A5032725451- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Bone health and treatments
- Bone health and osteoporosis research
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Cancer-related cognitive impairment studies
- Neuroblastoma Research and Treatments
- Bone and Joint Diseases
- Regulation of Appetite and Obesity
- Cancer Risks and Factors
- Retinoids in leukemia and cellular processes
- Vitamin D Research Studies
- Polish Legal and Social Issues
- Nutrition and Health in Aging
- Palliative Care and End-of-Life Issues
- Chemotherapy-induced organ toxicity mitigation
- Multiple and Secondary Primary Cancers
- Family Support in Illness
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Sarcoma Diagnosis and Treatment
- Medical Imaging and Pathology Studies
Medical University of Białystok
2015-2024
Medical University of Warsaw
2022
Medical University of Silesia
2022
University Clinical Hospital In Bialystok
2017
Owing to advances in treatment modalities and supportive care, overall survival rates have reached up 90% among children with acute lymphoblastic leukemia (ALL). However, due the underlying illness therapy, they are at a greater risk of developing lifestyle diseases. Hence, special attention is paid early detection components metabolic syndrome (MetS). This study aimed investigating association plasma levels nine diabetes markers being overweight MetS ALL survivors. The included 56 subjects...
Childhood acute lymphoblastic leukemia (ALL) survivors are at higher risk of developing many late effects later in life. They experience multiple health problems that have significant public implications, such as frailty, premature onset lifestyle diseases, and second tumors. There is some evidence chronic inflammation causes accelerated aging childhood cancer survivors; however, the available data very limited. The aim study was to evaluate broad panel cytokines among asymptomatic ALL after...
We prospectively examined whether surface expression of Cytokine Receptor-Like Factor 2 (CRLF2) on leukemic blasts is associated with survival and induction treatment response in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients. Flow cytometric analysis bone marrow-derived cells revealed that 7.51% (29/286) 386 BCP-ALL patients were CRLF2-positive (CRLF2pos) at diagnosis. The median minimal residual disease (MRD) was lower CRLF2pos than CRLF2-negative (CRLF2neg) day...
Abstract Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used supportive care may induce acute kidney injury (AKI) or lead to chronic disease (CKD). The aim this study was test the hypothesis whether urinary molecule-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL) are increased lymphoblastic leukemia (ALL) survivors. Method cohort consisted 86 patients...
Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed results of AML treatment Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering treated with following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, 74), 98 (1998–2004, 151), AML-BFM 2004...
Acute P./myeloid leukemia post cytotoxic therapy (AML-pCT) is rare complication of cancer treatment in childhood. The objective the study was to identify clinical characteristics and provide an analysis outcomes pediatric AML-pCT. We retrospectively analyzed data 40 children with AML-pCT, treated from 2005 2020 within Polish Pediatric Leukemia Lymphoma Study Group. most common primary malignancies were acute lymphoblastic (32.5%) brain tumors (20%). median latency period 2.9 years (range:...
Since 1983 four consecutive unified regimens: acute myeloid leukemia-Polish pediatric leukemia/lymphoma study group (AML-PPLLSG) 83, AML-PPLLSG 94, 98 and AML-BFM 2004 Interim, for AML have been conducted by the Polish Pediatric Leukemia/Lymphoma Study Group (PPLLSG). In this paper, we review successive studies on basis of leukemia-Berlin-Frankfurt-Munster (AML-BFM) protocol, in which a stepwise improvement treatment outcome was observed. Treatment results last protocol Interim are presented...
The aim of this study was to assess the incidence DNA aneuploidy in Polish children with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and relationship between immunological phenotype, age, leukocyte count, S-phase fraction (SPF) early response induction chemotherapy assessed by percentage residual blast cells bone marrow aspirates. group consisted 267 patients. content immunophenotype were before treatment using multicolor flow cytometry (FC). detected 50/267 (19%) High...
Total antioxidant status (TAS), and the influence of treatment correlation between TAS parameters involved in metabolic syndrome (MS) pediatric cancer survivors were evaluated. One hundred children adolescents studied. Twenty-five received radiotherapy, 12 obese or overweight. Additionally, we analyzed eight with acute lymphoblastic leukemia (ALL) at diagnosis during after remission induction. The control group consisted 22 healthy children. Serum concentrations TAS, glucose, cholesterol,...
Abstract Anti‐cancer treatment in children can deteriorate gonadal function and affect future fertility. We analyzed the hormonal markers of adolescent leukemia survivors, treated childhood with different levels aggressiveness. hormone 69 adolescents young adults, survivors stratified into standard (SR), intermediate (IR), high (HR) risk groups, 80 healthy controls (38 men) at a similar age. assessed follicular stimulating (FSH), luteinizing (LH), inhibin B whole group, testosterone males,...
The deterioration of renal function after childhood solid tumors treatment is the result using intensive multimodal therapy. In recent years, urinary kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been introduced as potential promising biomarkers early damage. aim present study was to determine whether anticancer has any effect on concentration KIM-1 NGAL its association with impairment in survivors tumors. Sixty patients previously treated for...
Avascular necrosis (avn) is a complication of treatment for malignancies in children and adolescents. The authors present two-center retrospective experiences with avn treated acute lymphoblastic leukaemia or non-Hodgkin lymphoma (8 from 191 patients newly diagnosed disease total 19 sites). median age at diagnosis was 16.6 years. Avn observed 4.1% the group, higher among males than females (7/1), both during after therapy. Early process has enabled 7 to avoid surgical intervention. increased...
Abstract The aim of the study was to assess whether cerebrospinal fluid tau protein is associated with cognitive changes in children acute lymphoblastic leukemia (ALL). Examination 38 ALL patients revealed a statistically significant increase on treatment day 59 and at two points during consolidation phase. Cognitive functioning examined 19 an average 3.7 years after diagnosis. level initiation maintenance therapy negatively correlated verbal abilities measured intellectual scale. suggests...
We examined the association between adipokines (leptin, adiponectin, and resistin), radiotherapy, measurement of body fat, insulin resistance among young adult survivors childhood cancer (CCS). Materials Methods. Seventy-six were included (mean age<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">24.1</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">3.5</mml:mn></mml:math>years). Insulin (IR) was calculated using homeostasis model assessment...
Comparison of transplant outcomes in long-term follow-up children after total body irradiation (TBI)- or chemotherapy-based conditioning allogeneic hematopoietic cell transplantation (allo-HCT).Patients undergoing allo-HCT for Acute lymphoblastic leukemia (ALL) conditioned either with TBI (n=55) chemotherapy (n=84) were compared. The following analyzed: overall survival (OS), event-free (EFS), relapse incidence (RI), and graft-versus-host-disease (GVHD)-free-relapse-free (GRFS).All analyzed...
The number of survivors childhood cancer has increased. Several studies in children and adults have shown relationships between lean mass (LM), fat (FM), bone mineral content (BMC). objective the study was to examine association body composition young cancer.Sixty-eight postpubertal participants (31 females 37 males) aged 15.5 27 years who were at least 5 after completion treatment for leukemia (n = 30), lymphoma 28), or solid tumors 10) studied. Anthropometry performed dual energy X-ray...
Cancer disease and its therapy (e.g., chemotherapeutic agents such as glucocorticoids, methotrexate, antymetabolities, cranial local irradiation) may severely disturb normal growth, bone mineral acquisition, skeletal development because most individuals go through the stages of rapid growth when childhood cancer is diagnosed.To identify factors associated with reduced density (BMD) in survivors authors examined 114 patients (70 males) who had been treated for acute lymphoblastic leukemia...
Childhood cancer survivors are in augmented risk for developing obesity. For many factors leptin and receptor gene polymorphism play an important role the development metabolism not only of fat, but also, bone tissue. The aim analysis was to find relationships between Q223R, levels, anthropometric parameters. Patients Methods. In study 74 participated (ALL n = 64, lymphomas 10), control group consisted 51 healthy peers. Leptin blood concentration determined by ELISA method. To estimate...
The germline variant at rs3824662 in GATA3 is a risk locus for Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL), the biological subtype of B-cell precursor (BCP)-ALL defined by distinct gene expression profile and presence specific somatic aberrations including rearrangements CRLF2. In this study, we investigated whether associates with CRLF2 leukemic cells predicts prognosis pediatric BCP-ALL patients treated according to ALL Intercontinental Berlin-Frankfurt-Münster (IC BFM)...
In this study the authors addressed question whether neurotoxicity due to chemotherapy of acute lymphoblastic leukemia (ALL) is associated with cerebrospinal fluid (CSF) oxidative stress. Examination 38 ALL patients revealed significant increases in 8-isoprostane concentration and important decreases total antioxidative capacity CSF during therapy. The mean level at diagnosis was 9.05 ± 1.62 pg/mL, no correlations initial leukocytosis, organomegaly, lactate dehydrogenase levels were noted....