A5059212245- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Genomic variations and chromosomal abnormalities
- Chromosomal and Genetic Variations
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Hemoglobinopathies and Related Disorders
- Cytomegalovirus and herpesvirus research
- Kruppel-like factors research
- Childhood Cancer Survivors' Quality of Life
- Erythropoietin and Anemia Treatment
- Multiple Myeloma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- Diphtheria, Corynebacterium, and Tetanus
- Neutropenia and Cancer Infections
- Infectious Diseases and Mycology
Instytut Hematologii i Transfuzjologi
2015-2025
Polish Stem Cell Bank
2006-2018
Institute of Haematology and Blood Transfusion
2008-2012
Medical University of Białystok
2010
Medical University of Warsaw
2010
Medical University of Lublin
2010
Medical University of Lodz
2010
Tulane University
1989
The treatment of adults with Philadelphia-negative acute lymphoblastic leukaemia (ALL) depends on the presence risk factors including age, white blood cell count, immunophenotype and time to complete remission. In recent years, status minimal residual disease (MRD) has been postulated as an additional criterion. This study prospectively evaluated significance MRD. Patients were treated a uniform Polish Adult Leukemia Group (PALG) 4-2002 protocol. MRD was assessed after induction...
PURPOSE Little is known about comparison of the activity different purine nucleoside analogs in chronic lymphocytic leukemia (CLL). We conducted a randomized phase III trial to compare efficacy and safety cladribine fludarabine, each combined with cyclophosphamide, previously untreated progressive CLL. PATIENTS AND METHODS Patients received at 0.12 mg/kg cyclophosphamide 250 mg/m(2) for 3 days intravenously (CC regimen) or fludarabine 25 (FC regimen), every 28 up six cycles. The primary end...
Abstract BCR/ABL kinase–positive chronic myelogenous leukemia (CML) cells display genomic instability leading to point mutations in various genes including bcr/abl and p53, eventually causing resistance imatinib malignant progression of the disease. Mismatch repair (MMR) is responsible for detecting misincorporated nucleotides, resulting excision before occur and/or induction apoptosis avoid propagation carrying excessive DNA lesions. To assess MMR activity CML, we used an vivo assay using...
Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous recombination DNA-dependent protein kinase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas repair pathways mediated poly(ADP)ribose polymerase 1 (PARP1) serve as backups. Here we have designed a personalized medicine approach called gene expression mutation analysis (GEMA) to identify BRCA- DNA-PK-deficient leukemias...
Abstract Myeloproliferative neoplasms (MPNs) are uncommon in children/young adults. Here, we present data on unselected patients diagnosed before 25 years of age included from 38 centers 15 countries. Sequential were included. We identified 444 patients, with median follow-up 9.7 (0-47.8). Forty-nine (11.1%) had a history thrombosis at diagnosis, 49 new thrombotic events recorded (1.16% patient per year [pt/y]), perihepatic vein thromboses most frequent (47.6% venous events), and logistic...
Activation of adaptive mechanisms plays a crucial role in cancer progression and drug resistance by allowing cell survival under stressful conditions. Therefore, inhibition the response is considered as prospective therapeutic strategy. The PERK-eIF2α phosphorylation pathway an important arm unfolded protein (UPR), which induced conditions endoplasmic reticulum (ER) stress. Our previous work showed that ER stress chronic myeloid leukemia (CML) cells. Herein, we demonstrate upregulated CML...
Failure to comply with treatment recommendations is very common in patients, but still poorly recognised by doctors. The current practice of using oral therapy on a large scale has been increasingly adopted for cancer patients. Chronic myeloid leukaemia (CML) just such an example, where the introduction taking new medications, tyrosine kinase BCR-ABL inhibitors (TKI), now revolutionised treatment. aim our study was assess adherence group Polish CML patients (a survey conducted 140 patient...
AbstractBCR/ABL-positive leukemia cells accumulated more replication-dependent DNA double-strand breaks (DSBs) than normal counterparts after treatment with cisplatin and MMC, as assessed by pulse field gel electrophoresis (PFGE) neutral comet assay. In addition, could repair these lesions efficiently eventually survive genotoxic treatment. Elevated levels of drug-induced DSBs in were associated higher activity ATR kinase, enhanced phosphorylation histone H2AX on serine 139 (γ-H2AX). γ-H2AX...
The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the response. ISR activation was reported in neurological disorders and solid tumors; however, function of its role as a possible therapeutic target hematological malignancies still remain largely unexplored. Previously, we showed that is activated chronic myeloid leukemia (CML) cells correlates with blastic transformation tyrosine kinase inhibitor (TKI) resistance. Moreover,...
Abstract Essential thrombocythemia (ET) and polycythemia vera (PV) are rare in adolescent young adult (AYA). These conditions, similar to those older patients, linked with thrombotic complications the potential progression secondary myelofibrosis (sMF). This retrospective study of ET PV patients diagnosed before age 25 evaluated complication rates impact cytoreductive drugs on outcomes. Among 348 (278 ET, 70 PV) a median 20 years, events was 1.9 per 100 patient-years. Risk factors for...
Erythropoietin (Ep) levels in spent culture media of a Hep G2 human hepatoblastoma cell line were measured by radioimmunoassay (RIA), fetal mouse liver erythroid colony formation (FMLC), and the exhypoxic polycythemic assay (EHPCMA). The cells at high density produced approximately 700 mU/ml Ep when with RIA. On other hand, assayed EHPCMA FMLC 50 2,600 mU/ml, respectively. bioactivity was completely neutralized an antibody to purified recombinant Ep, indicating that erythropoietic activity...
Abstract Background Toxigenic strains of Corynebacterium diphtheriae are well known agent diphtheria. Nontoxigenic can cause atypical course the disease. Invasive diseases caused by C. occur very rare. Case presentation We have described first case septicemia and endocarditis due to nontoxigenic biotype gravis in Poland. The patient has not belonged any group risk such infection. Conclusion presented this article shows unusual infection connected with that took place area where been no cases...
Abstract A small subgroup of patients with hypereosinophilic syndrome (HES) demonstrates imatinib‐sensitive fusion transcript—the FIP1L1‐PDGFRA (F/P+). These cases are currently diagnosed as chronic eosinophilic leukaemia (CEL). In this paper, we screened 77 to estimate the frequency transcript among unexplained, long‐term hypereosinophilia exceeding 1.5 × 10 9 /L and analyse clinical serological features in F/P+ CEL population. The chimeric protein was detectable 16 (14 males 2 females) out...
Our present study was undertaken to determine the serum erythropoietin concentration (radioimmunoassay), hematocrit, red cell mass, and body weight of mice exposed hypoxia in a hypobaric chamber (0.42 atm, 22 h/day) for 14 days during 10 posthypoxic at ambient pressure clarify correlation mass production hypoxia. The mean titer 326.23 +/- 77.04 mU/ml after 2 days, reached highest level 3 (452.2 114.5 mU/ml), then gradually declined 36.5 11.4 hypoxia, undetectable 10-day period. hematocrit...