A5048412943- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Obstructive Sleep Apnea Research
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- EEG and Brain-Computer Interfaces
- Tracheal and airway disorders
- Neural dynamics and brain function
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Musculoskeletal pain and rehabilitation
- Temporomandibular Joint Disorders
- Botulinum Toxin and Related Neurological Disorders
- Airway Management and Intubation Techniques
- Pharmacological Effects and Assays
- Neural and Behavioral Psychology Studies
- Neurological disorders and treatments
- Pain Management and Treatment
- Pediatric health and respiratory diseases
- Functional Brain Connectivity Studies
- Cardiovascular and Diving-Related Complications
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Otitis Media and Relapsing Polychondritis
- Dysphagia Assessment and Management
Neuroscience Research Australia
2018-2025
UNSW Sydney
2020-2025
Western University
2023
University of Newcastle Australia
2023
The University of Sydney
2002-2011
Westmead Institute
2007
Westmead Hospital
2007
Key points A decreased respiratory arousal threshold is one of the main contributors to obstructive sleep apnoea (OSA) pathogenesis. Several recent studies have sought find a drug capable increasing without impairing pharyngeal muscle activity reduce OSA severity, with variable success. Here we show that zolpidem increases by ∼15%, an effect size which was insufficient systematically decrease severity as measured apnoea‐hypopnoea index. Unlike physiological findings showed paradoxical in...
Recent research has linked individual peak alpha frequency (PAF) to pain sensitivity, but whether PAF alterations can influence remains unclear. Our study investigated the effects of nicotine on sensitivity and changes are mediated by changes. In a randomised, double-blind, placebo-controlled experiment, 62 healthy adults (18–44 years) received either 4 mg gum (n=29) or placebo (n=33). Resting state EEG ratings during prolonged heat pressure models were collected before after intake. The...
Abstract Background and objective Atomoxetine combined with oxybutynin (Ato‐Oxy) has recently been shown to reduce obstructive sleep apnoea (OSA) severity by >60%. However, Ato‐Oxy also modestly reduced the respiratory arousal threshold, which may decrease quality/efficiency. We sought investigate additional effect of zolpidem on efficiency (primary outcome), OSA severity, other standard polysomnography (PSG) parameters, next‐day sleepiness alertness (secondary outcomes). Methods Twelve...
Abstract Background Biomarkers would greatly assist chronic pain management. The present study aimed to undertake analytical validation of a sensorimotor cortical biomarker signature for consisting two measures: peak alpha frequency (PAF) and corticomotor excitability (CME), using human model prolonged temporomandibular (masseter intramuscular injection nerve growth factor [NGF]). Methods 150 participants received an NGF the right masseter muscle on Days 0 2, inducing lasting up 4 weeks....
Transcranial magnetic stimulation (TMS) has been used to examine inhibitory and facilitatory circuits during experimental pain in chronic populations. However, current applications of TMS have restricted measurements motor evoked potentials (MEPs) from peripheral muscles. Here, was combined with electroencephalography (EEG) determine whether could induce alterations cortical inhibitory/facilitatory activity observed TMS-evoked (TEPs). In Experiment 1 (n=29), multiple sustained thermal...
Temporomandibular disorder (TMD) is a common condition that frequently transitions to chronic symptoms. Experimental pain models mimic the symptoms of clinical TMD may be useful in understanding mechanisms, and sex differences, present this disorder. Here we aimed comprehensively characterise nature time-course pain, functional impairment hyperalgesia induced by repeated intramuscular injection nerve growth factor (NGF) into masseter muscle, investigate differences NGF-induced experience.94...
Oral appliance (OA) therapy is the leading alternative to continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA). It well tolerated compared with CPAP. However, ≥50% of patients using OA have incomplete resolution their OSA. Combination CPAP and oral (CPAP + OA) a potential responders therapy. This study aimed determine extent which combination reduces therapeutic requirements gold-standard physiological methodology in those who an response alone. Sixteen [residual...
Temporomandibular disorder is a common musculoskeletal pain condition with development of chronic symptoms in 49% patients. Although number biological factors have shown an association temporomandibular cross-sectional and case control studies, there are currently no biomarkers that can predict the symptoms. The PREDICT study aims to undertake analytical validation novel peak alpha frequency (PAF) corticomotor excitability (CME) biomarker signature using human model transition sustained...
A recently developed, physiologically based continuum model of corticothalamic electrodynamics is used to derive the theoretical form electroencephalographic wave-number spectrum and its projection onto a one-dimensional recording array. The projected found consist plateau followed by regions power-law decrease with various exponents, which are dependent on both parameters temporal frequency. compared experimental results obtained in other studies, showing good agreement. provides framework...
High nasal resistance is associated with oral appliance treatment failure in obstructive sleep apnea (OSA). A novel a built-in airway has been shown to reduce pharyngeal pressure swings during and may be efficacious those high resistance. The role of posture mandibular advancement on OSA remains unclear. This study aimed determine (1) the effects (2) efficacy new device including patients resistance.A total 39 people (7 females, apnea-hypopnea index (AHI) (mean ± standard deviation) = 29 21...
This study evaluated upper airway muscle function, breathing, and comfort across different HFNC flows temperatures. There were no increases in genioglossus activity at higher despite greater negative epiglottic pressure swings. Increasing swings was associated with increasing discomfort the nonheated mode. ∼7 cmH 2 O increase positive pressure, which may be primary mechanism for stability rather than pharyngeal activity.
Abstract Repetitive transcranial magnetic stimulation (rTMS) holds promise as a non-invasive pain treatment. Given the link between individual peak alpha frequency (PAF) of resting-state electroencephalographic recordings and sensitivity, potential for rTMS to modulate PAF, we investigated these relationships through secondary analysis established rTMS-induced analgesia in an experimental model sustained muscle pain. In randomised, single-blind, sham-controlled experiment, 30 healthy adults...
Rationale: There are widespread histaminergic projections throughout the brain, including hypoglossal nuclei, that modulate pharyngeal muscle tone and respiratory control. Hence, stimulation pharmacologically may increase stabilize control (loop gain) to reduce obstructive sleep apnea (OSA) severity. Antimuscarinics also REM in rats. Thus, a combination of anti-muscarinic drugs be novel target for OSA pharmacotherapy. However, this has not been investigated. Accordingly, we aimed test...
Recent research has linked individual peak alpha frequency (PAF) to pain sensitivity, but whether PAF alterations can influence remains unclear. Our study investigated the effects of nicotine on sensitivity and changes are mediated by changes. In a randomised, double-blind, placebo-controlled experiment, 62 healthy adults (18–44 years) received either 4 mg gum (n=29) or placebo (n=33). Resting state EEG ratings during prolonged heat pressure models were collected before after intake....
Transcranial magnetic stimulation (TMS) has been used to examine inhibitory and facilitatory circuits during experimental pain in chronic populations. However, current applications of TMS have restricted measurements motor evoked potentials (MEPs) from peripheral muscles. Here, was combined with electroencephalography (EEG) determine whether could induce alterations cortical inhibitory/facilitatory activity observed TMS-evoked (TEPs). In Experiment 1 (n=29), multiple sustained thermal...
Abstract Recent research has linked individual peak alpha frequency (PAF) to pain sensitivity, but whether PAF alterations can influence remains unclear. Our study investigated the effects of nicotine on sensitivity and changes are mediated by changes. In a randomised, double-blind, placebo-controlled experiment, 62 healthy adults (18–44 years) received either 4 mg gum (n=29) or placebo (n=33). Resting state EEG ratings during prolonged heat pressure models were collected before after...