A5068554625- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Retinal Development and Disorders
- Adipose Tissue and Metabolism
- Glaucoma and retinal disorders
- Pain Mechanisms and Treatments
- Nerve Injury and Rehabilitation
- S100 Proteins and Annexins
- Diet and metabolism studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disorders and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Tuberous Sclerosis Complex Research
- Spinal Cord Injury Research
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Axon Guidance and Neuronal Signaling
- Mitochondrial Function and Pathology
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neural Engineering
- Intracranial Aneurysms: Treatment and Complications
- Protease and Inhibitor Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Botulinum Toxin and Related Neurological Disorders
Medical University of Silesia
2015-2024
Katowice School of Technology
2022-2024
University of Economics in Katowice
2016-2018
Children's Memorial Health Institute
2006
Czech Academy of Sciences, Institute of Physiology
2000
Katowice School of Economics
1998
Górnośląskie Centrum Medyczne
1992-1994
In the central nervous system, tuberous sclerosis complex (TSC) is characterized by a range of lesions including cortical tubers, white matter heterotopias, subependymal nodules, and giant cell astrocytomas (SEGAs). Recent studies have implicated an important role for TSC genes TSC1 TSC2, in signaling pathway involving mammalian target rapamycin (mTOR) kinase. We performed immunohistochemical genetic analyses on SEGAs from 7 patients, 4 with mutations TSC1, 3 TSC2. SEGA cells show high...
Acute cerebral ischemia triggers local and systemic immune response. The aims of this project was to assess the blood serum concentration markers inflammation brain barrier damage on first day ischemic stroke, mutual correlations between these marker levels. Patients with first-in-life stroke were analysed according to: plasma following stroke: interleukin 2 (IL-2) interleuki 6 (IL-6), S100B, tumor necrosis factor-α (TNF-α), progranulin (GRN), neuron specific enolase (NSE), urokinase-type...
BACKGROUND:According to recent studies, brain-derived neurotrophic factor (BDNF) probably plays a role in development of cerebral ischemia and can be significant for the prognosis improved mobility after stroke. The aim this prospective study was evaluate blood concentration BDNF during 1st day first-ever ischemic stroke find potential association between neurological status acute period, as well functional sub-acute phase MATERIAL AND METHODS:The involved 87 patients aged 39–99 years (42...
Abstract Nutritional imbalance underlies many disease processes but can be very beneficial in certain cases; for instance, the antiepileptic action of a high fat and low carbohydrate ketogenic diet. Besides this therapeutic feature it is not clear how abundant supply may affect homeostasis, leading to side effects. A diet used as anti-seizure therapy i.a. tuberous sclerosis patients, its impact on concomitant tumor growth known. To examine we have evaluated renal lesions Eker rats ( Tsc2+/−...
Abstract Injury of peripheral nerve is associated with the development post‐traumatic neuroma at end proximal stump, often being origin neuropathic pain. This type pain therapy‐resistant and therefore extremely nagging for patients. We examined influence microcrystallic chitosan gel applied to stump totally transected sciatic on formation in rats. In 14 rats, right was distal removed avoid spontaneous rejoining. (experimental) group ( n = 7), covered a thin layer gel. control animals cut...
Glaucoma is a chronic disease that causes structural and functional damage to retinal ganglion cells (RGC). The currently employed therapeutic options are not sufficient prevent vision loss in patients with glaucoma; therefore, there need develop novel therapies, which requires the creation of functional, repeatable easy-to-utilize animal models for use pre-clinical studies. available ensure only low moderate optic nerves, high variation outcomes poor repeatability. We have developed an...
Methamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in toxicity this drug. Cytokines among key mediators between systemic inflammatory status tissue responses. One these, interleukin 1 (IL-1), has hypothesized be functions also appears play pivotal role molecules. In present study, we demonstrate that exposure mice METH markedly increased...
Cardiac rhabdomyoma (CR) is the most common heart tumor in children and usually associated with tuberous sclerosis complex (TSC). Tuberous a genetic disorder caused by mutation either of 2 genes (TSC1 or TSC2) characterized formation hamartomas multiple organs. The TSC proteins, hamartin tuberin, antagonize mammalian target rapamycin (mTOR) signaling pathway, thus regulating cell growth proliferation. Recently, some trials treating mTOR inhibitor have been published; however, impact such...
Generator of spatial magnetic field is one most recent achievements among the magnetostimulators. This apparatus allows to obtain rotating field. new method may be more effective than other widely used techniques magnetostimulation and magnetotherapy. We investigated influence alternating, on regeneration crushed rat sciatic nerves. Functional morphological evaluations were used. After crush injury right nerve, Wistar C rats (n = 80) randomly divided into four groups (control three...
Understanding mechanisms of spinal cord injury and repair requires a reliable experimental model. We have developed new device that produces partial damage white matter by means precisely adjusted stream air applied under high pressure. This procedure is less invasive than standard contusion or compression models does not require surgical removal vertebral bones. investigated the effects made with our in 29 adult rats, applying different parameters. The rats were divided into three groups...
Acute cerebral ischemia triggers local and systemic immune response. The aims of this project was to assess the blood serum concentration markers inflammation brain barrier damage on first day ischemic stroke, mutual correlations between these marker levels. Methods Our prospective study included 138 patients with first-in-life who were analyzed according to: plasma following stroke: Il-2 IL-6, S100B, TNF alfa, GRN, NSE, uPA, VEGF, BDNF, CRP, leucocyte thrombocyte counts; their neurological...
Abstract Physical activity impacts brain functions, but the direct mechanisms of this effect are not fully recognized or understood. Among multidimensional changes induced by physical activity, fatty acids (FA) appear to play an important role; however, knowledge in area is particularly scarce. Here we performed global metabolomics profiling hippocampus and frontal cortex (FC) a model voluntary running mice. Examined structures responded differentially activity. Specifically, markers...
Introduction ELAVL1/HuR is a keystone regulator of gene expression at the posttranscriptional level, including stress response and homeostasis maintenance. The aim this study was to evaluate impact hur silencing on age-related degeneration retinal ganglion cells (RGC), which potentially describes efficiency endogenous neuroprotection mechanisms, as well assess exogenous capacity -silenced RGC in rat glaucoma model. Methods consisted vitro vivo approaches. In , we used B-35 investigate,...
In the subarachnoid hemorrhage (SAH) blood mixes with cerebrospinal fluid, what starts immunoinflammatory processes - increased synthesis of proinflammatory cytokines, and formation reactive oxygen species (ROS), resulting in pre-activation different populations peripheral leukocytes. Migration leukocytes to brain parenchyma through broken barrier may produce extra tissue injury besides that from SAH. We examined adult rats effect interleukin-1β (IL-1β) neutralization on secretion cytokines...
Subarachnoid hemorrhage (SAH) develops when extravasated arterial blood enters subarachnoid space and mixes with cerebrospinal fluid. As a result, many pathologies develop, including vasospasm that leads to the ischemia hypoxia. Immuno-inflammatory response is considered as cause of numerous complications following SAH. In study, we examined role one major cytokines, interleukin 1-beta (IL-1beta), on vascular after experimental SAH in adult rats. was produced by injection 150 uL autologous...