A5026240360- Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Radiomics and Machine Learning in Medical Imaging
- Acute Myeloid Leukemia Research
- Childhood Cancer Survivors' Quality of Life
- Genetic factors in colorectal cancer
- Blood transfusion and management
- Hematopoietic Stem Cell Transplantation
- Erythropoietin and Anemia Treatment
- Monoclonal and Polyclonal Antibodies Research
- T-cell and Retrovirus Studies
- Lung Cancer Research Studies
- Statistical Methods in Clinical Trials
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Multiple Myeloma Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Ischemia and Reperfusion
- Cancer Genomics and Diagnostics
Leipzig University
2016-2025
Hudson Institute
2023
University Hospital Leipzig
2014-2019
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2000-2016
Institute for Medical Informatics and Biostatistics
2015
Martin Luther University Halle-Wittenberg
2011
University Hospital Münster
2011
Saarland University
1991-2010
St Anna Children's Hospital
2010
Medical University of Vienna
2010
Two thirds of patients with advanced Hodgkin's disease are cured current approaches to treatment. Prediction the outcome is important avoid overtreating some and identify others in whom standard treatment likely fail.Data were collected from 25 centers study groups on a total 5141 treated combination chemotherapy for disease, or without radiotherapy. The data included 19 demographic clinical characteristics at diagnosis. end point was freedom progression disease. Complete available 1618...
The distinction between Burkitt's lymphoma and diffuse large-B-cell is unclear. We used transcriptional genomic profiling to define more precisely distinguish subgroups in other types of mature aggressive B-cell lymphomas.We performed gene-expression using Affymetrix U133A GeneChips with RNA from 220 lymphomas, including a core group 8 lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for was generated, chromosomal abnormalities were detected interphase...
Faced with unsatisfactory results of treatment for advanced Hodgkin's disease, we investigated three combinations chemotherapy.From 1993 to 1998, 1201 eligible patients 15 65 years age who had newly diagnosed disease in unfavorable stage IIB or IIIA IIIB IV were randomly assigned receive eight cycles cyclophosphamide, vincristine, procarbazine, and prednisone alternating doxorubicin, bleomycin, vinblastine, dacarbazine (COPP-ABVD); etoposide, (BEACOPP); increased-dose BEACOPP, each followed...
Remote ischemic preconditioning (RIPC) is reported to reduce biomarkers of and reperfusion injury in patients undergoing cardiac surgery, but uncertainty about clinical outcomes remains.We conducted a prospective, double-blind, multicenter, randomized, controlled trial involving adults who were scheduled for elective surgery requiring cardiopulmonary bypass under total anesthesia with intravenous propofol. The compared upper-limb RIPC sham intervention. primary end point was composite death,...
The International Prognostic Index (IPI) is widely used for risk stratification of patients with aggressive B-cell lymphoma. introduction rituximab has markedly improved outcome, and R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisone) become the standard treatment CD20(+) diffuse large To investigate whether IPI maintained its power when combined CHOP, we analyzed prognostic relevance in three prospective clinical trials.In total, 1,062 treated were included (MabThera...
Purpose The HD9 trial of the German Hodgkin Study Group compared two different doses (baseline and escalated) bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone (BEACOPP) chemotherapy regimen in 1,196 patients with advanced-stage Hodgkin's lymphoma (HL). previous analysis 5 years median follow-up had indicated improved tumor control BEACOPP escalated. Since long-term safety efficacy this has been debated, we report 10-year follow-up. Patients Methods...
To investigate whether radiotherapy can be reduced without loss of efficacy from extended field (EF) to involved (IF) after four cycles chemotherapy.Between 1993 and 1998, patients with newly diagnosed early-stage unfavorable HD were enrolled onto this multicenter study. Patients randomly assigned receive cyclophosphamide, vincristine, procarbazine, prednisone (COPP) + doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) for two followed by 30 Gy EF 10 bulky disease (arm A) or IF B).Of...
Stratification of head and neck squamous cell carcinomas (HNSCC) based on HPV16 DNA RNA status, gene expression patterns, mutated candidate genes may facilitate patient treatment decision. We characterize with different (E6*I) status from 290 consecutively recruited patients by profiling targeted sequencing 50 genes. show that tumors transcriptionally inactive (DNA+ RNA-) are similar to HPV-negative (DNA-) regarding frequency TP53 mutations (47%, 8/17 43%, 72/167, respectively). also find an...
To investigate whether combined-modality treatment (CMT) with two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by extended-field radiotherapy (EF-RT) is superior to EF-RT alone in patients early favorable Hodgkin's lymphoma (HL).Between 1993 1998, 650 newly diagnosed, histology-proven HL clinical stages IA IIB without risk factors were enrolled onto this multicenter study randomly assigned receive 30 Gy plus 10 the involved field (arm A) or ABVD same B)....
Purpose Vincristine, etoposide, prednisone, and doxorubicin (OEPA)–cyclophosphamide, vincristine, dacarbazine (COPDAC) is derived from standard procarbazine, (OPPA)–cyclophosphamide, prednisone (COPP) chemotherapy by replacing procarbazine with etoposide for a potentially less gonadotoxic regimen boys Hodgkin's lymphoma (HL). Patients Methods Five hundred seventy-three pediatric patients classical HL were enrolled onto the German Society of Pediatric Oncology Hematology–Hodgkin's Disease...
HER3 (erbB-3) is a member of the epidermal growth factor receptor (EGFR) family. After dimerization with other members EGFR family several signal transduction cascades can be activated, including phosphoinosite 3'-kinase (PI3-K)/Akt and extracellular signal-regulated kinase (ERK1/2). Here, we studied possible association between expression prognosis in patients ovarian cancer.Tumor tissue 116 consecutive diagnosed primary epithelial cancer 1986 1995 was analyzed immunohistochemically for...
PURPOSE The HD9 trial aims to evaluate whether moderate dose escalation and/or acceleration of standard polychemotherapy is beneficial for advanced-stage Hodgkin's disease (HD). Two variants a novel bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) scheme (standard escalated dose) are compared with (COPP)/doxorubicin, vinblastine, dacarbazine (ABVD). PATIENTS AND METHODS randomized, three-arm recruited patients in stages IIB IIIA risk...
Chromosomal translocations affecting the MYC oncogene are biological hallmark of Burkitt lymphomas but also occur in a subset other mature B-cell lymphomas. If accompanied by chromosomal break targeting BCL2 and/or BCL6 these translocation-positive (MYC+) called double-hit lymphomas, otherwise term single-hit is applied. In order to characterize features MYC+ than lymphoma we explored, after exclusion molecular as defined gene expression profiling, molecular, pathological and clinical...
Purpose Currently, a routine bone marrow biopsy (BMB) is performed to detect (BM) involvement in pediatric Hodgkin's lymphoma (HL) stage greater than IIA. [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) increasingly used for the initial staging of HL. The value using FDG-PET BM has not been sufficiently defined. We compared results BMBs and diagnosis large group with Patients Methods 175 patients newly diagnosed classical HL IIA was determined by BMB, FDG-PET, chest computed...
<h3>Background & Aims</h3> A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, largely retrospective data, propose omitting biopsy analysis for patients with concentrations IgA against tissue transglutaminase (IgA-TTG) >10-fold the upper limit normal (ULN) if further criteria are met. study concluded that measurements IgA-TTG total IgA, or IgG deamidated gliadin (IgG-DGL) could identify without disease....