A5051915793- Ocular Oncology and Treatments
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Glaucoma and retinal disorders
- Immunotherapy and Immune Responses
- Lymphoma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Retinal Development and Disorders
- Hematopoietic Stem Cell Transplantation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hematological disorders and diagnostics
- Biomedical Ethics and Regulation
- Childhood Cancer Survivors' Quality of Life
- Cutaneous Melanoma Detection and Management
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Corneal surgery and disorders
- Bone and Joint Diseases
- Protease and Inhibitor Mechanisms
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Retinal and Macular Surgery
Ospedale Santa Maria
2023
Ospedale "Santa Maria delle Croci" di Ravenna
2017-2023
Fondazione IRCCS Istituto Nazionale dei Tumori
2021-2022
Sarcoma Oncology Center
2021
University of Geneva
2021
Ente Ospedaliero Ospedali Galliera
2012-2019
Ospedale Santa Corona
2017
Aziende Socio Sanitarie Territoriale di Crema
2015
Centre Antoine Lacassagne
2013
Istituti Ospitalieri di Cremona
2011
Uveal melanoma is the most frequent primary tumour of eye. It molecularly clearly distinct from cutaneous and shows a different pattern driver mutations. The influence sunlight ultraviolet (UV) exposure on aetiology uveal matter debate. recent identification mutations in promoter telomerase reverse transcriptase (TERT) gene with UV-induced cytidine-to-thymidine transitions prompted us to investigate whether these also occur melanoma. We analysed 50 cases obtained enucleation surgery for...
Venetoclax in combination with hypomethylating agents (HMA) is revolutionizing the therapy of acute myeloid leukemia (AML). However, evidence on large sets patients lacking, especially relapsed or refractory leukemia.AVALON a multicentric cohort study that was conducted Italy AML who received venetoclax-based therapies from 2015 to 2020. The approved by ethics committee participating institution and accordance Declaration Helsinki. effectiveness toxicity venetoclax + HMA 190 (43 newly...
Uveal melanoma is an aggressive cancer that metastasizes to the liver in about half of patients, with a high lethality rate. Identification patients at risk metastases may provide indication for frequent follow-up early detection and treatment. The analysis gene expression profiles primary human uveal melanomas showed SDCBP (encoding syndecan-binding protein-1 or mda-9/syntenin), which appeared higher recurrence, whereas syndecans was lower unrelated progression. Moreover, we found related...
Relatively little is known about the genetic aberrations of conjunctival melanomas (CoM) and their correlation with clinical histomorphological features as well prognosis. The aim this large collaborative multicenter study was to determine potential key biomarkers for metastatic risk any druggable targets high CoM. Using Affymetrix single nucleotide polymorphism genotyping arrays on 59 CoM, we detected frequent amplifications chromosome (chr) 6p deletions 7q, characterized mutation-specific...
Polycystin-2 (PC2), encoded by the PKD2 gene, mutated in 10-15% of autosomal-dominant polycystic kidney disease (ADPKD) patients, is a Ca2+-permeable cation channel present epithelia and other tissues. As PC2 was found expressed B-lymphoblastoid cells (LCLs) Ca2+ signaling pathways are important regulators B cell function activities, we investigated whether plays some role B-LCLs. In LCLs, mainly ER membranes but ~8 times less than HEK293 cells. The same reductions were PKD1 RNA; thus, PKD...
<b><i>Purpose:</i></b> To evaluate survival and clinical outcome for patients with a large uveal melanoma treated by either enucleation or proton beam radiotherapy (PBRT). <b><i>Procedures:</i></b> This retrospective non-randomized study evaluated 132 consecutive T3 T4 choroidal classified according to TNM stage grouping. <b><i>Results:</i></b> Cumulative all-cause mortality, melanoma-related mortality metastasis-free...
Uveal melanoma (UM) exhibits recurring chromosomal abnormalities and gene driver mutations, which are related to tumor evolution/progression. Almost half of the patients with UM develop distant metastases, predominantly liver, so far there no effective adjuvant therapies. An accurate genetic profile could assess individual patient's metastatic risk, provide basis determine an individualized targeted therapeutic strategy for each patient. To investigate presence specific alterations, BAP1...
Over the past 10 years recombinant activated factor VIIa (rFVIIa) has been successfully used for treatment and prophylaxis of bleeding in patients with platelet defects, including thrombocytopenia congenital acquired function abnormalities. Most reported data concern Glanzmann's thrombasthenia information available is still limited, especially surgery. We report on a 15-year-old girl ( approximately 60,000/microl) dysfunction (bleeding time 30 min, absent aggregation ATP secretion response...
Chromosome 6p amplification is associated with more benign behavior for uveal melanomas (UMs) an otherwise high risk of metastasis conferred by chromosome 3 monosomy. contains several members the B7 family immune regulator genes, including butyrophilin-like 2 (BTNL2; OMIM, 606000), which prostate cancer and autoimmune diseases.To investigate expression variant allele frequencies BTNL2, a candidate gene 6 amplification, in patients UM.In this case-control study, we analyzed BTNL2 UM cell...
Purpose To determine the influence of contour line position on Heidelberg Retina Tomograph (HRT) parameters and diagnostic capacity system. Methods Thirty subjects with clinical diagnosis primary open angle glaucoma 30 healthy were recruited. For each patient only one eye was randomly chosen. All optic nerve heads (ONH) analysed HRT. An operator drew right in all considered images, while a second user increased decreased radius size 0.05 0.1 mm, recalculating time HRT parameters. Five...