A5071491448- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Neuroendocrine Tumor Research Advances
- Cancer-related cognitive impairment studies
- Pancreatic function and diabetes
- Fibroblast Growth Factor Research
- Genetic and phenotypic traits in livestock
- Ruminant Nutrition and Digestive Physiology
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Analog and Mixed-Signal Circuit Design
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Adolescent and Pediatric Healthcare
- Erythrocyte Function and Pathophysiology
- Hearing, Cochlea, Tinnitus, Genetics
- Chronic Myeloid Leukemia Treatments
- MicroRNA in disease regulation
- School Health and Nursing Education
- Artificial Intelligence in Games
- Cancer Genomics and Diagnostics
- Blood disorders and treatments
- Nuts composition and effects
- Immunodeficiency and Autoimmune Disorders
Jagiellonian University
2010-2024
Uniwersytecki Szpital Dziecięcy
2017-2021
Warsaw University of Life Sciences
2009
Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism genes encoding proteins engaged in folate metabolism pathway. aim current study to determine relationship between variants metabolism-related frequency toxicities HD-Mtx. Material Methods: A group 133 aged 1.5-18.1 years (median: 6.3) was treated accordance with ALL-IC-2002...
The aim of the following case report is to provide a description acute lymphoblastic leukemia (ALL) in patient with Netherton syndrome (NS). A 15-years-old male NS was referred suspicion leukemia. Severe anemia, leukocytosis, thrombocytopenia and elevated CRP level were demonstrated pre-hospital laboratory tests. Physical examination revealed generalized ichthyosiform erythroderma. ALL diagnosed on basis bone marrow biopsy. initially classified as CNS3 status. No signals indicating fusion...
Abstract Minimal residual disease (MRD) enables reliable assessment of risk in acute lymphoblastic leukemia (ALL). However, little is known on association between MRD status and germline genetic variation. We examined 159 Caucasian (Slavic) patients with pediatric ALL, treated according to ALL-IC-BFM 2002/2009 protocols, search for 23 polymorphisms at day 15, 33 week 12, adjustment MRD-associated clinical covariates. Three variants were significantly associated MRD: rs1544410 VDR...
Metabolic disorders in children after hematopoietic stem cell transplantation (HSCT) are poorly characterized. However, it is known that dyslipidemia and insulin resistance particularly common these patients. We conducted a prospective study of 27 patients treated with HSCT to assess the possibility predicting abnormalities. measured gene expressions using microarray technique identify differences expression genes associated lipid metabolism before HSCT. In HSCT, total cholesterol levels...
Modern treatment of childhood acute lymphoblastic leukemia (ALL) has resulted in a high cure rate; however, it can cause central nervous system toxicity. In the present study, group 136 ALL survivors were screened for changes P300. Therapy was conducted according to modified New York (NY) protocol (30 patients) and two subsequent revisions Berlin-Frankfurt-Münster (BFM) (32 74 patients). The control consisted 58 patients. had significantly prolonged mean latency P300 (331.31±28.71 vs....
Children with Down syndrome (DS) have a 20-fold increased risk of developing leukemia compared the general population. The aim study was to analyze outcome patients diagnosed and acute lymphoblastic (ALL) in Poland between years 2003 2010. A total 1848 children were ALL (810 females 1038 males). Of those, 41 (2.2%) had DS. classified into three groups: standard-risk group—14 patients, an intermediate-risk group—24, high-risk group—3. All treated according ALLIC 2002 protocol. median...
It has been shown that approximately half of survivors childhood acute lymphoblastic leukemia (ALL) have symptomatic late effects (LE) may be severe or life-threatening. The aim our study was to assess the health status ALL after over 10 years follow-up and its relationships with gene polymorphisms, numbers types LEs, as well intensity chemotherapy cranial radiotherapy (CRT). We conducted a telephone survey in 125 (median time from completion treatment 12 years) compared results those...
Modern treatment in childhood acute lymphoblastic leukemia (ALL) resulted high cure rate. However, it causes central nervous system toxicity. A group of 136 ALL survivors were screened for P300 potentials changes. Therapy was conducted according to modified New York (NY - 30 patients) and two subsequent revisions Berlin-Frankfurt-Münster (BFM 32 74 patients). The control consisted 58 patients. had significantly prolonged the mean latency (331.31+/-28.71 vs 298.14+/-38.76 ms, P<0.001)...
Abstract Background Gastrointestinal tract function and it’s integrity are controlled by a number of peptides whose secretion is influenced severe inflammation. In stomach the main regulatory peptide ghrelin. For upper small intestine cholecystokinin lower glucagon-like peptide- 1 secreted, while fibroblast growth factor-21 secreted several organs, including liver, pancreas, adipose tissue [12]. Hematopoietic stem cell transplantation causes serious mucosal damage, which can reflect on this...
Abstract Background One of the greatest success pediatric hematology is a prominent improvement survival in acute lymphoblastic leukemia (ALL ). Therefore , special attention needs to be paid long-term side effects treatment such as neurotoxicity. few diagnostic methods that allow an objective assessment sensory systems are evoked potentials (EP). Methods The analyzed group consisted 167 ALL survivors, aged 4.9–28.4 years, without auditory, visual and deviations. Patients were treated with...
Abstract Background: Gastrointestinal tract function and it's integrity are controlled by a number of peptides whose secretion is influenced severe inflammation. In stomach the main regulatory peptide ghrelin. For upper small intestine cholecystokinin lower glucagon-like peptide- 1 secreted, while fibroblast growth factor-21 secreted several organs, including liver, pancreas, adipose tissue [12]. Hematopoietic stem cell transplantation causes serious mucosal damage, which can reflect on this...
Hypertension is a well-known late effect of hematopoietic cell transplantation (HCT), but no markers predicting its development are known. Our aim was to assess short-term blood pressure (BP) values and expressions hypertension-associated genes as possible hypertension in children treated with HCT. We measured systolic (SBP) diastolic (DBP), using both office procedure ambulatory BP monitoring (ABPM) before HCT after median 6 months compared the results two control groups, one healthy...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kwiecińska K, Strojny W, Pietrys D, Balwierz Skoczeń S. Is physician needed for a patient cured of malignancy in childhood?. Psychoonkologia. 2017;21(4):157-160. doi:10.5114/pson.2017.77550. APA Kwiecińska, K., Strojny, W., Pietrys, D., Balwierz, & Skoczeń, (2017). Psychoonkologia, 21(4), 157-160. https://doi.org/10.5114/pson.2017.77550 Chicago Kinga, Wojciech Danuta Walentyna and Szymon Skoczeń. 2017. "Is...
Abstract Gastrointestinal tract function and it's integrity are controlled by a number of peptides whose secretion is influenced severe inflammation. In stomach the main regulatory peptide ghrelin. For upper small intestine cholecystokinin glucagon-like peptide- 1 secreted, while fibroblast growth factor-21 secreted several organs, including liver, pancreas, adipose tissue [12]. Hematopoietic stem cell transplantation causes serious mucosal damage, which can reflect on this peptides. The aim...
Reconstitution of cell lines and occurrence complications following hematopoietic stem transplantation (HSCT) are regulated by genome expression.Microarray technique allows for simultaneous assessment expression nearly all human genes.The objective the study was to compare whole in children before after HSCT.A total 44 treated with HSCT were enrolled study.Gene measured (pre-HSCT group; n=44) a median 6 months allogenic (post-HSCT n=27; included pre-HSCT group).Neoplasms indication 73%...
Abstract Background: Gastrointestinal tract function and it's integrity are controlled by a number of peptides whose secretion is influenced severe inflammation. In stomach the main regulatory peptide ghrelin. For upper small intestine cholecystokinin lower glucagon-like peptide- 1 secreted, while fibroblast growth factor-21 secreted several organs, including liver, pancreas, adipose tissue [12]. Hematopoietic stem cell transplantation causes serious mucosal damage, which can reflect on this...