A5001249552- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Gastrointestinal motility and disorders
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Antibiotics Pharmacokinetics and Efficacy
- Clinical Nutrition and Gastroenterology
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Viral gastroenteritis research and epidemiology
- Chronic Lymphocytic Leukemia Research
- Agriculture, Plant Science, Crop Management
- Oral health in cancer treatment
- Multiple Myeloma Research and Treatments
- Viral-associated cancers and disorders
- Antibiotic Resistance in Bacteria
- Cardiovascular Effects of Exercise
- Childhood Cancer Survivors' Quality of Life
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- Nosocomial Infections in ICU
- Fungal Infections and Studies
- Herbal Medicine Research Studies
Medical University of Warsaw
2015-2024
Goethe University Frankfurt
2017
Collegium Medicum in Bydgoszcz
2014
Patients with blood disorders colonized antibiotic-resistant bacteria (ARB) are prone to systemic infections that difficult treat. Reintroduction of commensal in a murine model enterococcal colonization the gut can lead eradication enterococci. We hypothesized fecal microbiota transplantation (FMT) could be used eradicate ARB humans.Participants were treated intraduodenal FMT according prospective protocol (NCT02461199). The primary endpoint was complete decolonization at 1 month after FMT....
Gut colonization by antibiotic-resistant bacteria may underlie hard-to-treat systemic infections. There is also accumulating evidence on the immunomodulatory function of gut microbiota after allogeneic stem cell transplantation (alloSCT) and its impact graft-versus-host disease (GVHD). We investigated epidemiology clinical alloSCT retrospectively analyzed data 107 alloSCTs performed at a single transplant center. Pretransplant microbiology screening identified in 31% cases. Colonization had...
The objective of this work was to compare the quality FMT preparations made from fresh feces with those frozen at -30°C without any pre-processing or cryopreservation additives. research hypothesis that such preservation protocol (frozen whole stool, then thawed and processed) is equipotent classical preparation. For that, three complementary methods were applied, including: (i) culturing in aerobic anaerobic conditions, (ii) measuring viability by flow cytometry, (iii) next-generation...
The gut microbiota serves a crucial role in the development of host immunity. Immunocompromised patients are particularly vulnerable to dysbiosis not only by virtue defect immune system but also due increased susceptibility infection and multiple courses antibiotic therapy. Fecal transplantation is far most effective option for restoring gastrointestinal homeostasis. However, it contraindicated with significant primary secondary immunodeficiencies. This article presents case 59-year-old...
Abstract Fecal microbiota transplantation (FMT) was performed to decolonize gastrointestinal tract from antibiotic‐resistant bacteria before allogeneic hematopoietic cells (alloHCT). AlloHCT complicated by norovirus gastroenteritis, acute graft‐versus‐host disease, and eosinophilic pancolitis. Norovirus identified in samples FMT material. Symptoms resolved after steroids course second norovirus‐free another donor.
There is a widespread lack of systematic knowledge about myocarditis in children and young adults European populations. The MYO-PL nationwide study aimed to evaluate sex differences the incidence, clinical characteristics, management outcomes all patients with diagnosis myocarditis, hospitalized last ten years. involved data (from only public healthcare insurer Poland) (n = 3659) aged 0-20 years for 2011-2019. We assessed five-year outcomes. Males comprised 75.4% population. standardized...
Significant progress has been made in understanding the connection between intestinal barrier function and allogenic hematopoietic cell transplantation (allo-HCT) recipients' outcomes. The purpose of this study was to further evaluate gut permeability other potential disruption markers allo-HCT setting. Fifty-one patients were enrolled study. Intestinal assessed with sugar absorption test faecal concentrations zonulin, calprotectin beta-defensin-2 levels peri-transplantation period. Most...
Methods of stool assessment are mostly focused on next-generation sequencing (NGS) or classical culturing, but only rarely both. We conducted a series experiments using multi-method approach to trace the stability gut microbiota in various donors over time, find best method for proper selection fecal and “super-donor” indicators. Ten consecutive stools donated by each three were used (30 total). The assessed bacterial viability measured flow cytometry, culturing different media conditions,...