Monika Drogosiewicz
A5004805806- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Hedgehog Signaling Pathway Studies
- Childhood Cancer Survivors' Quality of Life
- Ocular Oncology and Treatments
- DNA Repair Mechanisms
- Brain Metastases and Treatment
- Vascular Malformations Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Cerebrospinal fluid and hydrocephalus
- Soft tissue tumor case studies
- Microtubule and mitosis dynamics
- Radiation Therapy and Dosimetry
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- Infrared Thermography in Medicine
- PARP inhibition in cancer therapy
- Peptidase Inhibition and Analysis
- Chromatin Remodeling and Cancer
- Advanced Glycation End Products research
- CAR-T cell therapy research
Children's Memorial Health Institute
2009-2024
Instytut Matki i Dziecka
2007-2019
Shanghai Jiao Tong University
2012
Diffuse intrinsic pontine glioma (DIPG) is a rare clinically, neuro-radiologically, and molecularly defined malignancy of the brainstem with median overall survival approximately 11 months. Our aim to evaluate current tendency for its treatment in Europe order develop (inter)national consensus guidelines.Healthcare professionals specialized DIPG were asked fill an online survey questions regarding usual strategies at diagnosis disease progression their countries and/or centers,...
Recent studies revealed the biological heterogeneity of medulloblastoma, with existence at least four groups which are associated several clinical and morphological features. We investigated for further correlations between molecular types, location tumours, their contrast enhancement pattern survival patients. Altogether 76 tumours were analyzed subtypes identified by immunohistochemistry using representative antibodies, detection chromosome 6 monosomy CTNNB1 mutation. The site tumour was...
Medulloblastoma (MB) is the most common malignant tumor of central nervous system in childhood. FTIR spectroscopy provides a holistic view chemical composition biological samples, including detection molecules such as nucleic acids, proteins, and lipids. This study evaluated applicability potential diagnostic tool for MB.FTIR spectra MB samples from 40 children (boys/girls: 31/9; age: median 7.8 years, range 1.5-21.5 years) treated Oncology Department Children's Memorial Health Institute...
Background/aim: The role of immune checkpoint inhibitors (ICIs; anti-PD1) in the treatment childhood cancers is still evolving. aim this nationwide retrospective study was to assess safety and effectiveness ICIs used a group 42 patients, with median age 13.6 years, various types advanced malignancies treated pediatric oncology centers Poland between 2015 2023. Results: indications for anti-PD1 were as follows: Hodgkin lymphoma (11); malignant skin melanoma (9); neuroblastoma (8); other (14)....
Abstract Purpose Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor. Radiation therapy (RT) the standard treatment, with reirradiation considered in case of progression. However, prognostic factors for are not well understood. This study aims to investigate outcomes DIPG patients undergoing and identify clinical radiomic factors. Methods We conducted retrospective analysis who underwent at our institution between January 2016 December 2023. Using PyRadiomics, we...
Background/Aim: Nivolumab is an immune checkpoint inhibitor with high antitumor activity in selected neoplasms. The aim of the study was to evaluate efficacy and safety nivolumab pediatric patients various types highly malignant advanced tumors. Patients Methods: Ten a median age 15.1 years were included study. indications for treatment were: skin melanoma (n=5), brain tumor (n=2), (n=1), Hodgkin lymphoma (n=1) soft tissue sarcoma (n=1). Results: Complete disease remission observed 4...
Medulloblastoma, the most common malignant pediatric brain tumor, is a heterogeneous disease, with existence of at least four molecular types: Wingless (WNT), Sonic Hedgehog (SHH), Group 3 and 4 tumors. The latter two groups, which can be identified by an application multi-gene expression or methylation profiling, show sometimes ambiguous categorization are still classified for diagnostic reason as non-SHH/non-WNT medulloblastomas in updated WHO 2016 classification. In order to better...
ALK gene rearrangements were identified in a variety of cancers, including neuroblastoma, where the presence expression is associated with adverse prognosis. mutations have recently been found pediatric brain tumor medulloblastoma, and microarray data indicate that highly expressed subset these tumors. Therefore, we investigated whether correlates transcriptional profiles clinical features medulloblastoma. Tumors from 116 medulloblastoma patients studied at diagnosis for detection RNA level...
The defects in DNA repair genes are potentially linked to development and response therapy medulloblastoma. Therefore the purpose of this study was establish spectrum frequency germline variants selected their impact on chemotherapy medulloblastoma patients.The following were investigated 102 paediatric patients: MSH2 RAD50 using targeted gene panel sequencing NBN (p.I171V p.K219fs*19) by Sanger sequencing. In three patients with presence rare life-threatening adverse events (AE) no detected...
Background: Papillary pineocytoma is an extremely rare tumor usually with a poor outcome. Case report: We report case of 10-year-old-girl pineal gland and obstructuve hydrocephalus diangnosed using MRI. The child was successful treated by insertion ventriculoperitoneal shunt consecutive resection supracerebellar-infratentorial approach. Histopathological examination showed papillary structure the pineocytoma. As such, tumors are considered to be aggressive subjected radio- chemotherapy....
Abstract BACKGROUND Diffuse Intrinsic Pontine Glioma (DIPG) is a lethal pediatric brain tumor. Radiation therapy (RT) the standard treatment, with reirradiation considered at progression. However, prognostic factors for remain unclear. This study aims to investigate outcomes of patients DIPG undergoing and identify radiomic factors. METHODS We analyzed histopathologically proven who underwent our institution. delineated pre-reirradiation tumors using 3D Slicer software extracted features...
Abstract BACKGROUND Pediatric ependymomas are aggressive central nervous system malignancies arising from the ependymal linings of ventricles and spinal canal. Despite better understanding tumor biology remain therapeutic challenge in pediatric neurooncology. The role chemotherapy remains controversial. Herein, we describe outcomes patients treated at largest center Poland who underwent surgery, pre-irradiation irradiation regardless extent surgical resection. METHODS This retrospective...
Abstract INTRODUCTION Infants constitute approximately 5% of all pediatric LGG. This group is identified as having aggressive course and worse prognosis compared to older children. No specific therapeutic guidelines are yet available for this age group. AIM: Retrospective analysis infants diagnosed treated METHODOLOGY: 25 patients between 2001-2023 were analyzed for: sex, age, tumor location, pathology, treatment outcome. NF1 excluded. RESULTS There 13 boys 12 girls, aged 3 months-11 months,...
Medulloblastoma (MB) accounts for approximately 20% of pediatric central nervous system neoplasms.Current standard management includes safe maximal surgical resection followed by craniospinal irradiation (CSI) with chemotherapeutic radiosensitization adjuvant chemotherapy.The overall and event free survival rates depend upon many prognostic factors.PURPOSE: To investigate treatment outcome newly diagnosed MB patients treated at the Children's Cancer Hospital Egypt 57357 (CCHE) to determine...
BACKGROUND: Malignant pediatric brain tumors constitute a heterogeneic group of central nervous system tumors, and general markers diagnosis prognosis are not available. Recently, panel CD (CD15, CD24, CD29) was used to define increasing neural differentiation embryonic stem cells. Although these have been associated with worse due presence tumor propagating cells, alterations in adhesion migration various cancer types, no studies multiple performed. METHODS: We collected including...