Walentyna Balwierz
A5040158837- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Multiple and Secondary Primary Cancers
- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Immunodeficiency and Autoimmune Disorders
- Neuroendocrine Tumor Research Advances
- Chronic Myeloid Leukemia Treatments
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Testicular diseases and treatments
- Hematological disorders and diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Sarcoma Diagnosis and Treatment
- Pharmaceutical studies and practices
- Genetic factors in colorectal cancer
- Ocular Oncology and Treatments
- Antifungal resistance and susceptibility
Jagiellonian University
2016-2025
Uniwersytecki Szpital Dziecięcy
2012-2024
University School of Physical Education in Kraków
1993-2023
Ghent University Hospital
2023
Rambam Health Care Campus
2023
Barmherzige Schwestern Krankenhaus Wien
2023
Poznan University of Medical Sciences
2018
Medical University of Lublin
2018
Centrum Onkologii
2010-2017
Children's Clinical University Hospital
2017
Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across world are diagnosed late. To our knowledge, clinical presentation retinoblastoma has never been assessed on global scale. report stage at in patients during single year, to investigate associations between variables national income level, risk factors for advanced disease diagnosis. A total 278 treatment centers were...
To evaluate the impact of surgeon-assessed extent primary tumor resection on local progression and survival in patients International Society Pediatric Oncology Europe Neuroblastoma Group High-Risk 1 trial.Patients recruited between 2002 2015 with stage 4 disease > year or 4/4S MYCN amplification < who had completed induction without progression, achieved response criteria for high-dose therapy (HDT), no before were included. Data collected excision, severe operative complications, outcome.A...
To reduce the incidence of febrile neutropenia during rapid COJEC (cisplatin, vincristine, carboplatin, etoposide, and cyclophosphamide given in a delivery schedule) induction. In High-Risk Neuroblastoma-1 (HR-NBL1) trial, International Society Paediatric Oncology European Neuroblastoma Group (SIOPEN) randomly assigned patients to primary prophylactic (PP) versus symptom-triggered granulocyte colony-stimulating factor (GCSF; filgrastim).From May 2002 November 2005, 239 16 countries were...
This retrospective cohort study aimed to determine the predictive relevance of clinical characteristics, additional cytogenetic aberrations, and cKIT RAS mutations, as well evaluate whether specific treatment elements were associated with outcomes in pediatric t(8;21)-positive patients acute myeloid leukemia (AML).Karyotypes 916 t(8;21)-AML reviewed for presence 228 samples screened mutations. Multivariable regression models used assess anthracyclines, cytarabine, etoposide during induction...
In neuroblastoma (NB), the ALK receptor tyrosine kinase can be constitutively activated through activating point mutations or genomic amplification. We studied genetic alterations in high-risk (HR) patients on HR-NBL1/SIOPEN trial to determine their frequency, correlation with clinical parameters, and prognostic impact.Diagnostic tumor samples were available from 1,092 amplification status (n = 330), mutational profile 191), both 571).Genomic (ALKa) was detected 4.5% of cases (41 out 901),...
Induction therapy is a critical component of the high-risk neuroblastoma. We aimed to assess if Memorial Sloan Kettering Cancer Center (MSKCC) N5 induction regimen (MSKCC-N5) would improve metastatic complete response (mCR) rate and 3-year event-free survival (EFS) compared with rapid COJEC (rCOJEC; cisplatin [C], vincristine [O], carboplatin [J], etoposide [E], cyclophosphamide [C]).
Children with Down syndrome (DS) are at a significantly higher risk of developing acute myeloid leukemia, also termed leukemia associated DS (ML-DS). In contrast to the highly favorable prognosis primary ML-DS, limited data that available for children who relapse or have refractory ML-DS (r/r ML-DS) suggest dismal prognosis. There few clinical trials and no standardized treatment approach this population. We conducted retrospective analysis international study groups pediatric oncology...
PURPOSE Soon after the Russian invasion of Ukraine in February 2022, an initiative was organized to evacuate Ukrainian children with cancer, most initially Poland. This study assessed impact this rapid increase clinical need on Polish system pediatric cancer care. METHODS multicenter longitudinal approach performed among all 19 Pediatric Oncology Centers (PPOCs). We compared PPOC capacity before that during first 11 weeks invasion, using three ratios: patients physicians (PtP), nurses (PtN),...
Background: Acinetobacter, significantly A.baumannii, are becoming a great threat to hospitalized patients due increasing antibiotic resistance. The aim of this study was describe the epidemiology, clinical characteristic, antimicrobial susceptibility pattern and outcome Acinetobacter infections in pediatric cancer HSCT recipients Poland. Methods: total 125 episodes species were reported pa-tients &lt; 18 years treated Polish hematology oncology centers over pe-riod from 2012 2023....
2 The full, final text of this abstract will be available in Part II the 2011 Annual Meeting Proceedings, distributed onsite at on June 4, 2011, and as a supplement to 20, issue Journal Clinical Oncology.
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently constitutes the leading and overwhelming health issue worldwide. In comparison with adults, children present milder symptoms, most having an asymptomatic course. We hypothesized that COVID-19 infection has a negative impact on continuation of chemotherapy increases nonrelapse mortality. Material methods This study was performed to assess course SARS-CoV-2...
Despite the progress that has been made in recent decades treatment of pediatric acute leukemias, e.g., converting lymphoblastic leukemia (ALL) from a fatal to highly curable disease, 15-20% children still relapse. Blinatumomab, bispecific CD3/CD19 antibody construct, successfully used relapsed/refractory r/r B-cell precursor ALL (BCP-ALL) as bridge hematopoietic stem cell transplantation (HSCT). We retrospectively assessed efficacy and toxicity blinatumomab 13 with BCP-ALL. Between 2017...
Prognosis in children with refractory and relapsed high-risk neuroblastoma is poor. Only a minority of patients obtain remission when treated second-line chemotherapy regimens. Chemotherapy combined anti-GD2 antibodies has previously been shown to increase response survival rates. We retrospectively analyzed cohort 25 or who were irinotecan/temozolomide combination the antibody dinutuximab beta. The therapy resulted an objective rate 64%, 32% achieving complete response. Response treatment...
Background/aim: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment childhood cancers is still evolving. aim this nationwide retrospective study was to assess safety and effectiveness ICIs used a group 42 patients, with median age 13.6 years, various types advanced malignancies treated pediatric oncology centers Poland between 2015 2023. Results: indications for anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); other (14)....
Myeloid leukemia of Down syndrome has a better prognosis than sporadic pediatric acute myeloid leukemia. Most cases are characterized by additional cytogenetic changes besides the constitutional trisomy 21, but their potential prognostic impact is not known. We, therefore, conducted an international retrospective study clinical characteristics, cytogenetics, treatment, and outcome 451 children with syndrome. All karyotypes were centrally reviewed before assigning patients to subgroups. The...
The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, most common childhood eye cancer. We aimed investigate burden and its on clinical presentation in large sample of patients with retinoblastoma Africa Europe.A cross-sectional analysis including 518 treatment-naïve residing 40 European countries 1024 43 African countries.Capture rate was 42.2% expected 108.8% Europe. were older (95% CI -12.4 -5.4,...