A5052777152- Acute Lymphoblastic Leukemia research
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Prenatal Screening and Diagnostics
- Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Antioxidant Activity and Oxidative Stress
- Immunodeficiency and Autoimmune Disorders
- Medical Imaging and Pathology Studies
- Bone Metabolism and Diseases
- Renal Transplantation Outcomes and Treatments
- Polyomavirus and related diseases
- Dermatological and Skeletal Disorders
- Genetic factors in colorectal cancer
- Histiocytic Disorders and Treatments
- Bone health and treatments
- Intraperitoneal and Appendiceal Malignancies
Medical University of Lublin
2013-2021
Uniwersytecki Szpital Dziecięcy
2019
Kinderkrebs-Zentrum Hamburg
2004
Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed results of AML treatment Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering treated with following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, 74), 98 (1998–2004, 151), AML-BFM 2004...
Burkitt's lymphoma accounts for approximately 25% of lymphomas diagnosed in children developmental age. The tumor is localized mainly the intestine (usually ileocecal region), mesenteric lymph nodes and extraperitoneal space. clinical symptoms are non-specific include: abdominal pain, vomiting, gastrointestinal bleeding, acute abdomen suggesting appendicitis or intestinal intussusception. On ultrasound examination, may manifest itself various ways, depending on origin lesion.The aim this...
Abstract Background The significance of very early chimerism assessment before day + 28, which is considered the moment engraftment, still unclear. In this retrospective study, we evaluated clinical impact on outcome after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukaemia (ALL). Methods study group included 38 boys and 18 girls. Very was days 7, 14, 21 28 transplant. Short tandem repeat polymerase chain reaction (STR PCR) used to...
11q23/MLL rearrangements are frequently detected in pediatric acute myeloid leukemia. The analysis of their clinical significance is difficult due to the multitude translocation fusion partners and low frequency. presence t(10;11)(p12;q23) was previously identified AML. It considered as second most common 11q23/MLL-rearranged (present KMT2A) AML, after t(9;11)(p22;q23). above an unfavorable prognostic factor. Since June 2015 Polish Pediatric Leukemia/Lymphoma Study Group has applied...
Background: Children with Down syndrome (DS) have increased risk of myeloid leukemia, but specific treatment protocols ensure excellent outcome. The aim the study was retrospective analysis results and genetic characteristics leukemia (ML-DS) in Poland from 2005 to 2019. Methods: All 54 patients ML-DS registered Polish Pediatric Leukemia Lymphoma Study Group analyzed period were enrolled study. There 34 children treated AML-BFM 2004 Interim protocol (group I) 20 2006 II). In first there...
Background: The aim of the study was to analyze treatment outcome and genetic characteristics acute promyelocytic leukemia (APL) in children Poland from 2005 2018. Methods: All 41 patients diagnosed with APL during analysis period were eligible for study. In I (2005-2015), 33 treated chemotherapy all-trans retinoic acid (ATRA), II (2015-2018), 3 (high risk) received induction ATRA arsenic trioxide (ATO), 5 (standard ATO without chemotherapy. Results: Probability 5-years overall survival...
Anaemia is a common manifestation in paediatric patients.The most cause of anaemia iron deficiency.In differential diagnosis not only the diseases resulting haemoglobin decrease should be considered, but also those less common.In an outpatient care physician's practice, interview, physical examination and routine periodic preventative examinations play very important role.They make it possible to detect chronic diseases, including congenital metabolic diseases.These include osteopetrosis,...
Simian Virus 40 (SV40), a potent oncogenic virus, has been prior associated with some human cancer, also lymphomas. Its potential is based on the large T-antigen (TAG). Very different findings as well lack of control groups in most reports make it difficult to assess SV40-lymphoma association.
Abstract Background: The significance of very early chimerism assessment before day +28, which is considered the moment engraftment, still unclear. In this retrospective study, we evaluated clinical impact on outcome after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukaemia (ALL). Methods: study group included 38 boys and 18 girls. Very was days +7, +14, +21 +28 transplant. Short tandem repeat polymerase chain reaction (STR PCR) used...
Abstract Background: The significance of very early chimerism assessment before day +28, which is considered the moment engraftment, still unclear. In this retrospective study, we evaluated clinical impact on outcome after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukaemia (ALL). Methods: study group included 38 boys and 18 girls. Very was days +7, +14, +21 +28 transplant. Short tandem repeat polymerase chain reaction (STR PCR) used...
Abstract In this retrospective study we evaluated the clinical impact of very early chimerism after allogeneic haematopoietic stem cell transplantation (allo-HSCT) in children with acute lymphoblastic leukaemia (ALL). The group included 38 boys and 18 girls. Very was on days +7, +14, +21 +28 transplant. Quantitative fluorescence polymerase chain reaction used to evaluate chimerism. Overall survival (OS) event-free (EFS) were 84% 80% respectively. OS 24 patients complete donor day +14 83% it...