A5088703623- Scoliosis diagnosis and treatment
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Spinal Fractures and Fixation Techniques
- Endometrial and Cervical Cancer Treatments
- Pituitary Gland Disorders and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Adipose Tissue and Metabolism
- Reproductive Biology and Fertility
- Connective tissue disorders research
- Sperm and Testicular Function
- Regulation of Appetite and Obesity
- Cancer, Hypoxia, and Metabolism
- Ultrasound Imaging and Elastography
- Spine and Intervertebral Disc Pathology
- Hypothalamic control of reproductive hormones
- Gut microbiota and health
- Sexual Differentiation and Disorders
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cell death mechanisms and regulation
- Pregnancy-related medical research
- Thyroid Cancer Diagnosis and Treatment
Poznan University of Medical Sciences
2016-2025
University Hospital Schleswig-Holstein
2011
University of Lübeck
2011
Kiel University
2011
Nicotinamide phosphorybosiltransferase (NAMPT) plays an important role in the regulation of cellular growth, angiogenesis, and apoptosis mammalian cells. NAMPT overexpression has been recently found colorectal, breast, prostatic, gastric, esophageal, pancreatic cancers, specific inhibitors might be adjuvant therapeutic modalities. In this study, we analyzed expression 40 malignant 67 benign thyroid tissue samples using qPCR. We also investigated relationships between survivin/survivin...
The life satisfaction of parents children with cerebral palsy should be assessed. Parenting a child disability may bring more challenges and efforts, impacting overall quality life. the study aimed to evaluate palsy. was designed assess To measure this outcome, we developed an original survey consisting 29 questions inspired by Satisfaction With Life Scale (SWLS). involved 43 or legal guardians diagnosed A correlation identified between parental amount leisure time reported (p = 0.004, R...
Background/Objectives: Endometriosis is a painful chronic condition in which the endometrium grows outside uterus. The epithelial–mesenchymal transition (EMT) critical to endometriosis progression, where cells lose epithelial traits and gain invasiveness. Methods: This study investigates effects of phoenixin-14 (PNX-14), neuropeptide found at reduced levels patients, on expression two molecular EMT markers, CDH1 (E-cadherin) THBS2 (thrombospondin 2), as well cell viability...
Background/Objectives: Autism spectrum disorder (ASD) is a heterogeneous condition with diverse symptoms influenced by factors like gender, severity and the involvement of family therapists. While many risk that contribute to ASD development are known, exact etiology remains unclear. The relationship between speech ability postural/gait patterns in has not been extensively studied. This study aimed verify if speak can affect body posture gait patterns. Methods: involved 28 boys aged 6–17....
Background/Objectives: Many prison-sentenced individuals exhibit symptoms of mental dysfunctions, including attention deficit hyperactivity disorder (ADHD). The presence co-occurring disorders further complicates their rehabilitation and social reintegration efforts. Given these challenges, understanding the role specific disorders, such as ADHD, is critical for developing targeted interventions tailored to needs incarcerated improving outcomes. This research aimed clarify relationships...
Endometrial cancer (EC) is the second most frequent gynecological malignancy and sixth common women's worldwide. EC incidence rate increasing rapidly. Apart from classical, we should consider angiogenesis hypoxia-related genes as a reason for manifestation progression. We compared patterns of HIF1A, EPAS1, VEGFA (genes interest - GOIs) mRNA expression in 92 cases. HIF1A levels were higher patients than controls. differed significantly between controls both tumor grades G2 G3, observed...
MicroRNAs (miRNAs) are highly conserved small non-coding RNAs, that modulate gene expression by targeting messenger RNA of many processes. Thus, miRNAs key regulators both physiological and pathological settings. Reliable results quantitative miRNA evaluation depend on suitable reference genes (RGs) for data normalization. To date, no consensus has been reached the best RG muscle tissue. We assessed RGs stability in skeletal tissue patients with spinal deformity. Ninety samples were obtained...
Secretion of human chorionic gonadotropin, especially its beta subunit by malignant trophoblastic tumors and varieties different origin is now well documented; however the role hCG in tumorogenesis still unknown. This study documents molecular presence gonadotropin uterine cervix cancer tissues investigates a novel technique to reduce hCGβ levels based on expression modified U1 snRNA as method hormone's biology cervical cells cultured vitro. The property block accumulation specific RNA...
Introduction XbaI single nucleotide polymorphism (SNP) (A/G rs934099) in estrogen receptor 1 gene (ESR1) was described to be associated with curve severity Japanese idiopathic scoliosis (IS) patients and Chinese both predisposition IS. PvuII SNP (C/T rs2234693) of ESR1 the occurrence IS population; however, two replication studies did not confirm findings. The SNPs have never been studied Caucasian patients. Methods Case-control study. 287 females underwent clinical, radiological genetic...
Idiopathic scoliosis (IS) is a multifactorial disease with epigenetic modifications. Tissue dependent and differentially methylated regions (T-DMRs) may regulate tissue-specific expression of the estrogen receptor 1 gene (ESR1). This study aimed to analyze methylation levels within T-DMR1 T-DMR2 its concatenation ESR1 IS patients. The involved 87 tissue samples (deep paravertebral muscles, both on convex concave side curve, from back superficial muscles) 29 girls who underwent an operation...
A genetic association study of estrogen receptor 2 gene (ESR2) polymorphisms in idiopathic scoliosis (IS).To investigate the ESR2 with either predisposition to or progression IS Central European population.In rs1256120 polymorphism was described be associated and severity Chinese population. This observation has not been confirmed Japanese The rs4986938 rs1256049 were present breast cancer, rheumatoid arthritis, bone mineral density, however evaluated.Case-control 248 females 243 healthy...
Summary Background Irisin is a new adipo‐myokine, encoded by the FNDC 5 gene. Currently, there discussion regarding relation between thyroid function and irisin concentration. This prospective study assesses influence of thyrometabolic changes on serum concentration in association with altered muscle metabolism. performed large cohort patients affected severe hypo‐ or hyperthyroidism, as well expression gene tissue different pathologies. Methods The group comprised 119 newly diagnosed...
Small integral membrane protein 20/phoenixin (SMIM20/PNX) and its receptor GPR173 (G Protein-Coupled Receptor 173) play a role in the regulation of hypothalamic-pituitary-gonadal axis (HPG). The aim study was to determine PNX, FSH, LH, 17β-estradiol association women with endometriosis, expression SMIM20/PNX signaling via GPR173. Serum concentrations were measured by enzyme electrochemiluminescence immunoassay. eutopic ectopic endometrium assessed qPCR immunohistochemistry. Reduced PNX...
Abstract The early-life modifications of intestinal microbiota may impact children's subsequent emotional and cognitive development. Studies show that some bacteria species in gut microbiota, the lack others, play a key role autism spectrum disorders (ASD) Fecal samples were obtained from three groups children: 16 healthy, 24 with allergies (ALG), 33 ASD (probiotics non-probiotics users). analysis was carried out according to KyberKompakt Pro protocol. We observed significantly higher level...
<h3>Objectives:</h3> Recent studies propose the role of gonadotropins in development and growth endometrial carcinoma. The present research was undertaken to establish expression human chorionic gonadotropin (<i>hCG</i>), gonadotropin-releasing hormones 1 (<i>GnRH1</i> <i>GnRH2</i>, respectively) their receptors hyperplasias <h3>Material Methods:</h3> analyzed genes carcinoma hyperplasia with without atypia evaluated using reverse transcriptase polymerase chain reaction immunohistochemistry....
The age at menarche (AAM) is commonly in use patients with IS as one of the maturity indicator suggesting deceleration growth velocity. AAM was suggested to be related predisposition and curve progression potential IS. late reported associated higher prevalence adolescent idiopathic scoliosis. determined by both genetic environmental factors well their interactions. Estrogen receptors 1 2 polymorphism were AAM: ESR1 XbaI PvuII site ESR2 AluI polymorphism. purpose study investigate...
Abstract Idiopathic scoliosis (IS) is one of the most common spinal disorders in adolescents. Despite many studies, etiopathogenesis IS still poorly understood. In recent years, role epigenetic factors has been increasingly investigated. It also postulated that development and progression disease related to gender puberty, could be associated with estrogen action. Estrogen hormones act via receptor 1 (ESR1) 2 (ESR2). suggested ESR2 expression dependent on methylation within its gene...
Ovarian cancer remains the leading cause of death due to gynecologic malignancy. Estrogen-related pathways genes, such as estrogen receptors (ESR1 and ESR2) their coregulators, proline-, glutamic acid-, leucine-rich protein 1 (PELP1), proto-oncogene tyrosine-protein kinase c-Src (SRC) are involved in ovarian induction development, still they require in-depth study. In our study, tissue samples were obtained from 52 females Caucasian descent (control group without cancerous evidence (n = 27),...
Thyroid cancer incidence has increased significantly during the past decades and is most common type of endocrine malignancy. Many factors in thyroid cancers were studied as independent predictors a poor prognosis.The objective study was to evaluate survivin expression - BIRC5 its splice variants: delta Ex3 2B benign malignant nodules.Thyroid tissues samples from group 50 patients consisting of: 29 with (including medullary, papillary, follicular undifferentiated types), well 21...
MicroRNAs (miRNAs) are highly conserved small non-coding RNAs, that modulate gene expression by targeting messenger RNA of many processes. Thus, miRNAs key regulators both physiological and pathological settings. Reliable results quantitative miRNA evaluation depend on suitable reference genes (RGs) for data normalization. To date, no consensus has been reached the best RG muscle tissue. We assessed RGs stability in skeletal tissue patients with spinal deformity. Ninety samples were obtained...
Abstract Background Metastasis is a common feature of many advanced stage cancers and metastatic spread thought to be responsible for cancer progression. Most cells are localized in the primary tumor only small population circulating (CTC) has potential. CTC amount reflects aggressiveness tumors, therefore their detection can used determine prognosis treatment patients. The aim this study was evaluate human chorionic gonadotropin beta subunit (CGB) gonadoliberin type 1 (GNRH1) expression as...