A5061924630- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Bone health and treatments
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Multiple and Secondary Primary Cancers
- Immunotherapy and Immune Responses
- Testicular diseases and treatments
- Family Support in Illness
- Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Bone health and osteoporosis research
- Reproductive Biology and Fertility
- Growth Hormone and Insulin-like Growth Factors
- Cancer Risks and Factors
- Hematological disorders and diagnostics
- Blood disorders and treatments
- Antifungal resistance and susceptibility
- Chronic Myeloid Leukemia Treatments
- Cancer-related cognitive impairment studies
- Hemoglobinopathies and Related Disorders
Medical University of Białystok
2016-2025
University Clinical Hospital In Bialystok
2008-2022
Szpital Kliniczny Dzieciątka Jezus
1999-2002
Summary The occurrence of late sequelae after myeloablative conditioning regimens for stem‐cell transplantation ( SCT ) has prompted the introduction reduced‐intensity chemotherapy RIC in an attempt to reduce toxicity and spare fertility. We retrospectively evaluated gonadal function survivors childhood by comparing patients conditioned with a regimen containing busulfan cyclophosphamide (BuCy, N = 51, 28 boys) fludarabine melphalan (FluMel, 40, 19 boys). Spontaneous puberty occurred 56%...
PURPOSE Soon after the Russian invasion of Ukraine in February 2022, an initiative was organized to evacuate Ukrainian children with cancer, most initially Poland. This study assessed impact this rapid increase clinical need on Polish system pediatric cancer care. METHODS multicenter longitudinal approach performed among all 19 Pediatric Oncology Centers (PPOCs). We compared PPOC capacity before that during first 11 weeks invasion, using three ratios: patients physicians (PtP), nurses (PtN),...
ABSTRACT Background The prognostic role of systemic inflammation markers in pediatric soft‐tissue sarcomas (STS) remains unclear. Procedure This multicenter study investigated the significance neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte (PLR), lymphocyte‐to‐monocyte (LMR), immune‐inflammation index (SII), inflammatory response (SIRI), C‐reactive protein (CRP), and lactate dehydrogenase (LDH) 213 patients diagnosed with STS years 2002–2023. Patients were categorized into...
Background: Acinetobacter, significantly A.baumannii, are becoming a great threat to hospitalized patients due increasing antibiotic resistance. The aim of this study was describe the epidemiology, clinical characteristic, antimicrobial susceptibility pattern and outcome Acinetobacter infections in pediatric cancer HSCT recipients Poland. Methods: total 125 episodes species were reported pa-tients < 18 years treated Polish hematology oncology centers over pe-riod from 2012 2023....
Abstract Background Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently constitutes the leading and overwhelming health issue worldwide. In comparison with adults, children present milder symptoms, most having an asymptomatic course. We hypothesized that COVID-19 infection has a negative impact on continuation of chemotherapy increases nonrelapse mortality. Material methods This study was performed to assess course SARS-CoV-2...
Transfusions of packed red blood cells (PRBCs), given due to an oncological disease and its acute complications, are indispensable part anticancer therapy. However, they can lead post-transfusion iron overload. The study aim was evaluate the role ferritin as a nonspecific marker leukemic growth transfusion-related We performed longitudinal PRBC transfusions changes in concentrations during treatment 135 patients with childhood lymphoblastic myeloblastic leukemia (ALL AML, median age 5.62...
Background/aim: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment childhood cancers is still evolving. aim this nationwide retrospective study was to assess safety and effectiveness ICIs used a group 42 patients, with median age 13.6 years, various types advanced malignancies treated pediatric oncology centers Poland between 2015 2023. Results: indications for anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); other (14)....
We evaluated ovarian function by measuring the levels of anti-Müllerian hormone (AMH), estradiol, and gonadotropins in 83 young women treated for cancer during childhood adolescence, classified according to post-treatment gonadal toxicity versus 38 healthy females. Results. The mean AMH values were lower entire cohort independently risk group as compared control, whereas FSH was elevated only high group. lowest noted patients after bone marrow transplantation (BMT) those Hodgkin lymphoma...
In the last 40 years, considerable progress was made in treatment of childhood cancer. Nearly 80% children achieve long-term clinical remission or are permanently cured. This improvement is however not without sacrifice. first Polish study analyzing general health status and epidemiology organ late effects cohort adolescent cancer survivors monitored by doctors registered on-line national database for (N = 1761). tool collects information on previous therapy current (medical history,...
Clostridium difficile infection (CDI) is one of the most common causes nosocomial infectious diarrhea in children during anticancer therapy or undergoing hematopoietic stem cell transplantation (HSCT) Europe. Immunosuppression these patients a risk factor for CDI. Malignant diseases, age, acute graft-versus-host disease (aGVHD), HLA mismatch, use total body irradiation may play an important role CDI course. The aim this study was to evaluate incidence, course, and outcome treated malignancy...
Owing to advances in treatment modalities and supportive care, overall survival rates have reached up 90% among children with acute lymphoblastic leukemia (ALL). However, due the underlying illness therapy, they are at a greater risk of developing lifestyle diseases. Hence, special attention is paid early detection components metabolic syndrome (MetS). This study aimed investigating association plasma levels nine diabetes markers being overweight MetS ALL survivors. The included 56 subjects...
Abstract Introduction Nephrotoxicity is a potential adverse effect of anticancer treatment in childhood. Cytostatics, abdominal radiotherapy, total body irradiation (TBI) and some agents used supportive care may induce acute kidney injury (AKI) or lead to chronic disease (CKD). The aim this study was test the hypothesis whether urinary molecule-1 (KIM-1) neutrophil gelatinase-associated lipocalin (NGAL) are increased lymphoblastic leukemia (ALL) survivors. Method cohort consisted 86 patients...
Abstract The aim of the study was to retrospectively compare effectiveness ALL IC-BFM 2002 and 2009 protocols distribution risk groups by two after minimal residual disease (MRD) measurement as well its impact on survival. We reviewed medical records 3248 patients aged 1–18 years with newly diagnosed who were treated in 14 hemato-oncological centers between 2018 Poland. overall survival (OS) 1872 children IC protocol 84% 3 years, whereas OS 1376 87% ( P < 0.001). corresponding event-free...
Childhood acute lymphoblastic leukemia (ALL) survivors are at higher risk of developing many late effects later in life. They experience multiple health problems that have significant public implications, such as frailty, premature onset lifestyle diseases, and second tumors. There is some evidence chronic inflammation causes accelerated aging childhood cancer survivors; however, the available data very limited. The aim study was to evaluate broad panel cytokines among asymptomatic ALL after...
Anticancer treatment can disturb gonadal function and deplete the primordial follicle pool, leading to premature menopause. We made a prospective analysis of serum hormone levels in young female cancer survivors who had been treated during childhood adolescence. Serum anti-Müllerian (AMH) as marker ovarian reserve, FSH, LH, estradiol were measured 33 women previously (6-11 years earlier) for Hodgkin Lymphoma, solid tumours, after bone marrow transplantation, 34 healthy controls. The group...
Background: From 1983, standardized therapeutic protocols for pediatric acute myeloid leukemia (AML) based on the BFM group experience were introduced in Poland. We retrospectively analyzed results of AML treatment Poland from 1983 to 2019 (excluding promyelocytic, therapy-related, biphenotypic, and Down syndrome AML). Methods: The study included 899 children suffering treated with following: AML-PPPLBC 83 (1983–1993, n = 187), AML-PPGLBC 94 (1994–1997, 74), 98 (1998–2004, 151), AML-BFM 2004...