A5054207725- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced organ toxicity mitigation
- Bone health and treatments
- Neuroblastoma Research and Treatments
- Cancer Risks and Factors
- Vitamin D Research Studies
- Acute Kidney Injury Research
- Renal and related cancers
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Acute Myeloid Leukemia Research
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Ethics and Legal Issues in Pediatric Healthcare
- Angiogenesis and VEGF in Cancer
- Genomics and Chromatin Dynamics
- Protease and Inhibitor Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- Signaling Pathways in Disease
- PARP inhibition in cancer therapy
- Galectins and Cancer Biology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune cells in cancer
Medical University of Białystok
2011-2024
Proline metabolism has been identified as a significant player in several neoplasms, but knowledge of its role gliomas is limited despite it providing promising line pursuit. Data on proline the brain are somewhat historical. This study aims to investigate alterations WHO grade 4 (GG4) context brain. A total 20 pairs samples were studied, consisting excised tumor and unaffected tissue, obtained when partial resection was required reach deep-seated lesions. Levels oxidase/proline...
Owing to advances in treatment modalities and supportive care, overall survival rates have reached up 90% among children with acute lymphoblastic leukemia (ALL). However, due the underlying illness therapy, they are at a greater risk of developing lifestyle diseases. Hence, special attention is paid early detection components metabolic syndrome (MetS). This study aimed investigating association plasma levels nine diabetes markers being overweight MetS ALL survivors. The included 56 subjects...
Childhood acute lymphoblastic leukemia (ALL) survivors are at higher risk of developing many late effects later in life. They experience multiple health problems that have significant public implications, such as frailty, premature onset lifestyle diseases, and second tumors. There is some evidence chronic inflammation causes accelerated aging childhood cancer survivors; however, the available data very limited. The aim study was to evaluate broad panel cytokines among asymptomatic ALL after...
Abstract Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used supportive care may induce acute kidney injury (AKI) or lead to chronic disease (CKD). The aim this study was test the hypothesis whether urinary molecule-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL) are increased lymphoblastic leukemia (ALL) survivors. Method cohort consisted 86 patients...
Abstract Anti‐cancer treatment in children can deteriorate gonadal function and affect future fertility. We analyzed the hormonal markers of adolescent leukemia survivors, treated childhood with different levels aggressiveness. hormone 69 adolescents young adults, survivors stratified into standard (SR), intermediate (IR), high (HR) risk groups, 80 healthy controls (38 men) at a similar age. assessed follicular stimulating (FSH), luteinizing (LH), inhibin B whole group, testosterone males,...
The deterioration of renal function after childhood solid tumors treatment is the result using intensive multimodal therapy. In recent years, urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been introduced as potential promising biomarkers early damage. aim present study was to determine whether anticancer has any effect on concentration KIM-1 NGAL its association with impairment in survivors tumors. Sixty patients previously treated for...
A new method was developed for the simultaneous determination of vascular endothelial growth factor (VEGF-A) and fibroblast factor-2 (FGF-2) in blood serum, using biosensors with array Surface Plasmon Resonance imaging (SPRi) detection. It can be applied as a single VEGF-A FGF-2 or two separate methods testing only one selected protein each case. Validation carried out method. Limit detection (LOD) limit quantification (LOQ) values were determined found not to differ significantly from...
We examined the association between adipokines (leptin, adiponectin, and resistin), radiotherapy, measurement of body fat, insulin resistance among young adult survivors childhood cancer (CCS). Materials Methods. Seventy-six were included (mean age<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">24.1</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">3.5</mml:mn></mml:math>years). Insulin (IR) was calculated using homeostasis model assessment...
Over the last decades, overall survival rate for childhood cancer has increased from 20% to 80%, which is result of advances in treatment. Nevertheless, most data international registers survivors (CCS) stress that this population patients at high risk late sequelae and their biological aging starts earlier life. Anticancer therapy (chemotherapy, radiotherapy, surgery, immunotherapy) affects intracellular processes leading chronic deterioration organ function premature senescence. The...
The effect of age on the incidence late sequelae that occur after anticancer treatment in childhood is still not fully elucidated. In this multicenter study long-term survivors diagnosed before three, we investigated prevalence effects many years treatment.The group (n = 561) was selected from Polish National Childhood Cancer Survivors Registry 1761) created 2007. A survivor defined as an individual who has survived at least 5 completion treatment. All children were between 1991 and 2016,...
Childhood cancer survivors are in augmented risk for developing obesity. For many factors leptin and receptor gene polymorphism play an important role the development metabolism not only of fat, but also, bone tissue. The aim analysis was to find relationships between Q223R, levels, anthropometric parameters. Patients Methods. In study 74 participated (ALL n = 64, lymphomas 10), control group consisted 51 healthy peers. Leptin blood concentration determined by ELISA method. To estimate...
During the last years, changes in diagnosis and treatment have caused a significant increase of number young adults who experienced cancer childhood. This enlarging population is affected by many health problems, including multiple hormone deficiencies bone mineral deficits. first polish study assessing density endocrine status adult survivors.A total 76 long-term survivors treated for pediatric were identified. The mean age at time was 24.1 ±3.5 years. Bone TSH, fT3, fT4, FSH, LH, estradiol...
Patients suffering from childhood acute lymphoblastic leukemia (ALL) are at risk of late adverse treatment-related effects. The examination targeted biomarkers could be used to improve the diagnosis and prediction life-threatening ALL sequelae. purpose this cross-sectional study was search for alterations in apolipoprotein (Apo) levels as potential markers occurrence obesity subjects treated ALL, assess relationships between weight, gender, anticancer treatment, Apo concentrations....
Childhood cancer survivors are highly exposed to the development of side effects after many years cessation anticancer treatment, including altered lipid metabolism that may result in an increased risk overweight and metabolic syndrome. Adipocyte (A-FABP) epidermal (E-FABP) fatty acid-binding proteins expressed adipocytes assumed play important role disturbances leading onset The aim this study was investigate association between serum A-FABP E-FABP levels, overweight, components syndrome...
The objectives of this study were to evaluate urinary beta-2-microglobulin (β2M) levels in long-term childhood cancer survivors and establish its association with anticancer drug-induced nephrotoxicity. consisted 165 (CCS) who continuous complete remission. We reported that CCS had a significantly higher level β2M (p < 0.001) β2M/Cr. ratio 0.05) than healthy peers. Among all participants, 24 (14.5%) decreased eGFR (<90 mL/min/1.73 m2). A significant positive correlation between body...
Acute lymphoblastic leukemia (ALL) and glioma are some of the most common malignancies, with ALL often affecting children adult men. Proangiogenic cytokines growth factors play an important role in development both these tumors. Glioma is characterized by extremely extensive network blood vessels, which continues to expand mainly process neoangiogenesis, direct inducers from family vascular endothelial factors, i.e., factor (VEGF-A) its receptor 2 (VEGF-R2), as well a cytokine fibroblast...
Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and cardiovascular diseases. aims this study were to assess the serum α-Klotho FGF23 levels CCSs determine their association with nephro- cardiotoxicity. Methods: This evaluated cohort 66 who remained continuous remission, mean follow-up 8.41 ± 3.76 years. Results:...