A5089363832- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Multiple Myeloma Research and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Systemic Sclerosis and Related Diseases
- Advanced Breast Cancer Therapies
- Neutropenia and Cancer Infections
- Erythropoietin and Anemia Treatment
- Viral-associated cancers and disorders
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Blood disorders and treatments
- Peptidase Inhibition and Analysis
- Cancer Treatment and Pharmacology
- Multiple and Secondary Primary Cancers
- Polish Legal and Social Issues
- Iron Metabolism and Disorders
- Antifungal resistance and susceptibility
Medical University of Warsaw
2015-2024
Polish Stem Cell Bank
2004-2021
Centralny Szpital Kliniczny
1997-2019
Goethe University Frankfurt
2017
Samodzielny Publiczny Centralny Szpital Kliniczny
2015
Wojskowy Instytut Medyczny
2004-2013
Hospital Universitario Virgen del Rocío
2011
Medical University of Białystok
2010
Medical University of Lublin
2010
Medical University of Lodz
2010
Patients with blood disorders colonized antibiotic-resistant bacteria (ARB) are prone to systemic infections that difficult treat. Reintroduction of commensal in a murine model enterococcal colonization the gut can lead eradication enterococci. We hypothesized fecal microbiota transplantation (FMT) could be used eradicate ARB humans.Participants were treated intraduodenal FMT according prospective protocol (NCT02461199). The primary endpoint was complete decolonization at 1 month after FMT....
PURPOSE Little is known about comparison of the activity different purine nucleoside analogs in chronic lymphocytic leukemia (CLL). We conducted a randomized phase III trial to compare efficacy and safety cladribine fludarabine, each combined with cyclophosphamide, previously untreated progressive CLL. PATIENTS AND METHODS Patients received at 0.12 mg/kg cyclophosphamide 250 mg/m(2) for 3 days intravenously (CC regimen) or fludarabine 25 (FC regimen), every 28 up six cycles. The primary end...
Abstract: Between January 1991 and December 1997, 103 patients, 97 with typical hairy cell leukemia (HCL) 6 HCL‐variant (HCL‐V) were treated 2‐chlorodeoxyadenosine (2‐CdA) given as 2‐h infusion for 5 consecutive d at a daily dose 0.12 mg/kg. To our knowledge this is the largest cohort of HCL patients type regimen. Median follow‐up amounted to 36 months. Fifty‐six newly diagnosed 41 relapsed after previous treatment. Splenectomy first‐line therapy was performed in 23 18 remaining received...
Forty one patients with hairy cell leukemia (HCL) were treated 2-chloro-deoxyadenosine (2-CdA) administered in various schedules. Complete remission (CR) was achieved 31 (76%) and partial (PR) 9 (22%). The mean duration of (CR + PR) 25.2 months (range 9—45 months). One patient did not respond to therapy. Twelve out 16 (75%) CR after 5-day intravenous infusions 2-CdA 19 25 7-day courses. In 23 (82.6%) intermittent 2-hour 12 18 (66.7%) continuous 24-hour infusion. differences statistically...
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the sole potential cure for paroxysmal nocturnal hemoglobinuria (PNH); however, data on its utility in PNH are limited. This retrospective analysis of patients with who underwent allo-HSCT 11 Polish centers between 2002 and 2016 comprised 78 PHN, including 27 classic (cPNH) 51 bone marrow failure-associated (BMF/PNH). The cohort was 59% male, a median age 29 years (range, 12 to 65 years). There history thrombosis 12% hemolysis...
Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal stem cell disorders characterized by ineffective hematopoiesis, cytopenias and risk progression to acute myeloid leukemia (AML). Anemia is the most frequent cytopenia diagnosed in patients with MDS. Regular RBC transfusions only treatment option for about 40% patients. Transfusion-dependent develop secondary iron overload. The influence serum ferritin (SF) concentration on survival transformation MDS remains controversial....
Very few reports have been published to date on the bloodstream infections caused by Saccharomyces spp. in oncohaematological patients, and there are no guidelines use of this probiotic microorganism population. We describe preparation containing boulardii a large group patients. retrospectively analysed data from 32,000 patient hospitalisations at haematological centre during 2011-2013 (including 196 haematopoietic stem cell transplant recipients) tertiary care university-affiliated...
Abstract Introduction Dialysis‐dependent ( DD ) multiple myeloma patients MM have a poor prognosis and high tumour burden, thus may benefit from autologous peripheral blood stem cell transplantation (auto‐ PBSCT ), however, these an increased risk of toxicity. Aims To evaluate the outcomes (toxicity, PFS , OS dose therapy followed by auto‐ during observational study after propensity score matching. Patients methods Between 2004‐2015, 24 patients, (aged 38‐67 years), ISS 3, treated with...
The purpose of our study was to determine the efficacy 2-chlorodeoxyadenosine (2-CdA) administered in 2-hour intravenous infusions previously treated patients with low grade non-Hodgkin's lymphoma (LGNHL). We 94 LGNHL 2-CdA at a dosage 0.12 mg/kg/24h infusion for 5 consecutive days. treatment consisted from 1 7 courses (median 3), repeated usually monthly intervals. All were refractory or relapsed after standard chemotherapy. Of these 78 (83%) had clinical stage IV disease. Complete response...
The purpose of our study was to determine the effectiveness 2-CdA in 2-hour intravenous infusions treatment B-CLL. One hundred and ten patients with B-CLL received 1 10 courses (median 2.5) at a dosage 0.12 mg/kg daily for 5 consecutive days. Eighteen them were untreated 92 relapsed or became refractory previous therapeutic modalities. Complete remission (CR) achieved 8 (7.3%) partial (PR) 35 (31.8%) giving an overall response rate 39.1%. In 3 patients, cross-resistance fludarabine noticed....
Epidemiological studies on myelodysplastic syndromes (MDS) in Middle-Eastern Europe are scarce. No data about the demographic, clinical, and laboratory features of Polish MDS patients have been published. The aim this study was to assess epidemiological toxic exposure their association with hematological parameters clinical outcomes. For 15 months, 966 living were enrolled at 24 centers (12 university 12 community hospitals). Follow-up conducted for next 55 months. percentage older than 80...
Abstract Background Salvage autologous hematopoietic stem cell transplantation (autoHSCT) may be used to treat relapse of multiple myeloma occurring after previous autoHSCT. When insufficient number cells was stored from the initial harvest, remobilization is necessary. Purpose The analysis Patients and Methods Fifty‐eight patients, 60% males, median 59 years, were included. Median time interval between autoHSCT 42 months. first performed mostly chemotherapy: cyclophosphamide (33%),...
Abstract Atypical chronic myeloid leukaemia (aCML) belongs to myelodysplastic/myeloproliferative neoplasms. Because of its rarity and changing diagnostic criteria throughout subsequent classifications, data on aCML are very scarce. Therefore, we at the Polish Adult Leukemia Group performed a nationwide survey aCML. Eleven biggest centres participated in study. Altogether, 45 patients were reported, among whom only 18 (40%) fulfilled criteria. Among misdiagnosed patients, syndrome...