A5000217335- Neuroblastoma Research and Treatments
- Ocular Oncology and Treatments
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- ATP Synthase and ATPases Research
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Electrolyte and hormonal disorders
- Nanoplatforms for cancer theranostics
- Microtubule and mitosis dynamics
- Animal Virus Infections Studies
- Cancer therapeutics and mechanisms
- Renal Transplantation Outcomes and Treatments
- Muscle and Compartmental Disorders
- Phagocytosis and Immune Regulation
- Genomics and Chromatin Dynamics
- Cell death mechanisms and regulation
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Viral Infections and Immunology Research
- Venous Thromboembolism Diagnosis and Management
Ospedale Policlinico San Martino
2017-2024
University of Genoa
2001-2021
Istituto Giannina Gaslini
2014-2016
Université de Toulouse
2009
Curcumin has been reported to inhibit inflammation, tumor growth, angiogenesis and metastasis by decreasing cell growth inducing apoptosis mainly through the inhibition of nuclear factor kappa-B (NFκB), a master regulator inflammation. Recent reports also indicate potential metabolic effects polyphenol, therefore we analyzed whether how it affects energy metabolism cells. We show that curcumin (10 µM) inhibits activity ATP synthase in isolated mitochondrial membranes leading dramatic drop...
Glioblastoma progression in its early stages remains poorly understood. Here, we transfer PDGFB and genetic barcodes mouse brain to initiate gliomagenesis enable direct tracing of glioblastoma evolution from earliest possible stage. Unexpectedly, observe a high incidence clonal extinction events progressive divergence sizes, even after the acquisition malignant phenotype. Computational modeling suggests these dynamics result clonal-based cell-cell competition. Through bulk single-cell...
Background: Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating mutations in genes G-protein subunit alpha Q (GNAQ), 11 (GNA11), cysteinyl leukotriene receptor 2 (CYSLTR2), and phospholipase C beta 4 (PLCB4) metastasis-promoting splicing factor 3B1 (SF3B1), serine arginine rich (SRSF2), BRCA1-associated protein 1 (BAP1). Here, we tested hypothesis that additional mutations, though occurring only few cases (“secondary drivers”), might influence tumor development....
// Daniela Di Paolo 1 , D. Yang 2 Fabio Pastorino Laura Emionite 3 Michele Cilli Antonio Daga 4 Elisa Destafanis 1, 6 Annarita Fiore Francesca Piaggio Chiara Brignole Xiaobao Xu Chris Liang 5 James Gibbons Mirco Ponzoni * Patrizia Perri Laboratorio di Oncologia, Istituto G. Gaslini, Genoa, Italy Sundia MediTech Company, Ltd., Shangai, China Animal Facility, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Nazionale per la Ricerca sul Cancro, Trasferimento Genico, Xcovery LLC, West...
Glioblastoma is a lethal primary brain tumor lacking effective therapy. The secluded onset site, combined with the infiltrative properties of this tumor, require novel targeted therapies. In scenario, use oncolytic viruses retargeted to glioblastoma cells and able spread across represent an intriguing treatment strategy. Here, we tested specificity, safety efficacy R-613, first HSV fully EGFRvIII, variant epidermal growth factor receptor carrying mutation typically found in glioblastoma. An...
Abstract Glioblastoma continues to be a daunting obstacle in oncology research, with its early-stage progression being particularly enigmatic. In recent published work, we traced the clonal dynamics of glioblastoma evolution by simultaneous transfer PDGFB and genetic barcodes into mouse brains. We observed continuous loss during acquisition malignant phenotype, underlined modulation levels c-Myc expression their functional targets. this study, delve deeper transplanting multiclonal, glioma...
Abstract Oncolytic herpes simplex viruses (oHSVs) have shown promise as effective treatments against various cancers. Our study evaluated the efficacy of R-115, an oHSV retargeted to human Her2 (hHer2), fully virulent in its target cells and expressing murine interleukin 12 (mIL12), a high-grade, immunocompetent glioma model. This model is based on orthotopically transplant derived from PDGFB-induced primary gliomas syngeneic mice, engineered express hHer2. experimental design compared...
Abstract Curcumin has been reported to inhibit inflammation, tumor growth, angiogenesis and metastasis by decreasing cell growth inducing apoptosis mainly through the inhibition of nuclear factor kappa-B (NFkB), a master regulator inflammation. Recent reports also indicate potential metabolic effects polyphenol we therefore analyzed whether how it affects energy metabolism cells. We show that curcumin inhibits activity ATP-synthase in isolated mitochondrial membranes leading dramatic drop...
Abstract The depletion of tumor-associated macrophages (TAMs), involved in different stages cancer development and progression, is an appealing strategy therapy. We developed novel Clodronate-containing liposomes (Clo-Lipo-DOTAP) presenting good physicochemical properties (size distribution, polidispersity index Z-potential). In vitro, Clo-Lipo-DOTAP inhibited proliferation, reduced viability induced apoptosis a macrophage-like cell line dose- time-dependent manner. proof functionality...