A5021565179- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Parvovirus B19 Infection Studies
- Viral gastroenteritis research and epidemiology
- Animal Disease Management and Epidemiology
- Molecular Biology Techniques and Applications
- Polyomavirus and related diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- CAR-T cell therapy research
- Mycobacterium research and diagnosis
- Cardiovascular Effects of Exercise
- Agriculture, Plant Science, Crop Management
- Microbial Metabolites in Food Biotechnology
- Fungal Infections and Studies
- Hematopoietic Stem Cell Transplantation
- Renal Transplantation Outcomes and Treatments
- T-cell and Retrovirus Studies
- Hepatitis Viruses Studies and Epidemiology
- Antifungal resistance and susceptibility
- Animal Virus Infections Studies
Medical University of Warsaw
2016-2025
Wojskowy Instytut Medycyny Lotniczej
2024
Central Clinical Hospital
2010-2018
University of Warsaw
2006-2013
Samodzielny Publiczny Centralny Szpital Kliniczny
2013
Czech Academy of Sciences, Institute of Microbiology
2010
While the true value of phage therapy (PT) in human bacterial infections still awaits formal confirmation by clinical trials, new data have been accumulating indicating that future PT may be applied treatment non-bacterial infections. Thus, "phage guests" interact with eukaryotic cells and such interactions immune system protect health (Guglielmi, 2017) cause clinically useful immunomodulatory anti-inflammatory effects when administered for therapeutic purposes (Górski et al., 2017; Van...
Aim: The objective of this study was to evaluate the effects T4 phage on adsorption and replication human adenovirus (HAdV). Materials & methods: Experiments were performed cell lines A549 HEK-293. Intracellular HAdV virions released titrated by Reed–Muench method. Results: significantly (p < 0.05) inhibited both viral in a dose-dependent manner. Mean reductions titer within range 0.634–2.12 0.238–1.88 log10 TCID50/ml for replication, respectively. Conclusion: can inhibit infections HAdV-5...
Introduction: Bacteriophages (viruses of bacteria) are used in the treatment antibiotic‑resistant infections. Moreover, they an important component mucosal microbiota. The objective this study was to investigate effects T4 and A5/80 bacteriophages on expression genes involved antimicrobial immunity, including Toll‑like receptors. Material/Methods: determined A549 cell line using RT2 Profiler PCR Array. Results: Purified phage preparations significantly affected 7 10 out 84 examined genes,...
Corneal transplants have one of the highest success rates among all transplantological procedures. Corneas intended for transplantation are stored in a preservation fluid, which is then tested bacterial and fungal infections. Among analyses infectious complications following corneal transplants, infections caused by bacteria or fungi most prominent. Surprisingly, however, apart from few publications, there lack data regarding occurrence viruses donor corneas risk transmitting these to their...
Adenovirus infections tend to be mild, but they may pose a serious threat for young and immunocompromised individuals. The treatment is complicated because there are no approved safe specific drugs adenovirus infections. Here, we present evidence that 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG), an inhibitor of Hsp90 chaperone, decreases the rate human 5 (HAdV-5) replication in cell cultures by 95%. 17-AAG inhibited transcription early late genes HAdV-5, viral DNA, expression proteins....
Human herpesvirus 6 (HHV-6) has been recognized as a potentially significant pathogen in hemopoietic stem cell transplant (HSCT) recipients. Different clinical manifestations have described, including fever, skin rash, bone marrow suppression, and encephalitis. A retrospective review of group 26 adult recipients allogeneic HSCTs was conducted. Serum samples taken before were examined for the presence specific anti-HHV-6 IgM IgG antibodies. After transplantation, quantitative real-time PCR...
<b><i>Background/Aims:</i></b> Bacteriophages (phages) are viruses of bacteria. <i>Escherichia coli</i> phage (T4) can potentially interfere with adsorption HAdV-5 to cellular integrins by its KGD motif, while staphylococcal A5/80 does not possess this structure. The objective study was investigate the effects T4 and preparations on type 5 human adenovirus (HAdV-5) DNA synthesis expression genes. <b><i>Methods:</i></b> Experiments...
Understanding the meaning of parvovirus B19 (PB19V) in an etiology dilated cardiomyopathy (DCM) is difficult. Viruses change dynamics mitochondria by interfering with mitochondrial process/function, causing alteration morphology. In this study, ultrastructural changes endomyocardial biopsy (EMB) samples from patients DCM and PB19V were determined. The evaluation was performed EMB specimens real-time PCR 20 (age: 28 ± 6 years). examined histo- immunohistochemistry to detect inflammatory...
<i>Objectives:</i> Human herpesvirus 7 (HHV-7) is spread worldwide and has been described as a potential pathogen in immunosuppressed patients. Different clinical manifestations have including fever skin rash; HHV-7 may also be possible cofactor for cytomegalovirus disease transplant recipients. <i>Materials Methods:</i> A retrospective review of group 58 adult recipients allogeneic hemopoietic stem cell transplantation was made. Serum samples taken the range 0–180...
Viral infections of the heart cause serious clinical problems, either as infectious myocarditis, which usually is a consequence acute infection or idiopathic dilated cardiomyopathy, resulting rather from chronic infection. This minireview presents an up-to-date view on pathomechanisms viral tissues, role immune system in controlling process at its various stages and current possibilities recognizing with use both cardiological virological methods. Our goal was to present variety known agents...
The meaning of viral nucleic acids in the myocardium many cases is difficult for clinical interpretation, whereas presence serum a marker active infection. We determined diagnostic value ventricular and peripheral samples comparison with endomyocardial biopsy (EMB) specimens patients clinically suspected myocarditis.The acid evaluation was performed EMB by real-time PCR 70 (age: 47 ± 16 years). were examined histo- immunohistochemistry to detect inflammatory response.The detected serum, 10...