A5019195568- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Oral health in cancer treatment
- Cytomegalovirus and herpesvirus research
- Acute Lymphoblastic Leukemia research
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- Hepatitis B Virus Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Histone Deacetylase Inhibitors Research
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Drug Transport and Resistance Mechanisms
- T-cell and Retrovirus Studies
- Mesenchymal stem cell research
- Herpesvirus Infections and Treatments
- Advancements in Materials Engineering
- Galectins and Cancer Biology
- Oral and gingival health research
Instytut Hematologii i Transfuzjologi
2013-2025
Institute of Haematology and Blood Transfusion
2010-2015
Institute for Transfusion Medicine
2015
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase that maintains genome stability by maintaining telomere length (TL). The massive proliferation donor cells in the recipient's body for engraftment results accelerated shortening. Genetic variability within TERT gene affects activity, and was shown to influence haematopoietic stem cell transplantation (HSCT) outcome. In present study, we aimed analyse effect recipient TL single nucleotide polymorphism (SNP) on...
Some cancers treated with allogeneic hematopoietic stem cell transplantation (HSCT) are sensitive to natural killer (NK) reactivity. NK function depends on activating and inhibitory receptors is modified by education/licensing effect mediated coexpression of killer-cell immunoglobulin-like receptor (KIR) its corresponding HLA I ligand. We assessed KIR (aKIR)-based I-dependent education capacity in donor NKs 285 patients hematological malignancies after HSCT from unrelated donors. found...
Among cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), some are sensitive to natural killer (NK) cell reactivity, described as the "missing self" recognition effect. However, this model disregarded NK licensing effect, which highly increases reactivity against tumor and is dependent on coexpression of inhibitory immunoglobulin-like receptor (iKIR) its corresponding HLA Class I ligand. We assessed clinical data, donor iKIR genotyping in 283 patients myelo-...
This report is a retrospective analysis of 65 patients with peripheral T cell lymphoma (PTCL), who underwent high-dose therapy and autologous hematopoietic stem transplantation (autoHCT) as consolidation first response achieved either induction or salvage chemotherapy. We intended to determine the prognostic factors that influenced outcome after autoHCT define predictive value scoring systems most often applied for transplant outcomes. Nineteen in complete partial remission Forty-six...
Palifermin is known as the effective growth factor to reduce incidence, duration and severity of oral mucositis (OM) following hematopoietic stem cell transplantation (HSCT). However, additional data on long-term safety palifermin its potential influence graft versus host disease (GvHD) are needed.In this multi-center, non-randomized, matched-control study we assessed early overall survival (OS), incidence acute/chronic GvHD (a/cGvHD) secondary malignancies in 36 patients with hematological...
HLA are functional in cancer immunosurveillance adaptive and innate immunity pathways. In unrelated hematopoietic stem cell transplantation (HSCT) 688 patients with hematological malignancies we compared antitumor efficacy of transplant three models including the level of: (a) donor‐recipient class I mismatch, (b) KIR‐ligand (c) post‐transplant cognate HLA:KIR pairing. The effects were directly multivariate backward elimination all initial model. final model mismatch levels eliminated...
Internal tandem duplication (ITD) of the FLT3 gene (Fms-like tyrosine kinase 3) is most commonly found mutation in acute myeloid leukemia (AML). The significance FLT3-ITD at diagnosis was retrospectively estimated for allo-HSCT (allogeneic hematopoietic stem cell transplantation) outcomes 140 patients, median age 38, undergoing after myeloablative conditioning first complete remission AML. detected AML 42/140 (30%) included into this study patients. At 3 years, relapse incidence (RI)...
Background:Graft-versus-host disease (GvHD) is the most important complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) responsible for increased mortality. Recent studies have discussed use of oral GvHD screening tests in diagnosis systemic GvHD. This first study significance labial biopsy hepatic graft-versus-host (H-GvHD) following allo-HSCT.Material/Methods:Twenty-one patients alloHSCT were selected: 12 with H-GvHD established clinically and laboratory tests,...
Viral infections are still a serious diagnostic and therapeutic problem in patients undergoing alternative donor transplants. β-Herpesviruses (especially human herpesvirus type 5, 6 7) recognized pathogens this group of may cause central nervous system disease. Guillain-Barré syndrome (GBS) is very rare complication among stem cell transplant recipients usually has been attributed to infection. We report case resolving simultaneous GBS HHV-6-associated encephalitis haematopoietic recipient...
Viral infections are the main cause of increased morbidity and mortality among recipients in allogeneic hematopoietic stem cell transplantation (HSCT). Natural killer (NK) cells fight virally infected provided directional activation cytotoxicity. In this study, we analyzed role receptor-ligand pairs that include inhibitory or activating immunoglobulin-like receptors (KIRs) with their HLA class I ligands course viral infections. The paper also presents an algorithm allows performing automated...
Transplantation of hematopoietic stem cells (HSCT) is a procedure commonly used in treatment various haematological disorders which associated with significantly improved survival rates. However, one its drawbacks the possibility development post-transplant complications, including acute and chronic graft-versus-host disease (GvHD) or CMV infection. Various studies suggested that NK their receptors may affect transplant outcome. In present study, patients donors were found to differ...