Wanda Badowska
A5076714732- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Chronic Myeloid Leukemia Treatments
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
- Cytomegalovirus and herpesvirus research
- Multiple and Secondary Primary Cancers
- Autoimmune and Inflammatory Disorders Research
- Infectious Diseases and Mycology
- Polyomavirus and related diseases
- Hemophilia Treatment and Research
- Pluripotent Stem Cells Research
- Adolescent and Pediatric Healthcare
- Parvovirus B19 Infection Studies
- Platelet Disorders and Treatments
- Drug Transport and Resistance Mechanisms
- Pharmaceutical studies and practices
- PI3K/AKT/mTOR signaling in cancer
- Ethics and Legal Issues in Pediatric Healthcare
- Amyotrophic Lateral Sclerosis Research
University of Computer Sciences and Economics in Olsztyn
2015-2024
Uniwersytecki Szpital Kliniczny w Olsztynie
2013-2024
University of Warmia and Mazury in Olsztyn
2014-2024
Poznan University of Medical Sciences
2021
Pomeranian Medical University
2021
Wojewódzki Szpital Specjalistyczny Nr 2
2010-2014
The inactivation of tumor suppressor genes located within 9p21 locus (CDKN2A, CDKN2B) occurs in up to 30% children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL), but its independent prognostic significance remains controversial. In order investigate the impact deletions and promoter methylation 9p21, 641 newly diagnosed BCP-ALL using specific multiplex ligation-dependent probe amplification (MS-MLPA) were investigated. A total 169 (26.4%) microdeletions detected, which 71...
Background: Acinetobacter, significantly A.baumannii, are becoming a great threat to hospitalized patients due increasing antibiotic resistance. The aim of this study was describe the epidemiology, clinical characteristic, antimicrobial susceptibility pattern and outcome Acinetobacter infections in pediatric cancer HSCT recipients Poland. Methods: total 125 episodes species were reported pa-tients < 18 years treated Polish hematology oncology centers over pe-riod from 2012 2023....
BACKGROUND:The aim of this study was to investigate repeated intrathecal injection autologous bone marrow-derived mesenchymal stem cells (BM-D MSCs) patients for treatment sporadic amyotrophic lateral sclerosis (ALS). MATERIAL AND METHODS:Autologous MSCs were isolated from the patients' marrow, plated, expanded, harvested, and passaged. Stem a single marrow collection used 3 injections per patient, given over 3-month period. Outcomes measured with Revised Amyotrophic Lateral Sclerosis...
In the last 40 years, considerable progress was made in treatment of childhood cancer. Nearly 80% children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. first Polish study analyzing general health status and epidemiology organ late effects cohort adolescent cancer survivors monitored by doctors registered on-line national database for (N = 1761). tool collects information on previous therapy current (medical history,...
Clostridium difficile infection (CDI) is one of the most common causes nosocomial infectious diarrhea in children during anticancer therapy or undergoing hematopoietic stem cell transplantation (HSCT) Europe. Immunosuppression these patients a risk factor for CDI. Malignant diseases, age, acute graft-versus-host disease (aGVHD), HLA mismatch, use total body irradiation may play an important role CDI course. The aim this study was to evaluate incidence, course, and outcome treated malignancy...
Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed results of AML treatment Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering treated with following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, 74), 98 (1998–2004, 151), AML-BFM 2004...
Acute P./myeloid leukemia post cytotoxic therapy (AML-pCT) is rare complication of cancer treatment in childhood. The objective the study was to identify clinical characteristics and provide an analysis outcomes pediatric AML-pCT. We retrospectively analyzed data 40 children with AML-pCT, treated from 2005 2020 within Polish Pediatric Leukemia Lymphoma Study Group. most common primary malignancies were acute lymphoblastic (32.5%) brain tumors (20%). median latency period 2.9 years (range:...
Since 1983 four consecutive unified regimens: acute myeloid leukemia-Polish pediatric leukemia/lymphoma study group (AML-PPLLSG) 83, AML-PPLLSG 94, 98 and AML-BFM 2004 Interim, for AML have been conducted by the Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG). In this paper, we review successive studies on basis of leukemia-Berlin-Frankfurt-Munster (AML-BFM) protocol, in which a stepwise improvement treatment outcome was observed. Treatment results last protocol Interim are presented...
We prospectively examined whether surface expression of Cytokine Receptor-Like Factor 2 (CRLF2) on leukemic blasts is associated with survival and induction treatment response in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients. Flow cytometric analysis bone marrow-derived cells revealed that 7.51% (29/286) 386 BCP-ALL patients were CRLF2-positive (CRLF2pos) at diagnosis. The median minimal residual disease (MRD) was lower CRLF2pos than CRLF2-negative (CRLF2neg) day...
The aim of this study was to assess the incidence DNA aneuploidy in Polish children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and relationship between immunological phenotype, age, leukocyte count, S-phase fraction (SPF) early response induction chemotherapy assessed by percentage residual blast cells bone marrow aspirates. group consisted 267 patients. content immunophenotype were before treatment using multicolor flow cytometry (FC). detected 50/267 (19%) High...
Myeloid sarcoma (MS) is an extramedullary malignant tumor composed of immature myeloid cells. It occurs in patients with acute leukemia (AML), myelodysplastic syndrome (MDS), or chronic (CML). MS may coincide disease diagnosis precede bone marrow involvement by months even years; it can also represent the manifestation a relapse (1, 2).The aim this study to describe clinical characteristics children diagnosed Poland as well analyze diagnostic methods, treatment, and outcomes including...
Background: Infectious complications (IC) caused by bacterial strains often impede anticancer therapy. The study aimed to retrospectively analyze IC that could help predict the risk and optimize empirical treatment for infections in pediatric cancer patients. Patients Methods: Over a 72-month period, all-in 5,599 children with cancer: 2,441 patients hematological malignancy (HM including acute leukemias, Hodgkin non-Hodgkin lymphomas [NHLs], Langerhans cell histiocytosis) 3,158 solid tumors...
Abstract Anti‐cancer treatment in children can deteriorate gonadal function and affect future fertility. We analyzed the hormonal markers of adolescent leukemia survivors, treated childhood with different levels aggressiveness. hormone 69 adolescents young adults, survivors stratified into standard (SR), intermediate (IR), high (HR) risk groups, 80 healthy controls (38 men) at a similar age. assessed follicular stimulating (FSH), luteinizing (LH), inhibin B whole group, testosterone males,...
Hemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome of life-threatening inflammation caused by an excessive, prolonged and ineffective immune response. An increasing number HLH cases recognized in Poland, but the genetic causes familial (FHL) have not been reported. We investigated molecular genetics associated outcomes pediatric patients who met criteria. studied 54 with HLH, 36 whom received studies. Twenty-five were subjected to direct sequencing PRF1, UNC13D, STX11, XIAP...
Recent studies showed relatively better outcome for children with refractory (refAML) and relapsed acute myeloid leukemia (relAML). Treatment of these patients has not been unified within Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG) so far. The goal this study is to analyze the results therapy performed between 2005-2011.The data 16 refAML 62 relAML were analyzed retrospectively. Reinduction was usually based on idarubicine, fludarabine cytarabine allogenic hematopoietic stem cell...
Background: Infections caused by Stenotrophomonas maltophilia (SM) have documented high mortality rate in immunocompromised patients. Aim: This nationwide multicenter study was performed to analyze the epidemiology of SM infections children undergoing anticancer therapy (pediatric hematology and oncology [PHO]) or hematopoietic cell transplantation (HCT) over 2012–2019, including incidence outcome infections, as well treatment regimens multidrug resistance. Methods: Cumulative calculated...
The effect of age on the incidence late sequelae that occur after anticancer treatment in childhood is still not fully elucidated. In this multicenter study long-term survivors diagnosed before three, we investigated prevalence effects many years treatment.The group (n = 561) was selected from Polish National Childhood Cancer Survivors Registry 1761) created 2007. A survivor defined as an individual who has survived at least 5 completion treatment. All children were between 1991 and 2016,...
Background. Chronic myeloid leukemia (CML) constitutes only 2–3% of all leukemias in pediatric patients. Philapelphia chromosome and BCR-ABL fusion are genetic hallmarks CML, their presence is crucial for targeted molecular therapy with tyrosine kinase inhibitors (TKIs), which replaced hematopoietic stem cell transplantation (HSCT) as a standard first-line therapy. The disease population rare, despite clinical similarities to CML adults, different approach needed, due the long lifetime...
The germline variant at rs3824662 in GATA3 is a risk locus for Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL), the biological subtype of B-cell precursor (BCP)-ALL defined by distinct gene expression profile and presence specific somatic aberrations including rearrangements CRLF2. In this study, we investigated whether associates with CRLF2 leukemic cells predicts prognosis pediatric BCP-ALL patients treated according to ALL Intercontinental Berlin-Frankfurt-Münster (IC BFM)...
The aim of this nationwide study was to describe the epidemiology and profile bacterial infections (BI), invasive fungal disease (IFD) viral (VI) in patients with de novo relapsed/refractory (rel/ref) acute myeloid leukemia (AML). Within studied group 250 children primary AML, at least one infectious complication (IC) diagnosed 76.0% (n = 190) including 85.1% 504) episodes BI, 8.3% 49) – IFD 6.6% 39) VI. Among 61 rel/ref IC found 67.2% 41) 78.8% 78) 14.1% 14) 7.1% 7) In all AML patients,...
Introduction. Factors promoting nerve cell ingrowth are considered responsible for chronic back pain resulting from the intervertebral disc degeneration (IDD). One of recent exploratory IDD treatments is stem transplantation therapy. The CD271 (low-affinity growth factor receptor) has been identified as a marker most homogeneous mesenchymal (MSC) subset. It capable differentiation along adipogenic, osteogenic and chondrogenic lineages producing significantly higher levels cytokines compared...
This study aimed to find novel genetic variants of susceptibility aspąergillosis in paediatric patients with haematological malignancies. Complete sequences fifteen genes human innate immunity (CCL2, CCR2, CD209, CLEC6A, CLEC7A and ten TLR genes) were studied 40 diagnosed disorders (20 unaffected 20 affected by aspergillosis). All samples sequenced MiSeq (Illumina) 454 (Roche Diagnostics) technologies. Statistical significance the differences between groups was determined using two-tailed...