A5062294584- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- PI3K/AKT/mTOR signaling in cancer
- Antifungal resistance and susceptibility
- Cytokine Signaling Pathways and Interactions
- Respiratory viral infections research
- Histone Deacetylase Inhibitors Research
- Immunodeficiency and Autoimmune Disorders
- Advanced Breast Cancer Therapies
- Circular RNAs in diseases
- Agriculture, Plant Science, Crop Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Fungal Infections and Studies
- Polish socio-economic development
- Lipid metabolism and disorders
- finance, banking, and market dynamics
- Powdery Mildew Fungal Diseases
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
Instytut Hematologii i Transfuzjologi
2010-2025
Hudson Institute
2019
John Wiley & Sons (United States)
2019
Central Clinical Hospital
2015
Failure to comply with treatment recommendations is very common in patients, but still poorly recognised by doctors. The current practice of using oral therapy on a large scale has been increasingly adopted for cancer patients. Chronic myeloid leukaemia (CML) just such an example, where the introduction taking new medications, tyrosine kinase BCR-ABL inhibitors (TKI), now revolutionised treatment. aim our study was assess adherence group Polish CML patients (a survey conducted 140 patient...
We retrospectively analyzed the rates of significant non-hematological adverse events (AEs) in 105 patients with chronic myeloid leukemia (CML) treated second-generation tyrosine kinase inhibitor (TKIs) dasatinib or nilotinib used as second-line therapy Polish tertiary care centers. Our analysis revealed that a "real life setting," nearly half CML on TKIs suffer from complications. Grade 2-5 AEs were observed 40% and 42% (p=0.83). Severe vascular including peripheral artery occlusive disease...
Abstract Background The standard first‐line treatment for primary mediastinal B‐cell lymphoma (PMBCL) patients is rituximab‐based immunochemotherapy; however, this not due to the result of randomized clinical trials. Aims We retrospectively investigated 53 PMBCL patient outcomes treated either with R‐CHOP‐21 or DA‐EPOCH‐R‐28. endpoint was overall survival (OS). Secondary endpoints were complete remission (CR), response rate (ORR), progression‐free (PFS), and treatment‐related complications....
Abstract Spleen tyrosine kinase (SYK) is an important oncogene and signaling mediator activated by cell surface receptors crucial for acute myeloid leukemia (AML) maintenance progression. Genetic or pharmacologic inhibition of SYK in AML cells leads to increased differentiation, reduced proliferation, cellular apoptosis. Herein, we addressed the consequences stem-cell (LSC) function assessed SYK-associated pathways biology. Using gain-of-function MEK mutant constitutively active STAT5A,...
Background/Objectives: The risk of post-transplantation lymphoproliferative disorder (PTLD) varies according to the type transplanted organ. To investigate factors contributing PTLD development and treatment outcomes, we established a multicenter registry that included patients diagnosed with within population 13,263 kidney, liver, lung transplant recipients (KTRs, LTRs, LngTRs, respectively), observed in period between 2000 2023. Methods: chi-squared test was used analyze differences group...
Abstract Patients with hematologic malignancies are particularly vulnerable to severe infectious complications. SARS‐CoV‐2 infection is associated a high risk of course and death in this patient population. In addition, immune deficits both the blood cancer treatment used make vaccination against less effective than immunocompetent individuals. Molnupiravir one first oral antiviral drugs demonstrate significant benefit reducing hospitalisation COVID‐19 general context, 175 haematology...
Epidemiological studies on myelodysplastic syndromes (MDS) in Middle-Eastern Europe are scarce. No data about the demographic, clinical, and laboratory features of Polish MDS patients have been published. The aim this study was to assess epidemiological toxic exposure their association with hematological parameters clinical outcomes. For 15 months, 966 living were enrolled at 24 centers (12 university 12 community hospitals). Follow-up conducted for next 55 months. percentage older than 80...
Bing-Neel syndrome (BNS) is a rare presentation of Waldenström macroglobulinemia (WM). BNS consequence the central nervous system (CNS) involvement by lymphoplasmacytic lymphoma (LPL) and, rarely, peripheral system. The data on are extremely scarce. Therefore, we performed multicenter retrospective analysis patients diagnosed and treated in centers aligned with Polish Lymphoma Research Group. covers years 2014–2021. Eleven were included, 55% females median age at diagnosis was 61 years. time...
Ze względu na znaczne wydłużenie przeżycia chorych szpiczaka plazmocytowego (PCM) coraz częściej obserwuje się u nich występowanie innych nowotworów. Klasycznym przykładem jest rozwój wtórnych do zastosowanej wcześniej chemioterapii zespołów mielodysplastycznych (MDS). W niniejszej pracy opisano rzadki przypadek chorego, którego stwierdzono współistnienie PCM oraz MDS związanym z izolowaną del 5q– (MDS 5q–). Zastosowanie lenalidomidu pozwoliło uzyskanie częściowej remisji cytogenetycznej PCM.