A5103129761- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Fungal Infections and Studies
- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Polyomavirus and related diseases
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Pneumonia and Respiratory Infections
- Childhood Cancer Survivors' Quality of Life
- Diabetes and associated disorders
- Autoimmune and Inflammatory Disorders Research
- Antibiotic Use and Resistance
- Acute Kidney Injury Research
- Ethics and Legal Issues in Pediatric Healthcare
- Blood transfusion and management
- Urinary Tract Infections Management
- Urticaria and Related Conditions
- Renal Transplantation Outcomes and Treatments
- Parvovirus B19 Infection Studies
- Antibiotics Pharmacokinetics and Efficacy
- Herpesvirus Infections and Treatments
Rzeszów University
2019-2024
Wroclaw Medical University
2009-2015
Szpital Kliniczny Nr 1 we Wrocławiu
2015
University of Wrocław
2011
Henry Ford Health System
2004
Lukasiewicz Research Network - Krakow Institute of Technology
1994
The aim of our study was to compare the results unrelated donor (UD) peripheral blood stem cell transplantation versus UD bone marrow and analyze impact infused CD34+ CD3+ doses on survival incidence severe graft-versus-host disease (GVHD) in 187 children who underwent hematopoietic with use vivo T depletion (antithymocyte globulin or CAMPATH-1H). HLA typing performed at "high-resolution" level. Patients receiving ≥10 × 106 cells/kg ≥4 108 had better overall disease-free survival....
Administration of contrast agents may result in an acute reduction renal function and occasionally end-stage disease. Risk factors for contrast-induced nephropathy (CN) are preexisting dysfunction, diabetes reduced effective arterial volume. Hydration use nonionic have been reported to ameliorate CN. Reactive oxygen species a role the pathogenesis Statins decrease free radicals animals. We retrospectively tested hypothesis that administering statins prior cardiac catheterization decreases...
Objectives: The analysis of epidemiology, risk factors and outcome infections in children with malignant bone tumors (MBT) undergoing chemotherapy. Methods: In this retrospective nationwide multicenter cross-sectional study, a total number 126 MBT including 70 Ewing sarcoma (ES) 56 osteosarcoma (OSA) were screened for over period 72 consecutive months. Results: infection was 7.15-fold higher patients ES as compared to the OSA group, especially concerning bacterial (4.1-fold increase risk)....
Background: Infectious complications (IC) caused by bacterial strains often impede anticancer therapy. The study aimed to retrospectively analyze IC that could help predict the risk and optimize empirical treatment for infections in pediatric cancer patients. Patients Methods: Over a 72-month period, all-in 5,599 children with cancer: 2,441 patients hematological malignancy (HM including acute leukemias, Hodgkin non-Hodgkin lymphomas [NHLs], Langerhans cell histiocytosis) 3,158 solid tumors...
The aim of this nationwide study was to describe the epidemiology and profile bacterial infections (BI), invasive fungal disease (IFD) viral (VI) in patients with de novo relapsed/refractory (rel/ref) acute myeloid leukemia (AML). Within studied group 250 children primary AML, at least one infectious complication (IC) diagnosed 76.0% (n = 190) including 85.1% 504) episodes BI, 8.3% 49) – IFD 6.6% 39) VI. Among 61 rel/ref IC found 67.2% 41) 78.8% 78) 14.1% 14) 7.1% 7) In all AML patients,...
Background: Infections caused by Stenotrophomonas maltophilia (SM) have documented high mortality rate in immunocompromised patients. Aim: This nationwide multicenter study was performed to analyze the epidemiology of SM infections children undergoing anticancer therapy (pediatric hematology and oncology [PHO]) or hematopoietic cell transplantation (HCT) over 2012–2019, including incidence outcome infections, as well treatment regimens multidrug resistance. Methods: Cumulative calculated...
Abstract Varicella‐zoster virus (VZV) infection in pediatric hemato‐oncology patients can be a therapeutic problem when children are exposed to immunosuppression. The aim of this study is evaluate the incidence VZV infection, antiviral therapy and outcome with ALL treated polish hemato‐oncological centers between 2012 2019 years. This included medical records 1874 patients, aged 1 18 years, newly diagnosed acute lymphoblastic leukemia. During chemotherapy, 406 out (21.6%) experienced viral...
Viral infections can be a serious complication of therapy in children with acute lymphoblastic leukemia (ALL). In this study, we focused on the incidence and profile viral infection ALL treated 17 pediatric oncology centers Poland two-year periods 2018-2019 2020-2021. We also compared frequency to that 2020-2021, total 192 had during intensive chemotherapy. A number 312 episodes were diagnosed. The most common detected samples were: COVID-19 (23%), rhinovirus (18%), respiratory syncytial...
Pediatric germ cell tumors (GCTs) are a group of chemosensitive malignancies with 90% curability rate. We report series children relapsing or therapy-resistant GCT treated melphalan–etoposide–carboplatin high-dose chemotherapy (HDCT) and autologous stem transplantation. This consisted 18 children, either GCTs after relapse (nine patients) an unsatisfactory response to first-line patients), who underwent HDCT. The HDCT regimens MEC1 (carboplatin 1500 mg/m2, etoposide 1800 melphalan 140 mg/m2)...
ABSTRACT Background Apheresis in children with low body weight is technically limited by their tolerance of the extracorporeal blood volume. Study design and methods This paper presents a single‐center experience 23 procedures 12 weights between 5.2 9.5 kg using Spectra Optia mononuclear cell (MNC) protocol priming. Results The average procedure duration was 158 minutes, median processed volume 316 mL/kg. white (WBC), platelet (PLT), hemoglobin (HGB) values showed downward trend increased...
Background: Klebsiella pneumoniae is a nosocomial pathogen that causes severe infections in immunocompromised patients. The aim of the study was to conduct microbiological and clinical analysis K. children with malignancies or undergoing hematopoietic cell transplantation Poland. Methods: We conducted retrospective, multicenter including adolescents under 19 years old treated between 2012 2021. analyzed patients’ characteristics, data, outcomes antibiotic therapy. Results: A total 9121 newly...
The most common complications related to the treatment of childhood acute lymphoblastic leukemia (ALL) are infections. aim study was analyze incidence and mortality rates among pediatric patients with ALL who were treated in 17 Polish hematology centers 2020-2021 during pandemic. Additionally, we compared these results those our previous study, which conducted years 2012-2017. retrospective analysis included 460 aged 1-18 newly diagnosed ALL. In 361/460 (78.5%) children reported have...
The mortality of allogeneic hematopoietic stem cell (allo-HSC) recipients transplanted with invasive fungal infection (IFI) is high due to the risk progression. Eleven (8 children and 3 adults) out 256 (4.3%) patients who underwent allo-HSCT from January 2005 August 2010 at Wroclaw Pediatric Transplant Center were diagnosed IFI, classified as possible (4), probable (2) or proven (5), median 40 days (11 - 60) prior allo-HSCT. In spite persistent transplant procedures not postponed advanced...
Treosulfan is an immuno-suppressive and myeloablative alkylating agent that has been introduced as a conditioning in hematopoietic stem cell transplantation (HSCT), mostly adults with malignancies. Recently published UK study on 32 children non- malignant disease showed excellent engraftment reduced regimen- related toxicity. We report the use of treosulfan 26 (median age 8.2, range 0.4–17.8; SAA n = 14, inborn errors 12, incl X-ALD 4, SCID 5, CGD 2 Griscelli S. 1) who underwent HSCT for...
There is an unresolved question whether unmanipulated matched unrelated donor (MUD) PBSCT leads to a worse overall outcome and higher incidence of severe GvHD in comparison with well established MUD-BMT. It known that PBSC grafts contain ca 1 log more mature T cells, which may result rate often fatal acute/chronic after MUD-PBSCT. The aim our study was compare the results MUD-PBSCT vs MUD-BMT large mostly pediatric patient population. We analyzed records 177 consecutive pts (with hematologic...