A5086798033- Pharmacogenetics and Drug Metabolism
- Autoimmune Bullous Skin Diseases
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Hematopoietic Stem Cell Transplantation
- Systemic Sclerosis and Related Diseases
- Glutathione Transferases and Polymorphisms
- Acute Lymphoblastic Leukemia research
- Drug Transport and Resistance Mechanisms
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Urticaria and Related Conditions
- Inflammatory mediators and NSAID effects
- Genomics, phytochemicals, and oxidative stress
- Immunotherapy and Immune Responses
- Biomarkers in Disease Mechanisms
- Skin and Cellular Biology Research
- Immunotoxicology and immune responses
- Acute Myeloid Leukemia Research
- Endometriosis Research and Treatment
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Powdery Mildew Fungal Diseases
- Prion Diseases and Protein Misfolding
- European Law and Migration
Medical University of Lodz
2013-2024
Poznan University of Medical Sciences
2013-2022
Centrum Onkologii
2015
Nofer Institute of Occupational Medicine
2004-2008
Some cancers treated with allogeneic hematopoietic stem cell transplantation (HSCT) are sensitive to natural killer (NK) reactivity. NK function depends on activating and inhibitory receptors is modified by education/licensing effect mediated coexpression of killer-cell immunoglobulin-like receptor (KIR) its corresponding HLA I ligand. We assessed KIR (aKIR)-based I-dependent education capacity in donor NKs 285 patients hematological malignancies after HSCT from unrelated donors. found...
Among cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), some are sensitive to natural killer (NK) cell reactivity, described as the "missing self" recognition effect. However, this model disregarded NK licensing effect, which highly increases reactivity against tumor and is dependent on coexpression of inhibitory immunoglobulin-like receptor (iKIR) its corresponding HLA Class I ligand. We assessed clinical data, donor iKIR genotyping in 283 patients myelo-...
Abstract Background Studies concerning the etiopathogenesis of numerous diseases emphasize involvement genetically determined impairments xenobiotic metabolism. Nowadays, more attention has been drawn to role cytochrome P450 and its isoenzymes in course dermatological diseases, including pemphigoid, most frequently occurring autoimmune bullous disease, whose not completely elucidated. Aim The aim study was find out whether there any relationship between CYP 2D6 gene polymorphism development...
Bullous pemphigoid (BP) constitutes the most prevalent disease in group of bullous dermatoses with autoimmune background. Some authors suggest that certain cytokines (IL-2, IFN-γ) may be transported by P-glycoprotein (P-gp), product ABCB1 gene. polymorphism might affect not only effectiveness treatment drugs are P-gp substrates but also contribute to development diseases, including BP. In present work, we resolved conduct a haplotype analysis patients BP and answer question whether any...
Myeloid sarcoma (MS) is an extramedullary malignant tumor composed of immature myeloid cells. It occurs in patients with acute leukemia (AML), myelodysplastic syndrome (MDS), or chronic (CML). MS may coincide disease diagnosis precede bone marrow involvement by months even years; it can also represent the manifestation a relapse (1, 2).The aim this study to describe clinical characteristics children diagnosed Poland as well analyze diagnostic methods, treatment, and outcomes including...
Systemic lupus erythematosus (SLE) is a complex, multifactor autoimmune disease. The studies on aetiopathogenesis of diseases focus the impact genetically conditioned impairment xenobiotic metabolism may exert. knowledge oxidation polymorphism in course SLE be helpful choosing more efficient and safer therapy. We determined whether there was an association between susceptibility to particularly CYP2D6 genotypes.The study carried out 60 patients with 129 healthy volunteers all subjects were...
Despite the fact that choice of donors and number sources hematopoietic stem cells have increased, a sibling remains preferred donor for allogeneic cell transplantation (HSCT). Transplant donation between siblings is unique life experience may an impact on their future relationship. The aim study was to quantitatively measure quality (QoL) in patients who underwent transplant describe relationship recipient after HSCT. We identified invited 82 adults aged 18.0 38.7 years (median, 23.6) HSCT...
Inflammatory bowel disease (IBD) consists of ulcerative colitis (UC) and Crohn’s (CD), which are complex genetic disorders resulting from the interplay between several environmental risk factors. The arylamine N-acetyltransferase 2 (NAT2) enzyme detoxifies a wide spectrum naturally occurring xenobiotics including carcinogens drugs. Acetylation catalyzed by NAT2 is an important process in metabolic activation arylamines to electrophilic intermediates that initiate carcinogenesis. aim our...
AMA Rychlik-Sych M, Baranska Waszczykowska E, Torzecka J, Zebrowska A, Skretkowicz J. Original paperGenetic polymorphisms of CYP2D6 oxidation in patients with autoimmune bullous diseases. Advances Dermatology and Allergology/Postępy Dermatologii i Alergologii. 2013;30(4):211-217. doi:10.5114/pdia.2013.37030. APA Rychlik-Sych, M., Baranska, Waszczykowska, E., Torzecka, J., Zebrowska, A., & Skretkowicz, (2013). Alergologii, 30(4), 211-217. https://doi.org/10.5114/pdia.2013.37030 Chicago...
Human organism is constantly exposed to harmful exogenous factors (xenobiotics) including drugs and carcinogenic compounds that can induce development of a large number diseases. The processes biotransformation in the are multidirectional xenobiotics be transformed into active or inactive metabolites via oxidative route. knowledge oxidation polymorphism course systemic lupus erythematosus sclerosis may helpful choosing more efficient safer therapy, particularly case disease involving various...
Summary Background and objectives Polymorphisms in the P‐glycoprotein‐encoding ABCB1 gene may affect intracellular concentration of xenobiotics, thus contribute to development autoimmune diseases, including bullous pemphigoid (BP). The objective present study was investigate whether there is an association between C3435T G2677T/A polymorphisms risk BP a Polish population. Patients methods included 71 patients with 156 healthy volunteers. Determination polymorphism carried out using PCR‐RFLP;...
We performed a cross-sectional study involving workers from four European countries in which exposure to pesticides and immune parameters were evaluated over short period of time. The total population consisted 238 occupationally exposed 198 nonoccupationally workers. showed that pesticide at levels encountered by under different conditions Europe did not affect the ability system respond vaccination. could, however, identify individuals within group who genetically characterized 2.2 IL-1α...
Abstract Aim It is commonly assumed that a genetically determined polymorphism of xenobiotic biotransformation plays particular role in the development such disease entities which chemical compounds and environmental pollutants are relevant etiologic factors. Systemic sclerosis (SSc, scleroderma) belongs to diseases connective tissue, characterized by chronic inflammation developing on an autoimmune background. The current state knowledge etiopathogenesis indicates existence many factors...
Systemic sclerosis (SSc) belongs to the group of systemic diseases connective tissue, which are characterized by a chronic autoimmune inflammatory process. P-glycoprotein, initially associated with drug resistance in patients cancer, becomes more and often subject considerations terms its significance development illnesses, including diseases. The aim study was an attempt answer question whether there relationship between ABCB1 polymorphisms morbidity Polish population. carried out 61 SSc...
AMA Dudarewicz M, Barańska Rychlik-Sych Trzciński R, Dziki A, Skrętkowicz J. The importance of C1236T polymorphism in the ABCB1/MDR1 gene assessment susceptibility to inflammatory bowel diseases Polish population. Gastroenterology Review/Przegląd Gastroenterologiczny. 2013;8(1):38-43. doi:10.5114/pg.2013.34181. APA Dudarewicz, M., Barańska, Rychlik-Sych, Trzciński, R., Dziki, A., & Skrętkowicz, (2013). Gastroenterologiczny, 8(1), 38-43. https://doi.org/10.5114/pg.2013.34181 Chicago Michał,...
AMA Dudarewicz M, Barańska Skrętkowicz J. Importance of selected polymorphisms ABCB1 (MDR1) gene in inflammatory bowel diseases. Gastroenterology Review/Przegląd Gastroenterologiczny. 2010;5(6):310-314. doi:10.5114/pg.2010.18473. APA Dudarewicz, M., Barańska, & Skrętkowicz, (2010). Gastroenterologiczny, 5(6), 310-314. https://doi.org/10.5114/pg.2010.18473 Chicago Michał, Małgorzata and Jadwiga Skrętkowicz. 2010. "Importance diseases". Gastroenterologiczny 5 (6): Harvard pp.310-314. MLA...