A5017849881- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cancer Treatment and Pharmacology
- Protein Degradation and Inhibitors
- Multiple and Secondary Primary Cancers
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Digital Imaging for Blood Diseases
- Medical Imaging Techniques and Applications
- Education, Psychology, and Social Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Nursing care and research
- Platelet Disorders and Treatments
- Chronic Myeloid Leukemia Treatments
- Renal Diseases and Glomerulopathies
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Hematological disorders and diagnostics
- Viral-associated cancers and disorders
- HER2/EGFR in Cancer Research
- Single-cell and spatial transcriptomics
University Hospital Olomouc
2021
Palacký University Olomouc
2021
General University Hospital in Prague
2005-2020
Cases of synchronous non-Hodgkin lymphoma (NHL) and second primary carcinoma in previously untreated immunocompetent patients are relatively rare. The aim this part our prospective study was to a revealed 2-F-18 fluoro-2-deoxy-D-glucose (F-18 FDG) positron emission tomography (PET)-positive lesion an extranodal organ suggestive neoplasm newly diagnosed NHL patients.A total 209 with underwent initial staging F-18 FDG PET/computed (CT). finding assessed by radiologist, nuclear medicine...
Background The data on the clinical utility of quantitative assessment immunophenotypes in distinguishing mature CD5‐positive B‐cell neoplasms is limited. study aim was to assess diagnostic value a panel 18 markers and identify most informative ones. Methods immunophenotype neoplastic population determined specimens from 188 patients. BD FACSCanto II flow cytometer FACSDiva software were used analyze positivity/negativity mean fluorescence intensity (MFI) surface expression markers. Advanced...
The main abnormalities associated with the increased risk of venous thrombosis are inherited deficiencies antithrombin, protein C, S, point mutations known as factor V Leiden and II G20210A. association other specific genes thrombotic is less known. G-308A polymorphism in promoter area gene coding for tumor necrosis α (TNF-α) an transcription activity this gene, TNF-α production subsequent predisposition to some illnesses. aim work was study link between deep (DVT). research determined...
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant condition with risk malignant conversion.With the aim to estimate cumulative MGUS progression hematologic malignancies, we analyzed nationwide population-based cohort 1887 patients from Czech Registry Gammopathies (RMG) between 2007 and 2013.During follow-up period (median 4 years; range 0.6-34.8), malignancies was observed in 8.6% (162 1887) patients. Factors associated were as follows: M-protein concentration ≥1.5...
Until recently, a combination of anti-CD20 antibody plus less intensive chemotherapy was standard care in elderly population with previously untreated chronic lymphocytic leukemia (CLL). The aim this observational study to retrospectively assess efficacy and safety obinutuzumab + chlorambucil (G-Clb), rituximab (R-Clb), bendamustine (BR) given as the frontline therapy within routine practice. final analyzed dataset included 398 consecutive CLL patients from 10 hematology centers cooperating...
The tissue microenvironment in chronic lymphocytic leukaemia (CLL) plays a key role the pathogenesis of CLL, but complex blood CLL has not yet been fully characterised. Therefore, immunophenotyping circulating immune cells 244 patients and 52 healthy controls was performed using flow cytometry analysed by multivariate Patient Similarity Networks (PSNs). Our study revealed high inter-individual heterogeneity distribution activation bystander depending on bulk cells. High counts were...
T-cell gamma/delta hepatosplenic lymphoma is a primary extranodal lymphoma, distinct from other T/LGL lymphomas. The clinical course aggressive, and despite use of the multiagent chemotherapy young age patients, median survival less than 1 year. Curability this disease still uncertain. We reported case successful intensive treatment with splenectomy, first line autologous stem cell transplant. High intensity cytarabine- platinum containing regimen (EDHAP) may overcome resistance to...
This study compared the use of bortezomib in different combination regimens newly diagnosed multiple myeloma (NDMM) patients who were transplant ineligible.We analyzed data from Registry Monoclonal Gammopathies (RMG) Czech Myeloma Group (CMG) to provide real-world evidence outcome for 794 MM ineligible patients. The most frequently used regimen was VCd (bortezomib-cyclophosphamide-dexamethasone) (47.5%) over VMP (bortezomib-melphalan-prednisone) (21.7%), BDd...
Abstract Background: The tissue microenvironment in chronic lymphocytic leukemia (CLL) plays a key role promoting neoplastic cell survival, proliferation, and drug resistance. There is lack of complex characterization CLL blood its clinical impact. Methods: Immunophenotypic profiles circulating immune cells 244 patients (untreated, n=123; novel agents, n=67; previous immunochemotherapy, n=54) age/sex-matched healthy controls (n=52) were assessed using flow cytometry analyzed by multivariate...
Abstract Background: The tissue microenvironment in chronic lymphocytic leukemia (CLL) plays a key role promoting neoplastic cell survival, proliferation, and drug resistance. There is lack of complex characterization CLL blood its clinical impact. Methods: Immunophenotypic profiles circulating immune cells 244 patients (untreated, n=123; novel agents, n=67; previous immunochemotherapy, n=54) age/sex-matched healthy controls (n=52) were assessed using flow cytometry analyzed by multivariate...