A5070341654- Childhood Cancer Survivors' Quality of Life
- Acute Lymphoblastic Leukemia research
- Chemotherapy-induced organ toxicity mitigation
- Renal and related cancers
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer, Hypoxia, and Metabolism
- Acute Kidney Injury Research
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Neuroblastoma Research and Treatments
- Cancer Risks and Factors
- Acute Myeloid Leukemia Research
- Muscle and Compartmental Disorders
- Abdominal vascular conditions and treatments
- Family Support in Illness
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Genetic and Kidney Cyst Diseases
- Parathyroid Disorders and Treatments
- Galectins and Cancer Biology
- Vitamin D Research Studies
- Pharmacological Effects and Toxicity Studies
- Immune cells in cancer
- Statistical Methods and Inference
Medical University of Białystok
2018-2024
Ovarian cancer is a non-homogenous malignancy. High-grade serous carcinoma (HGSC) the most common subtype, and its drug resistance mechanisms remain unclear. Despite advantages of modern pharmacotherapy, high-grade ovarian associated with poor prognosis research into targeted therapies in progress. The aim study was to assess dominant energy substrate transport mechanism cells verify whether genomic aberrations could predict clinical outcomes using Cancer Genome Atlas (TCGA) dataset. Total...
Owing to advances in treatment modalities and supportive care, overall survival rates have reached up 90% among children with acute lymphoblastic leukemia (ALL). However, due the underlying illness therapy, they are at a greater risk of developing lifestyle diseases. Hence, special attention is paid early detection components metabolic syndrome (MetS). This study aimed investigating association plasma levels nine diabetes markers being overweight MetS ALL survivors. The included 56 subjects...
Childhood acute lymphoblastic leukemia (ALL) survivors are at higher risk of developing many late effects later in life. They experience multiple health problems that have significant public implications, such as frailty, premature onset lifestyle diseases, and second tumors. There is some evidence chronic inflammation causes accelerated aging childhood cancer survivors; however, the available data very limited. The aim study was to evaluate broad panel cytokines among asymptomatic ALL after...
Abstract Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used supportive care may induce acute kidney injury (AKI) or lead to chronic disease (CKD). The aim this study was test the hypothesis whether urinary molecule-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL) are increased lymphoblastic leukemia (ALL) survivors. Method cohort consisted 86 patients...
The deterioration of renal function after childhood solid tumors treatment is the result using intensive multimodal therapy. In recent years, urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been introduced as potential promising biomarkers early damage. aim present study was to determine whether anticancer has any effect on concentration KIM-1 NGAL its association with impairment in survivors tumors. Sixty patients previously treated for...
Patients suffering from childhood acute lymphoblastic leukemia (ALL) are at risk of late adverse treatment-related effects. The examination targeted biomarkers could be used to improve the diagnosis and prediction life-threatening ALL sequelae. purpose this cross-sectional study was search for alterations in apolipoprotein (Apo) levels as potential markers occurrence obesity subjects treated ALL, assess relationships between weight, gender, anticancer treatment, Apo concentrations....
Childhood cancer survivors are highly exposed to the development of side effects after many years cessation anticancer treatment, including altered lipid metabolism that may result in an increased risk overweight and metabolic syndrome. Adipocyte (A-FABP) epidermal (E-FABP) fatty acid-binding proteins expressed adipocytes assumed play important role disturbances leading onset The aim this study was investigate association between serum A-FABP E-FABP levels, overweight, components syndrome...
The objectives of this study were to evaluate urinary beta-2-microglobulin (β2M) levels in long-term childhood cancer survivors and establish its association with anticancer drug-induced nephrotoxicity. consisted 165 (CCS) who continuous complete remission. We reported that CCS had a significantly higher level β2M (p < 0.001) β2M/Cr. ratio 0.05) than healthy peers. Among all participants, 24 (14.5%) decreased eGFR (<90 mL/min/1.73 m2). A significant positive correlation between body...
Abstract Log-linear analysis is a practical tool for examining relationships, successfully applied in many fields of science. This paper discusses the topic estimation chance getting pregnant couples that underwent ART insemination. The authors focus on finding significant interactions between variables, basis which statistical models are built. With use results log-linear analysis, model predicting chances achieving clinical pregnancy contained was Moreover, it more complete than obtained...
Acute lymphoblastic leukemia (ALL) and glioma are some of the most common malignancies, with ALL often affecting children adult men. Proangiogenic cytokines growth factors play an important role in development both these tumors. Glioma is characterized by extremely extensive network blood vessels, which continues to expand mainly process neoangiogenesis, direct inducers from family vascular endothelial factors, i.e., factor (VEGF-A) its receptor 2 (VEGF-R2), as well a cytokine fibroblast...
Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and cardiovascular diseases. aims this study were to assess the serum α-Klotho FGF23 levels CCSs determine their association with nephro- cardiotoxicity. Methods: This evaluated cohort 66 who remained continuous remission, mean follow-up 8.41 ± 3.76 years. Results:...
The aim of this study was to evaluate the galectin-3 (Gal-3) level in children with a congenital solitary functioning kidney (cSFK) and determine its association common renal function parameters. consisted 68 (49 males) cSFK. We demonstrated that cSFK had lower than healthy subjects (p < 0.001). No significant differences serum cystatin C (Cys C) levels between reference group were found. reduced estimated glomerular filtration rate (eGFR) significantly higher Gal-3 Cys compared those...
Childhood cancer survivors (CCS) are predisposed to developing numerous late effects of anticancer treatment later in life. The existing literature suggests that vitamin D deficiency (VDD) may influence cardiovascular abnormalities and metabolic diseases. objectives this study were investigate the prevalence VDD among childhood examine association carotid intima-media thickness (IMT). comprised 111 (62 males, 49 females) with a median follow-up time 6.14 years. Vitamin status was determined...