A5013366559- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Polyomavirus and related diseases
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Clostridium difficile and Clostridium perfringens research
- Viral gastroenteritis research and epidemiology
- Parvovirus B19 Infection Studies
- Gut microbiota and health
- Molecular Biology Techniques and Applications
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Viral Infections and Vectors
- Agriculture, Plant Science, Crop Management
- Vector-borne infectious diseases
- Hepatitis B Virus Studies
- Mycobacterium research and diagnosis
- CAR-T cell therapy research
- Antifungal resistance and susceptibility
- Toxoplasma gondii Research Studies
- Multiple Sclerosis Research Studies
- Vector-Borne Animal Diseases
Medical University of Warsaw
2015-2024
Central Clinical Hospital
2010-2021
Institute of Physiology and Pathology of Hearing
2018
National Institutes of Health
2017
University of Toronto
2017
National Cancer Institute
2017
Centralny Szpital Kliniczny
2015
Samodzielny Publiczny Centralny Szpital Kliniczny
2013
University of Warsaw
2013
Czech Academy of Sciences, Institute of Microbiology
2010
Patients with blood disorders colonized antibiotic-resistant bacteria (ARB) are prone to systemic infections that difficult treat. Reintroduction of commensal in a murine model enterococcal colonization the gut can lead eradication enterococci. We hypothesized fecal microbiota transplantation (FMT) could be used eradicate ARB humans.Participants were treated intraduodenal FMT according prospective protocol (NCT02461199). The primary endpoint was complete decolonization at 1 month after FMT....
In summer 2023, during an outbreak of highly pathogenic avian influenza (HPAI) in cats Poland, a 16-year-old dog was presented to the veterinary clinic with persistent, debilitating, dry cough, submandibular lymphadenomegaly, mild serous nasal discharge, and left apical heart murmur. A preliminary diagnosis kennel cough made treatment amoxicillin/clavulanic acid dexamethasone initiated. Due lack improvement within 2 days, blood check-up, thoracic radiography ultrasonography, echocardiography...
Tick-borne encephalitis virus (TBEV) infection has become a major health problem in Europe and is currently common cause of viral brain many countries. Encephalitis transplant recipients, althrough rare, becoming recognized complication. Our study provides the first description transmission TBEV through transplantation solid organs.Three patients who received organ transplants from single donor (2 kidney, 1 liver) developed 17-49 days after subsequently died. Blood autopsy tissue samples...
The study involved five ferrets from one household in Poland, comprising three sick 9-week-old juveniles, their healthy mother, and another clinically normal adult, admitted to the veterinary clinic June 2023. juvenile displayed significant lethargy a pronounced unwillingness move with accompanying pulmonary distress. Prompted by concurrent outbreaks of A/H5N1 influenza virus infections Polish cats, point-of-care tests were conducted that revealed type A antigens throat swabs all ferrets....
Abstract Identification of pathogens causing viral encephalitis remains challenging, and in over 50% cases the etiologic factor undetermined. Next-generation sequencing (NGS) based metagenomics has been successfully used to detect novel rare infections, but its value for routine diagnosis unclear. The aim present study was determine sensitivity shotgun metagenomic protocols, which include preamplification, testing it against cerebrospinal fluid (CSF) samples from patients. For HIV HBV...
The objective of this work was to compare the quality FMT preparations made from fresh feces with those frozen at -30°C without any pre-processing or cryopreservation additives. research hypothesis that such preservation protocol (frozen whole stool, then thawed and processed) is equipotent classical preparation. For that, three complementary methods were applied, including: (i) culturing in aerobic anaerobic conditions, (ii) measuring viability by flow cytometry, (iii) next-generation...
A European Shorthair male cat, neutered, approximately 6 years of age, was presented to the veterinary clinic due apathy and anorexia. The cat lived mostly outdoors fed raw chicken meat. After 3 days diagnostic procedures symptomatic treatment, respiratory distress neurological signs developed progressed into epileptic seizures, followed by cardiac arrest within next days. Post-mortem examination revealed necrotic lesions in liver, lungs, intestines. Notably, brain displayed perivascular...
Encephalitis is a severe neurological syndrome associated with high morbidity and mortality as well long-term sequelae. Despite being an important public health problem, very few extensive population-based studies were conducted so far in the world none Central Europe. Altogether 114 consecutive patients meeting initial criteria for encephalitis enrolled at Warsaw Hospital Infectious Diseases between June 2012 July 2015. Eighteen secondarily excluded from analysis due to incomplete data or...
Abstract Fecal microbiota transplantation (FMT) was performed to decolonize gastrointestinal tract from antibiotic‐resistant bacteria before allogeneic hematopoietic cells (alloHCT). AlloHCT complicated by norovirus gastroenteritis, acute graft‐versus‐host disease, and eosinophilic pancolitis. Norovirus identified in samples FMT material. Symptoms resolved after steroids course second norovirus‐free another donor.
Equine herpesvirus-1 (EHV-1) infections cause significant economic losses for equine industries worldwide as a result of abortion, respiratory illness, and neurologic disease in all breeds horses.The occurrence abortions caused by EHV-1 has repeatedly been confirmed Poland, but neurological manifestations the infection have not described yet.Also it is unknown how neurons with non-neuropathogenic strains regulated.To further understand virus-neuron interaction we studied two murine primary...
Equine herpesvirus type 1 (EHV-1) causes respiratory disease, abortion and neurological disorders in horses. In the present study, we investigated reorganization of cytoskeleton neurons infected with two EHV-1 strains: Jan-E (wild-type strain) Rac-H (attenuated strain). The studies were performed on primary murine neurons, which are an excellent model for studying neurotropism neurovirulence EHV-1. We have demonstrated first time that infection rearrangements actin network dependent virus...
Abstract Human pegivirus (HPgV), previously called hepatitis G virus or GB C, is a lymphotropic with undefined pathology. Because many viruses from the family Flaviviridae, to which HPgV belongs, are neurotropic, we studied whether could infect central nervous system. We tested serum and cerebrospinal fluid samples 96 patients diagnosis of encephalitis for variety pathogens by molecular methods serology; also autoantibodies against neuronal antigens. found in 3 who had unclear origin; that...
Coronavirus disease 2019 (COVID-19) is an infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), declared a global pandemic the World Health Organization (WHO). The three key principles in management of COVID-19 are prevention, early detection and targeted treatment. Vaccine-based prevention together with has already proven its efficacy controlling pandemic. Early infected patients could substantially accelerate implementation treatment, but also help to identify...
The xCELLigence system for real-time and label-free analysis of neuronal dermal cell response to Equine Herpesvirus type 1 infection Real-time electronic sensing (RT-CES) based on impedance measurements is an emerging technology analyzing the status cells in vitro . It allows label-free, real time monitoring biological cells. present study was designed assess dynamic data processes during equine herpesvirus (EHV-1) ED (equine dermal) primary murine culture. We have demonstrated that with can...