A5003517613- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- Oral health in cancer treatment
- Polyomavirus and related diseases
- Multiple Myeloma Research and Treatments
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Blood groups and transfusion
- Fungal Infections and Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pancreatic function and diabetes
- Hematological disorders and diagnostics
- Mesenchymal stem cell research
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- Peripheral Neuropathies and Disorders
Instytut Hematologii i Transfuzjologi
2015-2024
Medical University of Warsaw
2010-2020
Warsaw University of Technology
2020
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Institute of Haematology and Blood Transfusion
2015
Institute for Transfusion Medicine
2015
Gdańsk Medical University
1994-2006
Wojskowy Instytut Medyczny
1995
Gut colonization by antibiotic-resistant bacteria may underlie hard-to-treat systemic infections. There is also accumulating evidence on the immunomodulatory function of gut microbiota after allogeneic stem cell transplantation (alloSCT) and its impact graft-versus-host disease (GVHD). We investigated epidemiology clinical alloSCT retrospectively analyzed data 107 alloSCTs performed at a single transplant center. Pretransplant microbiology screening identified in 31% cases. Colonization had...
POEMS syndrome is a rare para-neoplastic secondary to plasma cell dyscrasia. Effective treatment can control the disease-related symptom complex. We describe clinical outcome of autologous stem transplantation for patients with syndrome, determining impact patient- and disease-specific factors on prognosis. One hundred twenty-seven underwent an between 1997–2010 median age 50 years (range 26–69 years). Median time from diagnosis was 7.5 months 32% receiving more than 12 diagnosis....
Incidence and outcome of microbiologically documented bacterial/viral infections invasive fungal disease (IFD) in children adults after hematopoietic cell transplantation (HCT) were compared 650 3200 multicenter cross-sectional nationwide study. Infections diagnosed 60.8% 35.0% adults, including respectively 69.1% 63.5% allo-HCT, 33.1% 20.8% auto-HCT patients. The incidence bacterial was higher (36.0% vs 27.6%; p < 0.0001). with Gram-negative bacteria more frequent than Gram-positives (64.6%...
Abstract: Between January 1991 and December 1997, 103 patients, 97 with typical hairy cell leukemia (HCL) 6 HCL‐variant (HCL‐V) were treated 2‐chlorodeoxyadenosine (2‐CdA) given as 2‐h infusion for 5 consecutive d at a daily dose 0.12 mg/kg. To our knowledge this is the largest cohort of HCL patients type regimen. Median follow‐up amounted to 36 months. Fifty‐six newly diagnosed 41 relapsed after previous treatment. Splenectomy first‐line therapy was performed in 23 18 remaining received...
2‐Chlorodeoxyadenosine (2‐CdA) is a new purine analogue active in indolent lymphoid malignancies. In this retrospective study 22 patients with Waldenström's macroglobulinemia (MW) were treated 2‐CdA given 2‐h intravenous infusions. Nine of them untreated and 13 relapsed or refractory to previous therapeutic modalities chlorambucil/prednisone (11 patients) COP (2 patients). The 1–11 (median 4) courses at the dose 0.14 mg/kg daily infusion for 5 consecutive days. repeated every 28–35 d. If...
Some cancers treated with allogeneic hematopoietic stem cell transplantation (HSCT) are sensitive to natural killer (NK) reactivity. NK function depends on activating and inhibitory receptors is modified by education/licensing effect mediated coexpression of killer-cell immunoglobulin-like receptor (KIR) its corresponding HLA I ligand. We assessed KIR (aKIR)-based I-dependent education capacity in donor NKs 285 patients hematological malignancies after HSCT from unrelated donors. found...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the sole potential cure for paroxysmal nocturnal hemoglobinuria (PNH); however, data on its utility in PNH are limited. This retrospective analysis of patients with who underwent allo-HSCT 11 Polish centers between 2002 and 2016 comprised 78 PHN, including 27 classic (cPNH) 51 bone marrow failure-associated (BMF/PNH). The cohort was 59% male, a median age 29 years (range, 12 to 65 years). There history thrombosis 12% hemolysis...
Core binding factor acute myeloid leukemia (AML) comprises two subtypes with distinct cytogenetic abnormalities of either t(8;21)(q22;q22) or inv(16)(p13q22)/t(16;16)(p13;q22). Since long-term response to chemotherapy in these leukemias is relatively good, allogeneic hematopoietic stem cell transplantation considered patients who relapse and achieve second complete remission. To evaluate the outcomes this indication, we studied 631 reported European Society for Blood Marrow Transplantation...
Abstract The current incidence, diagnostic policy, management, and outcome of VOD/SOS at EBMT centers were studied. All that had performed allogeneic HSCTs in adult patients within one defined year invited to the study. Seventy-one participated with a total 2886 transplantations 93 cases 2018. cumulative incidence day 21 was 1.8% 100 2.4%. Of 67 detailed data, 52 classical 15 (22%) late onset (>day 21). According criteria, 65/67 least two risk factors. severity grades were: mild 0,...
Among cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), some are sensitive to natural killer (NK) cell reactivity, described as the "missing self" recognition effect. However, this model disregarded NK licensing effect, which highly increases reactivity against tumor and is dependent on coexpression of inhibitory immunoglobulin-like receptor (iKIR) its corresponding HLA Class I ligand. We assessed clinical data, donor iKIR genotyping in 283 patients myelo-...
Implementation of evidence-based guidelines for the treatment invasive fungal disease (IFD) requires collaboration among numerous clinical and laboratory services, as partners in patient care. The multidisciplinary team (MDT) approach has emerged a way providing comprehensive medical care by bringing together professionals from wide range disciplines coordinated effective manner. Here, we propose an MDT model IFD management aimed at facilitating communication consultants, adherence to...