A5091748427- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Neutropenia and Cancer Infections
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- CNS Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cytomegalovirus and herpesvirus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- Medical and Biological Ozone Research
- Multiple and Secondary Primary Cancers
- Blood disorders and treatments
- Telomeres, Telomerase, and Senescence
- Antifungal resistance and susceptibility
- Transplantation: Methods and Outcomes
- Medical Imaging Techniques and Applications
- Cancer Treatment and Pharmacology
University Hospital Olomouc
2011-2024
Palacký University Olomouc
2013-2023
Ocní klinika
2007
University of Vienna
2005
Nemocnice České Budějovice
2002
We previously reported that the "Endothelial Activation and Stress Index" (EASIX; ((creatinine×lactate dehydrogenase)÷thrombocytes)) measured before start of conditioning predicts mortality after allogeneic hematopoietic stem cell transplantation (alloSCT) when used as continuous score. For broad clinical implementation, a prospectively validated EASIX-pre cut-off is needed defines high-risk cohort easy to use. In current study, we first performed retrospective analysis in n=2022 alloSCT...
The role of autologous hematopoietic stem cell transplantation (AHSCT) in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph-ALL) remains controversial. aim this retrospective study was to analyze results AHSCT and identify prognostic factors. Overall, 700 patients transplanted first complete remission between the years 1999-2020 were included. Median patient age 31.9 (68% male). B-cell precursor ALL (BCP-ALL) T-cell (TCP-ALL) diagnosed 35% 65%, respectively. Among...
Positron emission tomography using 2-[fluorine-18]-fluoro-2-deoxy-D-glucose ((18) F-FDG) is considered to be the most beneficial imaging method for staging patients with non-Hodgkin's lymphoma (NHL). The intensity of (18) F-FDG accumulation may determined by calculating so-called standardised uptake value (SUV). study aimed at assessing benefit SUV(max) determination in PET/CT untreated NHL.One hundred and forty-nine initial scans performed NHL between January 2007 August 2009 were assessed,...
Aims and objectives To establish the availability of High Efficiency Particulate Air (HEPA)‐ non HEPA ‐filtered rooms in eastern E uropean transplant centres to investigate impact on incidence pneumonia mortality after haematopoietic stem cell transplantation ( HSCT ). Background Barrier nursing is generally recommended for patients undergoing . There are only limited data mortality. Design A prospective, observational, international study. Methods Monitoring cards were distributed within...
Cases of synchronous non-Hodgkin lymphoma (NHL) and second primary carcinoma in previously untreated immunocompetent patients are relatively rare. The aim this part our prospective study was to a revealed 2-F-18 fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography (PET)-positive lesion an extranodal organ suggestive neoplasm newly diagnosed NHL patients.A total 209 with underwent initial staging F-18 FDG PET/computed (CT). finding assessed by radiologist, nuclear medicine...
Antibody (rituximab) dependent cellular cytotoxicity is a key mechanism in killing CD20+ lymphoma cells. FcγRIIIA-158 V/F gene polymorphism results expression of 3 variants the FcγRIIIA receptor (FcγRIIIA) on cytotoxic lymphocytes with different affinity. We studied 102 patients newly diagnosed FL to assess whether genotype influences outcome treated risk-adapted immunochemotherapy. The median age was 52 years (31-84); 90% had advanced (III/IV) clinical stages. Follicular Lymphoma...
Interleukin-6 (IL-6) is an important pro-inflammatory mediator implicated in immune-mediated complications of allogeneic haematopoietic stem cell transplantation (aHSCT). In accord with previous reports, this preliminary study on 56 donor-recipient pairs revealed IL-6-174 single nucleotide polymorphisms as a risk factor for the development acute graft-versus-host disease and decreased survival after aHSCT.
Peripheral T-cell lymphomas (PTCL) are infrequent subtypes of non-Hodgkin's lymphomas. The clinical course is aggressive and the median survival about 2-3 years. An optimal first-line chemotherapy protocol has not been established role high-dose therapy with autologous stem cell transplantation (ASCT) still unclear.To analyze long-term outcome unselected PTCL patients treated intensive ASCT.Here we report our experience 29 PTCL. histological were as follows: peripheral lymphoma, otherwise...
Abstract A somatic mutation of the human leukocyte antigen ( HLA )‐A gene revealed in tumour cells acute myelogenous leukemia AML ) is described. patient with and her siblings were routinely typed for order to find a suitable donor haematopoietic stem cell transplantation. Sequencing‐based typing initial patient's sample characterized by high proportion blasts unknown G/A exchange at position 781 ‐A (exon 4) associated ‐ A*02:01 allele. Importantly, this G781A variant was completely absent...
Click to increase image sizeClick decrease sizeKeywordsComparative genomic hybridizationMantle cell lymphomat(11;14)CCND1 geneFISH
Serum thymidine kinase 1 (TK1) is a sensitive marker of tumor cell proliferation. TK1 has been reported as reliable prognostic factor in solid tumors and chronic lymphocytic leukemia, but not yet tested large populations patients with non-Hodgkin lymphoma. In this study, the significance levels was assessed 170 prospectively enrolled previously untreated follicular lymphoma (FL). The level at time treatment initiation shown to correlate clinical stage, Follicular Lymphoma International...
This study analyzed the prognostic significance of soluble interleukin-2 receptor α (sIL-2Rα) levels in 100 prospectively enrolled patients with previously untreated follicular lymphoma. It showed that sIL-2Rα level ≥ 115 pmol/L at time treatment initiation correlated a high Follicular Lymphoma International Prognostic Index-2 (FLIPI-2), bulky disease, advanced clinical stage, number involved lymph nodes, bone marrow involvement and elevated β2-microglobulin (B2M) level. When testing all...
Although allogeneic haematopoietic stem cell transplantation (allo-HSCT) offers a unique curative potential, it may be connected with high treatment-related morbidity and mortality.Besides many organ complications, allo-HSCT significantly affect quality of life (QOL).Patients methods: Between January 2011 December 2012, five hundred ninety patients (pts) from 6 transplant centers in the Czech Republic filled questionnaire for quantitative measurement QOL using Functional Assessment Cancer...
Abstract: Objectives : To explore the safety and effectiveness of individually determined application granulocyte‐colony stimulating factor (G‐CSF) after autologous peripheral blood stem cell transplantation (ASCT). Methods The administration G‐CSF from day +5 (arm A) was compared in a randomised, controlled trial with delayed, (G‐CSF started when WBC ≥ 0.5 × 10 9 /L ANC 0.1 or at +10; arm B), placebo C). Results One hundred six patients, median age 45 (range 21–64), all malignant lymphoma...
Aim: The aim of the study was to control microbial contamination indoor air monitored monthly at Transplant Unit University Hospital Olomouc from August 2010 July 2011. Methods: unit is equipped with a three-stage filtration system HEPA filters. MAS-100 sampler (Merck, GER) used. Twenty locations were singled out for purposes collecting total 720 samplings air. Swabs HVAC diffusers sampling always carried after Results: In total, 480 samples taken Sabouraud chloramphenicol agar. 11 cases...
BACKGROUND: Nodal peripheral T-cell lymphomas (PTCLs) are infrequent subtypes of non-Hodgkin's lymphomas. The WHO classification recognizes three subgroups nodal PTCL: lymphoma not otherwise specified (PTCL, NOS), anaplastic large cell (ALCL) and angioimmunoblastic (AIL). clinical course is aggressive despite multiagent chemotherapy, the median survival about 2 years. Optimal first-line chemotherapy established role high-dose therapy with autologous stem support still controversial. AIM: To...
This is a case report of 51 year old male with marked splenomegaly, basophilia, severe thrombocytopenia, anemia and high SFKL phosphorylation downstream Bcr-Abl, investigated for association the e6a2 BCR-ABL fusion gene basophilia. The treatment strategy implications in patients Philadelphia positive CML are described.RT-PCR sequencing were carried out on peripheral blood leukocytes to detect type transcript. mutational status was assessed using RT-PCR products. vitro test sensitivity TKIs...