Wojciech Czogała
A5051508692- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Immunodeficiency and Autoimmune Disorders
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Polyomavirus and related diseases
- Antifungal resistance and susceptibility
- Growth Hormone and Insulin-like Growth Factors
- Fungal Infections and Studies
- Acute Myeloid Leukemia Research
- Hepatitis B Virus Studies
- Blood disorders and treatments
- Cellular Mechanics and Interactions
- Lipid metabolism and disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pediatric health and respiratory diseases
- Apelin-related biomedical research
- Cell Adhesion Molecules Research
- Genetic Syndromes and Imprinting
- Cystic Fibrosis Research Advances
- Viral Infections and Vectors
- Skin and Cellular Biology Research
- PARP inhibition in cancer therapy
- Quinazolinone synthesis and applications
- Polish Legal and Social Issues
Jagiellonian University
2005-2024
University School of Physical Education in Kraków
2021-2023
Uniwersytecki Szpital Dziecięcy
2007-2022
Cracow University of Technology
2016
CD40 ligand (CD40L) deficiency, an X-linked primary immunodeficiency, causes recurrent sinopulmonary, Pneumocystis and Cryptosporidium species infections. Long-term survival with supportive therapy is poor. Currently, the only curative treatment hematopoietic stem cell transplantation (HSCT).We performed international collaborative study to improve patients' management, aiming individualize risk factors determine optimal HSCT characteristics.We retrospectively collected data on 130 patients...
The occurrence of childhood obesity is influenced by both genetic and epigenetic factors. FTO (FTO alpha-ketoglutarate dependent dioxygenase) a gene well-established connection with adiposity, while protooncogene PLAG1 (PLAG1 zinc finger) has been only recently linked to this condition. We performed cross-sectional study on cohort 16 obese (aged 6.6–17.7) 10 healthy 11.4–16.9) children. aim was evaluate the relationship between methylation expression aforementioned genes presence as well...
Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation differentiation may be of importance in obesity development. The aim the study was to analyze expression chosen IGF-axis genes concentration their protein products 28 obese children (OB) 34 healthy control (HC), correlation with essential parameters associated childhood obesity. gene IGFBP7 higher, IGF2 IGFBP1 lower OB. IGFBP6 tended IGFBP4 significantly IGFBP3 higher OB...
Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed results of AML treatment Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering treated with following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, 74), 98 (1998–2004, 151), AML-BFM 2004...
Acute P./myeloid leukemia post cytotoxic therapy (AML-pCT) is rare complication of cancer treatment in childhood. The objective the study was to identify clinical characteristics and provide an analysis outcomes pediatric AML-pCT. We retrospectively analyzed data 40 children with AML-pCT, treated from 2005 2020 within Polish Pediatric Leukemia Lymphoma Study Group. most common primary malignancies were acute lymphoblastic (32.5%) brain tumors (20%). median latency period 2.9 years (range:...
Chronic granulomatous disease (CGD) is phagocytic cell metabolic disorder resulting in recurrent infections and granuloma formation. This paper reports the favourable outcome of allogeneic transplantation six high-risk CGD patients. The following donors were used: HLA-matched, related (two) unrelated (three), HLA-mismatched, (one). One patient was transplanted twice using same sibling donor because graft rejection at 6 months after reduced-intensity conditioning transplant (fludarabine...
Visfatin (VF) is an adipocytokine that performs many functions, including enhancing cell proliferation and biosynthesis of nicotinamide mononucleotides dinucleotides. It also seems to be involved in the development glucose metabolism disturbances. The goal study was determination VF concentrations children with leukemia who are treated stem transplantation. were measured plasma before after oral tolerance test (OGTT; 60 120 minutes) 22 hematopoietic transplantation (HSCT) healthy control...
Adipokines and gastrointestinal tract hormones are important metabolic parameters, both epigenetic factors differential gene expression patterns may be associated with the alterations in their concentrations children. The function of FTO (FTO alpha-ketoglutarate dependent dioxygenase) regulation global rate is well described, whereas influence protooncogene PLAG1 (PLAG1 zinc finger) still not fully understood. A cross-sectional study on a group 26 children various BMI values (15.3-41.7;...
Viral infections can be a serious complication of therapy in children with acute lymphoblastic leukemia (ALL). In this study, we focused on the incidence and profile viral infection ALL treated 17 pediatric oncology centers Poland two-year periods 2018-2019 2020-2021. We also compared frequency to that 2020-2021, total 192 had during intensive chemotherapy. A number 312 episodes were diagnosed. The most common detected samples were: COVID-19 (23%), rhinovirus (18%), respiratory syncytial...
Abstract: OS is a variant of SCID characterized by generalized erythroderma, alopecia, eosinophilia, and elevated IgE levels. It fatal unless treated with allogeneic HSCT, which the only curative approach. However, treatment related complications graft rejection are major obstacles to success treatment. In this report, we describe patient OS, complicated prolonged cytomegalovirus infection, successfully reduced intensity conditioning HSCT from sibling donor.
Metabolic disorders in children after hematopoietic stem cell transplantation (HSCT) are poorly characterized. However, it is known that dyslipidemia and insulin resistance particularly common these patients. We conducted a prospective study of 27 patients treated with HSCT to assess the possibility predicting abnormalities. measured gene expressions using microarray technique identify differences expression genes associated lipid metabolism before HSCT. In HSCT, total cholesterol levels...
Background: The FMS-like tyrosine kinase 3 (FLT3) gene mutated in 10–15% of pediatric acute myeloid leukemia (AML) is associated with an inferior outcome. aim the study was to analyze outcome and characteristics FLT3-ITD-positive AML. Methods: We retrospectively analyzed nationwide AML database from between 2005 2022. FLT3-ITD found 54/497 (10.7%) patients available analysis. Three consecutive treatment protocols were used (AML-BFM 2004 Interim, AML-BFM 2012 Registry, 2019 recommendations)....
Background: Klebsiella pneumoniae is a nosocomial pathogen that causes severe infections in immunocompromised patients. The aim of the study was to conduct microbiological and clinical analysis K. children with malignancies or undergoing hematopoietic cell transplantation Poland. Methods: We conducted retrospective, multicenter including adolescents under 19 years old treated between 2012 2021. analyzed patients’ characteristics, data, outcomes antibiotic therapy. Results: A total 9121 newly...
The most common complications related to the treatment of childhood acute lymphoblastic leukemia (ALL) are infections. aim study was analyze incidence and mortality rates among pediatric patients with ALL who were treated in 17 Polish hematology centers 2020-2021 during pandemic. Additionally, we compared these results those our previous study, which conducted years 2012-2017. retrospective analysis included 460 aged 1-18 newly diagnosed ALL. In 361/460 (78.5%) children reported have...
Infections in immunocompromised patients after hematopoietic stem cell transplantation can have a severe and atypical course. Some opportunistic pathogens are difficult to detect microbiological tests, that is why treatment success depends on an accurate clinical diagnosis. This article presents case of 7-year-old girl with aplastic anemia treated bone marrow post-transplantation period complicated by persistent, hectic fever, peak episodes 39-40°C, lasting several weeks. Repeated tests...
Insulin-like growth factors (IGF-1 and IGF-2) insulin-like factor-binding proteins (IGFBP-1 to -7) are involved in the regulation of cell proliferation differentiation may be associated with various metabolic parameters. The aim our study was compare levels IGFs IGFBPs expressions their genes children before after hematopoietic stem transplantation (HSCT) assess potential as markers late complications HSCT. We also conducted additional comparisons healthy controls correlations IGF IGFBP...