A5028015453- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Neuroblastoma Research and Treatments
- Cancer-related cognitive impairment studies
- Glioma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Regulation of Appetite and Obesity
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Chronic Lymphocytic Leukemia Research
- Diet and metabolism studies
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
- Lipid metabolism and disorders
- Apelin-related biomedical research
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Fibroblast Growth Factor Research
- Analog and Mixed-Signal Circuit Design
- Birth, Development, and Health
- Folate and B Vitamins Research
- Growth Hormone and Insulin-like Growth Factors
Jagiellonian University
2016-2025
Uniwersytecki Szpital Dziecięcy
2011-2024
University School of Physical Education in Kraków
2021-2023
GTx (United States)
2017
Boston Children's Hospital
1997-2015
Weatherford College
2009
University of California, San Francisco
2003
Nicolaus Copernicus University
1994
Relatively little is known about how to use the Internet promote health behavioral change. This article describes a multiple-contact smoking cessation program with an 8-week web-based course, online tools for self-monitoring of behaviors, and computer-tailored e-mail messages timed enrollees' quit efforts. In pilot study in 49 smokers, we found that enrollees returned website median 2 times completed average 8 educational modules. follow-up, respondents (n = 26) rated web components...
Abstract Acute lymphoblastic leukemia expressing the gamma delta T-cell receptor (γδ T-ALL) is a poorly understood disease. We studied 200 children with γδ T-ALL from 13 clinical study groups to understand and genetic features of this found age drivers were significantly associated outcome. diagnosed in under 3 years was extremely high-risk enriched for alterations that result both LMO2 activation STAG2 inactivation. Mechanistically, using patient samples isogenic cell lines, we show...
During cancer treatment, nutritional status disorders such as malnutrition or obesity affect the tolerance of quality life, but also pharmacokinetics drugs. It is hypothesized that changes in fat and lean body mass can modify chemotherapy volume distribution, metabolism clearance. In children with cancer, decreases remains low during treatment increases. Body composition influenced by itself, aggressive multimodal-therapies, metabolism, unbalanced diet reduced physical activity. Due to side...
The occurrence of childhood obesity is influenced by both genetic and epigenetic factors. FTO (FTO alpha-ketoglutarate dependent dioxygenase) a gene well-established connection with adiposity, while protooncogene PLAG1 (PLAG1 zinc finger) has been only recently linked to this condition. We performed cross-sectional study on cohort 16 obese (aged 6.6–17.7) 10 healthy 11.4–16.9) children. aim was evaluate the relationship between methylation expression aforementioned genes presence as well...
Insulin-like growth factors (IGFs) and insulin-like growth-factor-binding proteins (IGFBPs) regulate cell proliferation differentiation may be of importance in obesity development. The aim the study was to analyze expression chosen IGF-axis genes concentration their protein products 28 obese children (OB) 34 healthy control (HC), correlation with essential parameters associated childhood obesity. gene IGFBP7 higher, IGF2 IGFBP1 lower OB. IGFBP6 tended IGFBP4 significantly IGFBP3 higher OB...
Despite the progress that has been made in recent decades treatment of pediatric acute leukemias, e.g., converting lymphoblastic leukemia (ALL) from a fatal to highly curable disease, 15-20% children still relapse. Blinatumomab, bispecific CD3/CD19 antibody construct, successfully used relapsed/refractory r/r B-cell precursor ALL (BCP-ALL) as bridge hematopoietic stem cell transplantation (HSCT). We retrospectively assessed efficacy and toxicity blinatumomab 13 with BCP-ALL. Between 2017...
Background: Acinetobacter, significantly A.baumannii, are becoming a great threat to hospitalized patients due increasing antibiotic resistance. The aim of this study was describe the epidemiology, clinical characteristic, antimicrobial susceptibility pattern and outcome Acinetobacter infections in pediatric cancer HSCT recipients Poland. Methods: total 125 episodes species were reported pa-tients < 18 years treated Polish hematology oncology centers over pe-riod from 2012 2023....
PURPOSE Soon after the Russian invasion of Ukraine in February 2022, an initiative was organized to evacuate Ukrainian children with cancer, most initially Poland. This study assessed impact this rapid increase clinical need on Polish system pediatric cancer care. METHODS multicenter longitudinal approach performed among all 19 Pediatric Oncology Centers (PPOCs). We compared PPOC capacity before that during first 11 weeks invasion, using three ratios: patients physicians (PtP), nurses (PtN),...
Approximately 20% of children and adolescents in Europe are overweight. Survivors pediatric acute lymphoblastic leukemia (ALL) at increased risk overweight obesity. The purpose this study was to assess leptin soluble receptor levels, as well polymorphisms selected genes survivors ALL, the influence chemo- radiotherapy on development context regulation. Eighty two patients (55% males), median age 13.2 years (m: 4.8 years; M: 26.2 years) were included study. ALL therapy conducted according...
Introduction: High dose methotrexate (HD-Mtx) is highly effective and significantly improves overall acute lymphoblastic leukemia (ALL) patients survival. The pharmacodynamics of Mtx depends on the polymorphism genes encoding proteins engaged in folate metabolism pathway. aim current study to determine relationship between variants metabolism-related frequency toxicities HD-Mtx. Material Methods: A group 133 aged 1.5-18.1 years (median: 6.3) was treated accordance with ALL-IC-2002...
The aim of the following case report is to provide a description acute lymphoblastic leukemia (ALL) in patient with Netherton syndrome (NS). A 15-years-old male NS was referred suspicion leukemia. Severe anemia, leukocytosis, thrombocytopenia and elevated CRP level were demonstrated pre-hospital laboratory tests. Physical examination revealed generalized ichthyosiform erythroderma. ALL diagnosed on basis bone marrow biopsy. initially classified as CNS3 status. No signals indicating fusion...
Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed results of AML treatment Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering treated with following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, 74), 98 (1998–2004, 151), AML-BFM 2004...
The presence of metabolically important genetic polymorphisms may affect treatment efficacy in patients with malignancies. objective this prospective multicenter study was to evaluate the role selected genes associated metabolism chemotherapeutic drugs as prognostic markers children acute lymphoblastic leukemia.Genotyping for 7 variants 403 and analysis death cases were performed.Thirty-one died before reaching remission maintenance phase. Genetic revealed group increased frequency...
Chronic granulomatous disease (CGD) is phagocytic cell metabolic disorder resulting in recurrent infections and granuloma formation. This paper reports the favourable outcome of allogeneic transplantation six high-risk CGD patients. The following donors were used: HLA-matched, related (two) unrelated (three), HLA-mismatched, (one). One patient was transplanted twice using same sibling donor because graft rejection at 6 months after reduced-intensity conditioning transplant (fludarabine...
Acute P./myeloid leukemia post cytotoxic therapy (AML-pCT) is rare complication of cancer treatment in childhood. The objective the study was to identify clinical characteristics and provide an analysis outcomes pediatric AML-pCT. We retrospectively analyzed data 40 children with AML-pCT, treated from 2005 2020 within Polish Pediatric Leukemia Lymphoma Study Group. most common primary malignancies were acute lymphoblastic (32.5%) brain tumors (20%). median latency period 2.9 years (range:...
Visfatin (VF) is an adipocytokine that performs many functions, including enhancing cell proliferation and biosynthesis of nicotinamide mononucleotides dinucleotides. It also seems to be involved in the development glucose metabolism disturbances. The goal study was determination VF concentrations children with leukemia who are treated stem transplantation. were measured plasma before after oral tolerance test (OGTT; 60 120 minutes) 22 hematopoietic transplantation (HSCT) healthy control...
Background: The reports of studies that compare the survival adolescents and young adults with younger children acute myeloid leukemia (AML) are contradictory. Patients Methods: We retrospectively analyzed 220 AML patients aged 0–18 years treated in pediatric oncologic centers Poland from 2015 to 2022. evaluated group included 31 infants (below 1 year), 91 (1–9.9 years), 59 older (10–14.9 39 (15–18 years). Results: A 5-year overall for was not significantly inferior compared (74.3 ± 7.6% vs....