A5103244134- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Neuroblastoma Research and Treatments
- Cardiac tumors and thrombi
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Bone Tumor Diagnosis and Treatments
- Pain Mechanisms and Treatments
- Management of metastatic bone disease
- Transcranial Magnetic Stimulation Studies
- Multiple and Secondary Primary Cancers
- Bone health and treatments
- Vascular Tumors and Angiosarcomas
- Cancer Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Social Issues in Poland
- Musculoskeletal pain and rehabilitation
- Molecular Biology Techniques and Applications
- Orthopedic Infections and Treatments
- Health, Work, and Social Studies in Poland
- Botulinum Toxin and Related Neurological Disorders
- Neural dynamics and brain function
- Spectroscopy Techniques in Biomedical and Chemical Research
- Soft tissue tumors and treatment
- Local Governance and Planning
UNSW Sydney
2020-2022
Neuroscience Research Australia
2020-2022
Patients with metastatic, progressive or recurrent Ewing sarcoma (ES) have a dismal outcome. The combination of irinotecan and temozolomide has been proposed as an effective salvage regimen for some pediatric malignancies. Thus, we sought to evaluate this vincristine patients relapsed refractory ES.Twenty-two ES were treated the (1.5 mg/m(2) i.v. day 1), (50 /day days 1-5) (125 p.o. (VIT) during period 2008-2012. All toxicities documented.A total 91 cycles (median 4.1 cycles/patient)...
Background With advances in cancer care, more young women with Ewing sarcoma (ES) survive after treatment. Thus, we sought to analyze the ovarian function prepubertal, pubertal and postpubertal females receiving multimodal therapy for ES, identify patients at risk of infertility on whom fertility preservation would be indicated. Procedures Twenty‐seven female survivors ES were included this retrospective multiinstitutional study. Patients classified into four groups according treatment...
Patients with metastatic, progressive, or recurrent bone tumors have a dismal outcome. Sorafenib has been proposed as an effective salvage regimen for some malignancies. Thus, we sought to evaluate this approach young patients relapsed refractory tumors. Twelve (two Ewing sarcoma, two chondrosarcoma, and eight osteosarcoma) received treatment sorafenib. All had standard tumor imaging laboratory evaluation. toxicities were documented. At the time of beginning sorafenib median age among 12 was...
Purpose . To check whether primary involvement of brain/spinal cord by bone/soft tissue sarcomas’ metastases in children is as rare described and to present various morphological forms CNS metastases. Methods Patients with first diagnosis 1999–2014 treated at single center were included whole course disease evaluation. Brain/spinal canal magnetic resonance imaging (MRI)/computed tomography performed cases suspicious for Extension from skull/vertebral column was excluded. Results 550 patients...
Abstract Background Ewing sarcoma (ES) is the second most common paediatric malignant bone tumor. Advances in multi‐disciplinary care have resulted significant improvement cure rates over last decades. However, generalization of those results countries traditionally excluded from large cooperative trials has yet to be demonstrated. We report modern for patients with ES Poland. Procedures One hundred and thirty‐two were treated using multi‐modal therapy during period 2000–2009. Overall...
Improved outcome prediction is vital for the delivery of risk-adjusted, appropriate and effective care to paediatric patients with Ewing sarcoma-the second most common malignant bone tumour. Fourier transform infrared (FTIR) spectroscopy tissues allows bulk biochemical content a biological sample be probed makes possible study diagnosis disease.In this retrospective study, FTIR spectra sections biopsy-obtained tissue were recorded. Twenty-seven (between 5 20 years age) newly diagnosed...
Advances in multidisciplinary care for pediatric cancer have resulted significant improvement cure rates over the last decades; however, these advances not been uniform across all age groups. Cancer is an important cause of perinatal mortality, yet full spectrum malignant neoplasms newborns well defined.The authors reviewed clinical features and outcomes 37 with congenital tumors treated at three referral centers North, Central, South Poland between 1980 2014. Event-free survival (EFS)...
Temporomandibular disorder is a common musculoskeletal pain condition with development of chronic symptoms in 49% patients. Although number biological factors have shown an association temporomandibular cross-sectional and case control studies, there are currently no biomarkers that can predict the symptoms. The PREDICT study aims to undertake analytical validation novel peak alpha frequency (PAF) corticomotor excitability (CME) biomarker signature using human model transition sustained...
Ewing sarcoma (ES) is a rare and aggressive disease that requires multidisciplinary treatment with the use of chemotherapy, radiotherapy, surgery. Our retrospective study aimed to analyze prognostic factors results in different age groups patients. Between 1998 2018, 569 patients ES were treated two referral centers. The divided into four (≤10 years; 11–18 19–25, >25). assessed for each group. For statistical analyses, we used Chi2 test, Kaplan–Meier estimator log-rank multivariate Cox...
Ewing sarcoma (ES) is a highly aggressive malignancy of bone and soft tissues characterized by the presence genetic fusion involving EWSR1 gene. More than one-third patients develop distant metastases, which are associated with unfavorable prognosis. Knowledge about disease's landscape may help foster progress in using targeted therapies treatment ES.The objective to assess mutational ES pretreatment samples, tumor samples after neoadjuvant chemotherapy, metastatic/recurrent tumors children...
Abstract Ewing sarcoma is the second most common type of primary bone cancer and predominantly affects children young people. Improved outcome prediction key to delivering risk-adjusted, appropriate effective care patients. Advances in Fourier Transform Infrared (FTIR) spectroscopy tissues enable it be a non-invasive method obtain information about biochemical content any biological sample. In this retrospective study, attenuated tissue reflection FTIR biopsy samples from paediatric patients...
Poniższy tekst ma na celu analizę zagadnień związanych z genezą i podstawami prawnymi polityki kulturalnej Unii Europejskiej. Autor omawia także kwestie związane udziałem Polski w polityce UE. Wykazuje, że uczestnictwo we wspólnotowych programy kulturalnych jest szansą rozwój działań kraju, a promocję kultury innych państwach europejskich.
In recent years, modifications of treatment protocols introduced in pediatric oncology have resulted a significant improvement outcomes. Unfortunately, the probability subsequent malignant neoplasm (SMN) this group patients is 3 to 6 times higher than general age-matched population. study, we sought evaluate options for with secondary bone tumors after prior anti-cancer therapy.Twenty-four (median age 12.9 years) were treated according oncological guidelines sarcoma during period 1991-2020....
Abstract Background Langerhans cell histiocytosis (LCH) affects 1–2 in 1,000,000 people. The disease is not associated with increased risk of treatment failure (especially among older children), but appropriate procedures implemented advance can eliminate complications which might appear and significantly worsen the patients’ quality life. Thus, we sought to evaluate clinical features, management, outcome children LCH treated Polish pediatric hematology-oncology centers. Materials methods...
Distal tibial primary bone tumors are rare, and options for limb salvage surgery limited challenging. Importantly, local control has shown to be crucial necessary cure, radical is one of the most important components therapy some sarcomas. We investigated feasibility functional oncological outcomes distal reconstruction using endoprosthesis in children with malignant tumors.Fourteen patients (median age 13.6 years) (4 Ewing sarcoma [ES], 10 osteosarcoma) tibiae were treated during 2013-2019....
Although there are several prognostic factors for patients with Ewing sarcoma (ES), but so far they have not been implemented in decision-making routine practice. The aim of our study was to build a model overall survival (OS) after potentially curative treatment locally advanced ES. We analyzed data on 256 consecutive nonmetastic ≤25 years age treated between 1998 and 2018 Mother Child Institute, Warsaw (n=192) Maria Sklodowska-Curie National Research Institute Oncology (n=64). Training set...