A5067782930- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Neutropenia and Cancer Infections
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Hematological disorders and diagnostics
- Pancreatitis Pathology and Treatment
- Antifungal resistance and susceptibility
- Retinoids in leukemia and cellular processes
- Fungal Infections and Studies
- Thyroid Disorders and Treatments
- Pediatric health and respiratory diseases
- Lymphoma Diagnosis and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cystic Fibrosis Research Advances
- Sarcoma Diagnosis and Treatment
- Polish Law and Legal System
- Folate and B Vitamins Research
- PI3K/AKT/mTOR signaling in cancer
- Polyomavirus and related diseases
Jagiellonian University
2006-2024
Uniwersytecki Szpital Dziecięcy
2017-2024
University School of Physical Education in Kraków
2021-2023
Palmetto Hematology Oncology
2017
The occurrence of childhood obesity is influenced by both genetic and epigenetic factors. FTO (FTO alpha-ketoglutarate dependent dioxygenase) a gene well-established connection with adiposity, while protooncogene PLAG1 (PLAG1 zinc finger) has been only recently linked to this condition. We performed cross-sectional study on cohort 16 obese (aged 6.6–17.7) 10 healthy 11.4–16.9) children. aim was evaluate the relationship between methylation expression aforementioned genes presence as well...
Papillary thyroid carcinoma (PTC) often coincides with autoimmune thyroiditis (AIT); whether this association is incidental or causal remains debated.To evaluate the ultrasonographic, laboratory, and histopathological features of PTC in paediatric patients without AIT its relationship to puberty.A retrospective cohort study.A analysis medical records 90 (69; 76.7% females). The mean age at diagnosis was 13.8 years [range 6-18]. All were evaluated ultrasonographically before surgery. Thyroid...
Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism genes encoding proteins engaged in folate metabolism pathway. aim current study to determine relationship between variants metabolism-related frequency toxicities HD-Mtx. Material Methods: A group 133 aged 1.5-18.1 years (median: 6.3) was treated accordance with ALL-IC-2002...
Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed results of AML treatment Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering treated with following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, 74), 98 (1998–2004, 151), AML-BFM 2004...
Since 1983 four consecutive unified regimens: acute myeloid leukemia-Polish pediatric leukemia/lymphoma study group (AML-PPLLSG) 83, AML-PPLLSG 94, 98 and AML-BFM 2004 Interim, for AML have been conducted by the Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG). In this paper, we review successive studies on basis of leukemia-Berlin-Frankfurt-Munster (AML-BFM) protocol, in which a stepwise improvement treatment outcome was observed. Treatment results last protocol Interim are presented...
Neuroblastoma (NBL) is one of the most common extracranial tumours occurring in children with N-Myc gene amplification, acknowledged as a marker poor prognosis. We assessed frequency amplification and its impact on NBL markers treatment outcome.Among 160 treated from 1991 to 2015 centre 140 patients had known status, they were enrolled study. The analysed group was divided into two subgroups: without (25 115 children, respectively). Association stage disease, levels biochemical parameters,...
Acute P./myeloid leukemia post cytotoxic therapy (AML-pCT) is rare complication of cancer treatment in childhood. The objective the study was to identify clinical characteristics and provide an analysis outcomes pediatric AML-pCT. We retrospectively analyzed data 40 children with AML-pCT, treated from 2005 2020 within Polish Pediatric Leukemia Lymphoma Study Group. most common primary malignancies were acute lymphoblastic (32.5%) brain tumors (20%). median latency period 2.9 years (range:...
Myeloid sarcoma (MS) is an extramedullary malignant tumor composed of immature myeloid cells. It occurs in patients with acute leukemia (AML), myelodysplastic syndrome (MDS), or chronic (CML). MS may coincide disease diagnosis precede bone marrow involvement by months even years; it can also represent the manifestation a relapse (1, 2).The aim this study to describe clinical characteristics children diagnosed Poland as well analyze diagnostic methods, treatment, and outcomes including...
L-asparaginase (ASP) is widely used in the treatment of acute lymphoblastic leukemia (ALL) children. Monitoring its activity necessary because risk drug inactivation as result an immune reaction. Besides allergic reactions, another frequent side effect ASP coagulopathy, especially deficiency antithrombin III (ATIII). The aim this study was to analyze relationship between and ATIII activities possibility use indirect assessment. measured 76 children with ALL treated according IC BFM 2002...
Background: The reports of studies that compare the survival adolescents and young adults with younger children acute myeloid leukemia (AML) are contradictory. Patients Methods: We retrospectively analyzed 220 AML patients aged 0–18 years treated in pediatric oncologic centers Poland from 2015 to 2022. evaluated group included 31 infants (below 1 year), 91 (1–9.9 years), 59 older (10–14.9 39 (15–18 years). Results: A 5-year overall for was not significantly inferior compared (74.3 ± 7.6% vs....
Purpose: This study aimed to identify the risk factors for acute pancreatitis (AP) and its impact on outcomes in Polish children treated ALL. Methods: The group included 2303 who received intensive chemotherapy was subdivided into patients with at least one episode of AP those did not develop following treatment Results: cumulative incidence 4.08%. Older age an independent factor development (OR 1.05; 95%CI: 1.006 – 1.098; p=0.03). overall mortality related 2.13%. probabilities disease-free...
L-asparaginase (ASP) is an enzyme used as one of the basic regimens in acute lymphoblastic leukemia (ALL) therapy. Because possibility inactivation by antibodies, monitoring ASP activity essential. The aim study was to examine if plasma concentration ammonia, a direct product reaction catalyzed ASP, can be assessment activity. A group 87 patients with treated Department Pediatric Oncology and Hematology Krakow enrolled study. ammonia were measured after administrations during induction....
Background: Children with Down syndrome (DS) have increased risk of myeloid leukemia, but specific treatment protocols ensure excellent outcome. The aim the study was retrospective analysis results and genetic characteristics leukemia (ML-DS) in Poland from 2005 to 2019. Methods: All 54 patients ML-DS registered Polish Pediatric Leukemia Lymphoma Study Group analyzed period were enrolled study. There 34 children treated AML-BFM 2004 Interim protocol (group I) 20 2006 II). In first there...
11q23/MLL rearrangements are frequently detected in pediatric acute myeloid leukemia. The analysis of their clinical significance is difficult due to the multitude translocation fusion partners and low frequency. presence t(10;11)(p12;q23) was previously identified AML. It considered as second most common 11q23/MLL-rearranged (present KMT2A) AML, after t(9;11)(p22;q23). above an unfavorable prognostic factor. Since June 2015 Polish Pediatric Leukemia/Lymphoma Study Group has applied...
Metabolic disorders in children after hematopoietic stem cell transplantation (HSCT) are poorly characterized. However, it is known that dyslipidemia and insulin resistance particularly common these patients. We conducted a prospective study of 27 patients treated with HSCT to assess the possibility predicting abnormalities. measured gene expressions using microarray technique identify differences expression genes associated lipid metabolism before HSCT. In HSCT, total cholesterol levels...
Background: The FMS-like tyrosine kinase 3 (FLT3) gene mutated in 10–15% of pediatric acute myeloid leukemia (AML) is associated with an inferior outcome. aim the study was to analyze outcome and characteristics FLT3-ITD-positive AML. Methods: We retrospectively analyzed nationwide AML database from between 2005 2022. FLT3-ITD found 54/497 (10.7%) patients available analysis. Three consecutive treatment protocols were used (AML-BFM 2004 Interim, AML-BFM 2012 Registry, 2019 recommendations)....
Background Gemtuzumab ozogamicin (GO), one of the first targeted drugs used in oncology, consists an anti-cluster differentiation 33 (CD33) monoclonal antibody bound to a derivative cytotoxic calicheamicin. After drug withdrawn 2010 due significantly higher rate early deaths, GO regained approval 2017 for treatment newly diagnosed, refractory, or relapsed acute myeloid leukemia (AML) adults and children over 15 years age. The objective study was retrospective analysis clinical...
Abstract Hypodiploidy, defined as modal numbers (MNs) 45 or lower, has not been independently investigated in pediatric acute myeloid leukemia (AML) but is a well-described high-risk factor lymphoblastic leukemia. We aimed to characterize and study the prognostic impact of hypodiploidy AML. In this retrospective cohort study, we included children below 18 years age with de novo AML hypodiploid karyotype diagnosed from 2000 2015 14 childhood groups International Berlin-Frankfurt-Münster...
Background: The aim of the study was to analyze treatment outcome and genetic characteristics acute promyelocytic leukemia (APL) in children Poland from 2005 2018. Methods: All 41 patients diagnosed with APL during analysis period were eligible for study. In I (2005-2015), 33 treated chemotherapy all-trans retinoic acid (ATRA), II (2015-2018), 3 (high risk) received induction ATRA arsenic trioxide (ATO), 5 (standard ATO without chemotherapy. Results: Probability 5-years overall survival...
Background
 Ultrasonographic measurement of the optic nerve sheath diameter (ONSD) is helpful in assessment intracranial pressure. The aim this study was to determine whether Trendelenburg position during laparoscopic urological surgery changed ONSD and changes correlated with postoperative complications.
 Methods 
 In prospective study, we measured before patients were placed position. Then established by tilting operating table 20-25 degrees. After surgery, a horizontal...