A5012448755- Ocular Oncology and Treatments
- Cutaneous Melanoma Detection and Management
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ocular Infections and Treatments
- Corneal Surgery and Treatments
- Nonmelanoma Skin Cancer Studies
- Retinal and Macular Surgery
- CNS Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- melanin and skin pigmentation
- Retinal and Optic Conditions
- Brain Metastases and Treatment
- Lymphoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer Genomics and Diagnostics
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Cancer and Skin Lesions
- Ocular Disorders and Treatments
- Cancer-related Molecular Pathways
- Patient-Provider Communication in Healthcare
- Glioma Diagnosis and Treatment
- Optical Coherence Tomography Applications
University of Liverpool
2014-2024
University of Oxford
2019-2024
University College London
2020-2024
Moorfields Eye Hospital
2020-2024
S:t Eriks Ögonsjukhus
2022-2024
Nuffield Health
2024
Moorfields Eye Hospital NHS Foundation Trust
2020-2024
Karolinska Institutet
2023-2024
University of California, San Francisco
2014-2023
Nuffield Orthopaedic Centre
2020-2023
PurposeTo present the American Brachytherapy Society (ABS) guidelines for plaque brachytherapy of choroidal melanoma and retinoblastoma.Methods MaterialsAn international multicenter Ophthalmic Oncology Task Force (OOTF) was assembled to include 47 radiation oncologists, medical physicists, ophthalmic oncologists from 10 countries. The ABS-OOTF produced collaborative guidelines, based on their eye cancer–specific clinical experience knowledge literature. This work reviewed approved by ABS...
Metastasis from uveal melanoma occurs almost exclusively with tumors showing chromosome 3 loss. We used multiplex ligation-dependent probe amplification (MLPA) to detect 1p, 3, 6p, 6q, 8p, and 8q abnormalities in melanomas. The purpose of this study was correlate our MLPA results other risk factors metastatic death.Patients were included if they had a involving choroid. Correlations between baseline analyzed using the chi-square test (without Yates's adjustment) Mann-Whitney test, log-rank...
There is an unmet need for effective biological therapies relapsed central nervous system (CNS) lymphoma. Lenalidomide active in activated B-cell type diffuse large lymphoma and rituximab CNS These observations are the basis this first trial of immunomodulatory drug as monotherapy lymphoma, and, patients with inadequate responses to lenalidomide, rituximab. In independent cohort, we evaluated lenalidomide maintenance after salvage high-dose methotrexate or focal irradiation primary (PCNSL)....
purpose. To correlate monosomy 3 in uveal melanoma with clinical and histologic prognostic variables death caused by metastatic disease. methods. Loss of heterozygosity (LOH) on chromosome was investigated PCR-based microsatellite analysis 105 tumors related to large basal tumor diameter (LBD), ciliary body (CB) involvement, cell type, periodic acid-Schiff (PAS)-positive loops, A model relating these created forward-stepwise logistic regression used derive a index. results. Monosomy occurred...
The absence of BRCA1-associated protein 1 (BAP1) expression in uveal melanoma (UM) is associated with metastatic progression and reduced survival. In this study, we examine nuclear BAP1 (nBAP1) primary UMs (PUMs) that show both 'typical' 'atypical' clinical courses according to their chromosome 3 status, secondary hepatic UM (MUM), correlating the results histological, survival data.Nuclear was immunohistochemically assessed tissue microarrays (TMAs) of: (a) 68 PUM patients, who had been...
To evaluate multiplex ligation-dependent probe amplification (MLPA) of uveal melanoma as a predictive tool for metastatic death.Uveal specimens 73 patients treated between 1998 and 2000 were included. DNA samples analyzed with MLPA evaluating 31 loci on chromosomes 1, 3, 6 8, the results correlated death.The (27 women; 46 men) had median age 60.6 years follow-up 6.2 years. Metastatic death occurred in 28 patients, correlating most strongly chromosome 3 losses gains 8q (Cox univariate...
Purpose To refine the anatomic classification and staging of ciliary body choroidal melanomas in TNM classification. Patients Methods Tumor largest basal diameter thickness 7,369 patients were analyzed based on registry data from five ocular oncology centers. T categories derived empirically by dividing into blocks representing 3- × 3-mm fractions. Blocks with similar survival grouped together so that no category comprised a large majority tumors, each was uniform survival, using randomly...
A bstract This paper aims to stimulate debate on the terminology, classification, grading and staging of conjunctival melanosis melanoma. We audited our results with 76 invasive melanomas. Staging according sixth edition Tumour Node Metastasis (TNM) system did not correlate well tumour extent outcome. Approximately 50% melanomas were associated ‘primary acquired atypia’, a term which in opinion underestimates gravity this disease. also found deficiencies grading, terminology classification...
We estimated metastatic-death risk when the treatment of small choroidal melanomas is deferred until growth observed.
AIMS: The aims of this study were to report local tumour control after trans-scleral resection uveal melanoma and identify risk factors for (i) clinical residual recognised immediately surgery, (ii) delayed recurrence from subclinical microscopic deposits. METHODS: sample included 310 patients, treated by choroidectomy (188), cyclochoroidectomy (87), or iridocyclectomy (35), with follow up ranging 42 days 20.9 years (median 36 months), a mean basal largest diameter 13.2 mm, thickness 7.4 mm....