplantation (HSCT). The use low-microbial protective diet (PD) in the peritransplantation period is standard care, although its efficacy has never been tested prospectively. We conducted multicenter, randomized, noninferiority trial, enrolling all consecutive adult patients undergoing high-dose induction chemotherapy or HSCT with objective to compare nonrestrictive (NRD) vs PD....
We report two cases of Acremonium fungemia with proven involvement the skin and probably lung in patients who were both undergoing chemotherapy, one for mantle cell lymphoma other acute lymphoblastic leukemia. Both failed amphotericin B deoxycholate treatment successfully treated voriconazole very mild toxicity.